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Update on COVID-19 Infections and the Promising Role of Mesenchymal Stem Cell Therapies in their Management

Al-Anazi KA1*, Al-Anazi WK2 and Al-Jasser AM3<

Affiliation(s): 1Department of Hematology and Hematopoietic Stem Cell Transplantation, Oncology Center, King Fahad Specialist Hospital, King Fahad Specialist Hospital, P.O. Box: 15215, Dammam 31444, Saudi Arabia

2Section of Cytogenetics, Department of Pathology, King Fahad Specialist Hospital, P.O. Box: 15215, Dammam 31444, Saudi Arabia

3Department of Research and Studies, General Directorate of Health Affairs in Riyadh Region, Ministry of Health, Riyadh 12822, Saudi Arabia

Subject Category: Stem Cell Therapy

The pandemic of COVID-19 has adversely affected almost every aspect of our lives but the world health and economic sectors suffer most of the repercussions of this disease. The search for a cure for this rapidly spreading virus which is causing massive life losses around the globe requires clear understanding of the immunopathogenesis of this virus as well as the mechanisms of actions of the various therapeutic modalities that are employed in the treatment of this life-threatening viral infection. Mesenchymal stem cells have antimicrobials effects in addition to their anti-inflammatory and immunomodulatory properties. They have been utilized in the treatment of various infections and their complications both in animal models and in human clinical trials. Mesenchymal stem cells derived from certain sources and their secretory products are particularly effective in the treatment of pneumonia, sepsis, acute lung injury, and acute respiratory distress syndrome which are common complications of COVID-19 infections. The review will discuss the various aspects of COVID-19 and it will highlight the promising role of mesenchymal stem cells in treating the complications of COVID-19 infections.

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