All Articles in november, 2025

Introduction: Erectile dysfunction (ED) is a common issue impacting millions of men around the globe, with notable effects on both life quality and mental health. This clinical trial evaluated the clinical efficacy, onset of action, safety, and patient satisfaction of Tadaflexe (Tadalafil 10 mg) formulated as an oral gel in Yemeni honey sachets. The formulation was designed to enhance absorption and provide a natural delivery vehicle for Tadalafil, a selective phosphodiesterase type 5 inhibitor used for erectile dysfunction (ED). This study aimed to assess the effectiveness, safety, and tolerability of Seldiflexe, which is a new oral gel sachet formulation of Tadaflexe (Tadalafil 10 mg) with 5 g of Yemeni honey, in comparison with standard Tadalafil 10 mg tablets. Materials and methods: A randomized, double-blind, controlled trial was carried out with 80 male participants who had been diagnosed with erectile dysfunction (ED). Subjects were divided into two groups: the Tadaflexe (Tadalafil 10 mg) oral gel sachet group A (n = 40) and the standard Tadalafil 10 mg tablet group B (n = 40) for a duration of 4 weeks. The main measures included changes in the scores of the International Index of Erectile Function (IIEF), time until effects began, and the profile of any adverse events.Results: The analysis revealed a statistically significant improvement in erectile function scores post-treatment with Tadaflex oral gel. The onset of action was notably faster compared to standard Tadalafil tablets. Adverse effects were minimal, and overall satisfaction was high among participants. The time it takes for Tadaflexe (Tadalafil 10 mg) in Yemeni honey oral gel sachet to start working is 22.5 ± 4.2 minutes, which is significantly faster than Tadalafil 10 mg tablets was 38.7 ± 5.6 minutes at p < 0.001. However, after four weeks, there was no significant difference in the IIEF scores between Tadaflexe oral gel (20.1 ± 2.8) and Tadalafil tablets (18.2 ± 3.1) were significantly different at p < 0.05. On the other hand, the adverse effects were significantly less with Tadaflexe oral gel sachet as compared with Tadalafil tablets.Conclusion: The study demonstrated a significantly faster onset of action, excellent tolerability, and improved patient preference compared with conventional tablet formulations.

Nosocomial infections are infections acquired during a stay in a healthcare facility, representing a major public health challenge worldwide, and particularly in Africa, due to their frequency, potential severity, and associated costs. In Congo, their epidemiological profile is not yet well understood. It’s in this context that we undertook to conduct a retrospective descriptive study on nosocomial infections between January 1, 2012, and December 31, 2016, in the internal medicine department of the Army Central Hospital of Brazzaville, in order to analyze the bacteriological profile of nosocomial infections.The study involved 189 patients. The results revealed that hospital-acquired infections were frequent, with a female predominance (71.43%), an average age of 32 years, and risk factors including self-medication with antibiotics (51%) and urinary catheterization (39%). Urinary tract infections were the most common (57%), with Escherichia coli as the main pathogen (17%), and mortality from these infections reached 53%.The study highlighted a high mortality rate linked to hospital-acquired infections, primarily associated with HIV status and self-medication. Management, prevention, and infection control measures, including improved antibiotic stewardship, are necessary to reduce mortality.

This study explores “Gyneco-Obstetric Algebraic Didactics” (GOAD), a pioneering approach fusing mathematical didactics with obstetric learning. Using inventive models such as the Ovary-Function Theorem (OFT) and the Cervix-Dilation Equation , the cognitive and emotional outcomes of teaching mathematics using obstetric metaphors are rigorously evaluated. Sixty pregnant mathematicians and sixty gynecology students participated, revealing that metaphoric teaching not only improved calculus scores by 16.5 points but also reduced birth anxiety by 13.7%. The introduction of Fibonacci-based labor charts led to an unexpected increase in affinity for abstract algebra, suggesting possible interdisciplinary applications for both education and clinical practice.

Prothrombin Time (PT), also called Quick’s Time (QT), is a coagulation test expressed in seconds, measured in the presence of tissue thromboplastin and calcium ions. Similarly, Activated Partial Thromboplastin Time (APTT) is measured in the presence of phospholipids, an activator, and calcium ions. These two tests are among the most commonly used in hemostasis. Their execution absolutely requires plasma samples used as quality controls, whether commercial or prepared locally (“pooled” in the laboratory).This descriptive study aimed to determine the stability duration of an in-house control pool for PT and APTT tests, prepared in the laboratory of the Hematology and Blood Bank service of the Yaoundé University Teaching Hospital, Cameroon.Plasma was collected after centrifugation, mixed, and then frozen at a temperature of -30 °C to preserve the coagulation factors, especially the most labile ones. The plasma pool was then aliquoted, stored at -30 °C protected from light in a domestic freezer, and kept for a period of two weeks. A portion of the pool was tested within four hours of collection: 30 PT and APTT analyses were performed.The assay was performed manually using the tube tilt method. The means obtained were 12.71 seconds for PT and 30.66 seconds for APTT. The acceptability limits (mean ± 2 standard deviations), calculated from the standard deviation, were 11.38 to 14.04 seconds for PT and 27.96 to 33.37 seconds for APTT.The plasma pool was then analyzed daily in duplicate. The average of the results for each day was plotted on a Levey-Jennings chart and interpreted according to Westgard rules. The results showed that the stability duration of the normal control pool is eight (8) days for PT and seven (7) days for APTT.In a context marked by a recurrent shortage of quality control reagents, for various logistical and economic reasons, these results offer a reliable alternative to commercial control samples, which are often expensive or unavailable. The use of locally prepared control pools could thus compensate for stock-outs of normal or pathological control reagents supplied by manufacturers.

Introduction: The document introduces the topic of medical termination of pregnancy (MTP) using misoprostol, a synthetic prostaglandin E1 analogue. It discusses the advantages and challenges of this method, and the research gap in the Gulf region and the Middle East. It also states the aim of the study, which is to evaluate the safety, efficacy, and acceptability of misoprostol for MTP in Bahrain. Methods: The document describes the study design, data source, and inclusion criteria. It explains that the data was collected from the Hope system in King Hamad University Hospital and included women in the first and second trimester of pregnancy who were undergoing MTP as per the FIGO protocol. It also mentions the statistical analysis that was used to compare the outcomes of different regimens, dosages, and routes of administration of misoprostol. Results: The document reports the main findings of the study, such as the success and failure rates of MTP, the association between previous deliveries and MTP outcomes, the optimal number and route of misoprostol doses, the length of hospital stay, and the incidence of complications. It also presents some figures to illustrate the results. Discussion: The document interprets the results and compares them with previous studies. It highlights the high efficacy of the sublingual route of misoprostol but also acknowledges the side effects and limitations of this route. It suggests that two doses of 600mcg or 800mcg of misoprostol are sufficient for MTP. It also identifies the strengths and weaknesses of the study and proposes some future directions for research. Conclusion: The document concludes that the study provides a better understanding of the outcomes of misoprostol for MTP in a controlled environment. It asserts that misoprostol is a safe and effective option for women seeking abortion in the first and second trimester, especially in low-resource settings. It also emphasizes the need for evidence-based guidelines and counseling for misoprostol use.