Articles

Save the radial: go distally

Published on: 7th April, 2022

Coronary artery disease is the leading cause of death worldwide.Percutaneous coronary intervention (PCI) is one of the most widely performed medical procedures used to save lives, currently over 3 million annually worldwide.The femoral artery has been the preferred vascular access site. However, radial access is gaining extensive popularity due to the benefits of earlier ambulation, fewer access site complications, and decreased rates of bleeding. Improvements in technology and understanding of the anatomic features of the vascular system have led to new insights into coronary angiography procedures.Distal radial access, which was first used in 2017, shows a higher success rate and fewer complications than previous sites; therefore, it might be the future for cardiovascular intervention.For this purpose, we conducted this prospective study at Beirut Cardiac Institute (BCI) comparing the two arms: radial vs. distal radial artery techniques through the anatomical snuffbox, in terms of patient’s length of stay, complication rate, and success rate of each procedure.
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Assessment of knowledge of acute kidney injury among non-nephrology healthcare workers in North-Kivu Province, Democratic Republic of the Congo

Published on: 6th April, 2022

OCLC Number/Unique Identifier: 9470693131

Background: Assessment of knowledge of acute kidney injury (AKI) among healthcare workers (HCWs) is necessary to identify areas of deficiency and key topics to focus on while organizing educational programs to improve AKI care. The objective of this study was to assess AKI knowledge and practice among health care providers in North Kivu province, the eastern Democratic Republic of the Congo. Material and methods: This was a cross-sectional study conducted in six public hospitals in North Kivu province using a self-administered questionnaire. Results: A total of 158 HCWs completed the survey, among them 66 (41.78%) were physicians. The mean age of respondents was 36.07 ± 10.16 years and the male gender was 56.33%. Only 12 (7.59%) of the respondents had a good knowledge of the definition and classification of AKI. The respondents’ mean scores were 6.76 out of a total of 18 about risk factors for AKI and 6.29 out of a total of 11 with regard to nephrotoxic drugs. Regarding practices, 28.48% of the respondents assess the risk of AKI in their patients in their daily practices; 31.65% report AKI in the patients’ medical history, and 33.54% call on a nephrologist specialist to get specialized advice. Conclusion: This study found considerable gaps in knowledge and practice regarding AKI among most of HCWs in North Kivu province. 
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Stage and symptoms of bipolar disorders

Published on: 6th April, 2022

Bipolar disorder (formerly called manic-depressive illness or manic depression) is a mental disorder that causes unusual shifts in mood, energy, activity levels, concentration, and the ability to carry out day-to-day tasks. During mood swings, there may be features of psychosis (delusions and hallucinations) that are mood-congruent. Although psychotic symptoms are seen only in a minority of patients, they explain the early terminology of manic–depressive psychosis. Stage 1a is defined as mild or non-specific symptoms of mood disorder and intervened as formal mental health literacy; family psychoeducation; substance abuse reduction; cognitive behavioral therapy. Euphoric means the experience of pleasure or excitement and intense feelings of well-being and happiness. Certain natural rewards and social activities, such as aerobic exercise, laughter, listening to or making music, and dancing, can induce a state of euphoria. Racing thoughts are consistent, persistent, often intrusive thoughts that come in rapid succession. There is a direct link between depression and anxiety and racing thoughts. Whereas jumping from topic to topic as in the flight of ideas can be observed by others, ascertainment of racing thoughts requires asking the child whether his or her thoughts seem to be going too fast.
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Nematicides in Egypt

Published on: 5th April, 2022

Plant-parasitic nematodes (PPNs) are famous aggressive pests that attack several crops worldwide. A lot of farmers are suffering from nematode diseases which cause critical crop losses. At the same time, the most of available solutions for this problem are depending on synthetic nematicides. These chemical nematicides not only cause environmental and health problems but also may cause resistance in nematodes. Despite the occurrence of resistance in nematodes under field conditions still less clear. Therefore, this note is about the registered nematicides in Egypt which may help those who are interested in nematicides. Also, the chemical group and mode of action of nematicides were mentioned according to the insecticide resistance action committee (IRAC) [1] and fungicide resistance action committee (FRAC).
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Menstrual cycle effects on sleep

Published on: 5th April, 2022

OCLC Number/Unique Identifier: 9470691728

Sleep and menstrual cycle both are normal physiological processes in women’s life but they are regulated by different centers. Sleep is a daily rhythm whereas the menstrual cycle lasts for 28 days. During this period the estrogen peaks twice. We have shown earlier that there is an inverse relationship between estrogen and the hormone melatonin which aids sleep. Because of this menstruating women will have sleep disorders.
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Ceftriaxone in pediatrics: Indication, adverse drug reaction, contraindication and drug interaction

Published on: 5th April, 2022

OCLC Number/Unique Identifier: 9470678055

Ceftriaxone is having many uses and useful “third-generation” cephalosporin that necessitates being given every day. Ceftriaxone acts as binds to one or many of the penicillin-binding proteins which inhibit the final transpeptidoglycan step of peptidoglycan synthesis in the bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.Ceftriaxone-associated biliary adverse events in children less than eighteen years cause biliary pseudolithiasis and scarcely nephrolithiasis often happen in children less than eighteen years after receiving overdoses of ceftriaxone. Ceftriaxone perhaps binds with calcium and figure insoluble chelation leading to biliary pseudolithiasis. Cholelithiasis, increased biliary thickness, and pseudolithiasis rarely happen in a period of being a child, but there are two modes of distribu¬tion described by two peaks, the first being at an early stage of development and the second is a period of life when a child develops into an adult. Hyperbilirubinemia is significantly contraindicated for neonates administrated ceftriaxone, particularly premature neonates, because of the displacement of bilirubin from albumin-binding sites and increase in blood concentrations of free bilirubin. A child than one month old and a child less than twelve-month old in special are at great risk of poor results because of bilirubin encephalopathy. Coincident administrations of ceftriaxone with aminoglycosides such as gentamycin and loop diuretics (furosemide) perhaps increase the risk of nephrotoxicity (rapid degeneration in the kidney function to the toxic outcome of double or triple medications). Coincident administrations of ceftriaxone with anticoagulant medications such as warfarin are associated with bleeding due to increased prothrombin times, which is reversible with vitamin K.
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Age-related changes in cell yield and viability of feline Adipose Tissue-Derived Mesenchymal Stem (fAD-MSCs)

Published on: 1st April, 2022

In the present study, omental adipose tissue was collected from, the animals that underwent ovariectomy and ovariohysterectomy, surgical procedures, at the age of seven months to 11/2 years of age groups. The sample was digested with 0.1% (W/V) collagenase type I and transferred to a beaker with a magnetic stirrer and kept in a stirrer with 600 rpm at 37 °C for 30 minutes. The viability of the cell was evaluated by the trypan blue exclusion method using a hemocytometer. Trypan blue had a high affinity to nuclear DNA, which traverse the member in a dead cell and dye it blue. In the present study, the cell yield of fAD-MSCs was 8.15 ± 0.68, 6.55 ± 0.26, 4.85 ± 0.42, 3.90 ± 0.34, and 3.51 ± 0.43 in different age groups viz., 7,8,9 month 1 and 1½ year respectively. In younger age groups, cell yield and viability percentage were more than in animals of higher age groups. In the younger age group, stem cells proliferation status is considered potent for therapeutic application.
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Magnitude of aphid infestation, root rot and rust disease of lentil

Published on: 31st March, 2022

OCLC Number/Unique Identifier: 9470200773

Lentil is the major cultivated pulse crop of Bangladesh. Even if there are available high-yielding modern varieties of this crop but because of the higher yield gap, its demand is largely met by import. Thus, to evaluate the pest-related factors of low yield seven modern lentil varieties viz. Binamasur-5, Binamasur-8, Binamasur-9, Binamasur-10, BARI Masur-5, BARI Masur-6, and BARI Masur-8 were assessed to enquire the extent of aphid infestation, foot rot and rust disease incidence, and severity on seed yield. The experiment was laid out in a Randomized complete block design during Rabi season at BINA Sub-station, Magura. Data on insects and disease were recorded at definite SMW (standard meteorological week) and DAS (days after sowing). Outcomes divulged that maximum aphid infestation (number of aphids/plant) was noted between 7th to 9th SMW; where BARI Masur-6 had significantly lowest infestation level on 7th and 8th SMW. Summative foot rot disease incidence (%) was most in Binamasur-8 and Binamasur-9, but least in BARI Masur-6 and Binamasur-5. For rust, the highest incidence (%) was recorded with Binamasur-8 and Binamasur-5; contrary the lowest was seen with BARI Masur-6 and BARI Masur-8. Severity index (DSI) of foot and root rot was abundant by Binamasur-8 (72.89%) and Binamasur-9 (71.56%); conversely, Binamasur-10 (52.11%) and BARI Masur-8 (50%) had scarce DSI. In the case of rust, BARI Masur-5 (74.00%) showed top DSI accompanied by Binamasur-8 (58.33%). The utmost seed yield of 8.25 g/plant was produced by Binamasur-10; in contrast, the least was yielded by Binamasur-8 (5.45 g/plant). Weather factors (temperature, relative humidity, rainfall) were positively related to the number of aphids per plant. However, seed yield was negatively affected by aphid population, foot rot, and rust disease incidence. Overall, Binamasur-10 corroborated having better resilience to biotic and abiotic factors for delivering desirable economic yield
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Revisiting carotenoid aggregates discerning non-covalent interaction of unbranched fatty acid analogues

Published on: 31st March, 2022

Certain carotenoid aggregates provide scaffolds of moderate stability characterized by their CD spectra. The interaction of the scaffold with small lipid molecules either destabilize, or reinforce its structure. The idea can be applied to open-chain fatty acids and some analogues. Fatty acids and fatty alcohol decrease exciton intensity of the aggregate, while esters of both alcohol and acids increase it. Moreover, the stabilizing effect depends on chain-length. Thus, the scaffold distinguishes compounds that either loosen its structure, or reinforce it.
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Fibromuscular dysplasia and aortic dissection

Published on: 30th March, 2022

Fibromuscular dysplasia is a rare, non-atherosclerotic, non-inflammatory vascular disease that typically affects women between the ages of 20 and 60 years.Although any artery can be affected fibromuscular dysplasia most commonly affects the renal and carotid arteries. Fibromuscular dysplasia of the renal arteries usually presents with hypertension, while carotid or vertebral artery disease causes transient ischemic attacks, strokes, or dissection. Aortic dissection is rare. We present the clinical case of a patient with fibromuscular dysplasia with type B aortic dissection.
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