arthralgia

Open accessCase ReportArticle ID: apcr-aid1005Views: 21Download: 27

Predicament of classification: Multisystem small vessel vasculitis with cresentic Glomerulonephritis

Awad Magbri*, Shaukat Rashid and Balhinder Brar

Published on: 9th April, 2018

OCLC Number/Unique Identifier: 7666350132

The patient is a 28-year old Caucasian man with six month history of arthralgia and crampy abdominal pain who presented with acute dyspnea and cough for 6 months associated with migratory polyarthralgias involving his knees, ankles, wrists, and shoulders.

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Abstract DOI: 10.29328/journal.apcr.1001005 Read Full Article HTML Read Full Article PDF

Open accessCase ReportArticle ID: jcn-aid1013Views: 20Download: 17

Equine Anti-Thymocyte Globulin (ATGAM) administration in patient with previous rabbit Anti-Thymocyte Globulin (Thymoglobulin) induced serum sickness: A case report

Joseph B Pryor*, Ali J Olyaei, Joseph B Lockridge and Douglas J Norman

Published on: 23rd March, 2018

OCLC Number/Unique Identifier: 7666273824

Thymoglobulin is a rabbit-derived anti-thymocyte antibody directed at T-cells and commonly used for induction immunosuppression therapy in solid organ transplantation, especially in immunologically high risk kidney transplant recipients. Despite its frequent use and efficacy, the heterologous makeup of thymoglobulin can induce the immune system resulting in serum sickness which typically presents with rash, fever, fatigue, and poly-arthralgia in the weeks following drug exposure. ATGAM is another anti-thymocyte antibody, targeting the same epitopes, but differs from thymoglobulin by the animal in which the preparations are generated (equine vs. rabbit). Herein, we present a case of a patient with a known history of thymoglobulin-induced serum sickness, who presented with evidence of acute cellular and vascular rejection at their 12-month post-operative visit. Given their immunologically high risk status, they were successfully treated with ATGAM with improvement in their rejection and kidney function. To the author’s knowledge, this is the first case report of successful administration of ATGAM in a patient with a documented history of thymoglobulin induced serum sickness, demonstrating a possible treatment option for acute rejection in patients with reactions to thymoglobulin.

Abstract DOI: 10.29328/journal.jcn.1001013 Read Full Article HTML Read Full Article PDF

Open accessResearch ArticleArticle ID: ijcv-aid1042Views: 39Download: 51

Impact of the COVID-19 infection on the “benign” nature of the illness of Schönlein-Henoch

A Vasileva*, IV Chakarov and P Chakarova

Published on: 11th January, 2022

OCLC Number/Unique Identifier: 9391761803

The incidence of COVID-19 in children has been variable. Although now the number of infected children worldwide, and in particular nationally, is small, they are not protected from the infection. Moreover, in the most severe cases septic shock, metabolic acidosis, irreversible bleeding, and coagulation dysfunction have been registered.In February 2021 a 17-year-old boy showed for examination with complaints of pain in the upper part of the abdomen, accompanied by involvement of the ankle joints, the appearance of a rash on the lower extremities with the characteristic of hemorrhagic vasculitis, and a positive test for COVID-19. The characteristics of the skin purpura, the abdominal pain, and the arthralgia led us to the diagnosis of Schönlein-Henoch purpura. The verification of past COVID-19 infection was done by the established high titer of specific IgG antibodies. The clinical evolution of the disease went beyond its generally accepted benign nature - the first manifestation of the illness had been followed by four more relapses, which necessitated new hospitalizations and a change in the therapeutic approach.COVID-19 infection is the cause of a more aggressive course of vasculitis.

Abstract DOI: 10.29328/journal.ijcv.1001042 Read Full Article HTML Read Full Article PDF

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