The Role of Anemia of Inflammation in the Course of Chronic HBV Infection in Children
Published on: 2nd September, 2025
The article evaluates the features of the course of chronic HBV infection in children with the background of anemia of inflammation. A brief description of the clinical and laboratory manifestations of the disease is given, depending on the course of anemia and inflammation. The data on hepcidin dynamics are analyzed. The stage–by-stage formation of iron metabolism disorders was revealed, in the form of a true deficiency with a breakdown of ferrokinetic markers – an increase in hepcidin and soluble transferin receptors with the background reduced ferritin values characteristic of iron deficiency anemia in the initial stages of the disease and, redistributive iron deficiency - decrease in hepcidin and soluble transferrin receptors with the background increased ferritin values characteristic of iron overload the body is in the late stages of the disease.
Differences in Percentages in Osseointegration and Bone Stability between Multibody and Standard Implants
Published on: 1st September, 2025
Dental implantology represents a cornerstone of modern restorative dentistry, providing long-term functional and esthetic rehabilitation of missing teeth. The process of osseointegration—first introduced by Brånemark—refers to the direct structural and functional connection between living bone and the surface of a load-bearing implant [Brånemark, 1985].
Necrotizing Fasciitis in Neonates Case Series
Published on: 1st September, 2025
Introduction: Necrotizing Fasciitis (NF) is a rapidly progressing and life-threatening soft tissue infection, exceedingly rare but often fatal in neonates. This case series highlights the rarity, fulminant nature, and poor prognosis of neonatal NF by presenting four cases.Case presentation: Four neonates, aged 12-16 days, presented with rapidly spreading, tender, erythematous, and indurated skin lesions on their backs, initially resembling burns. Systemic symptoms like fever, lethargy, and poor feeding were common. Despite empirical antibiotics, the lesions progressed to necrosis, often with bullae formation. Microbiological cultures revealed polymicrobial growth in three cases (E. coli, Pseudomonas sp., Klebsiella, and MRSA) and monomicrobial growth of MRSA in one case, frequently exhibiting antibiotic resistance. Surgical debridement was performed in three cases. Despite aggressive management, two neonates succumbed to sepsis and multi-organ dysfunction. The other two neonates recovered after prolonged antibiotic therapy and wound care.Discussion: These cases underscore the diagnostic challenges and rapid progression of NF in neonates. The consistent presentation after 10 days of birth, rapid lesion spread mimicking burns, and predilection for the back were notable features. Polymicrobial infection was frequent. Early recognition, aggressive broad-spectrum antibiotics, and timely surgical debridement are crucial for improving the poor prognosis associated with this condition.
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