aseptic meningitis

Brain changes in Hypothermia: Surface-versus Core-cooling in pigs

  • Inge Morild*, Kåre Lilleng, Stig Morten Hammersborg and Paul Husby

Published on: 31st October, 2017

OCLC Number/Unique Identifier: 7286428120

The process of hypothermia in the clinical setting has been practiced for 50 years and is known for its neuroprotective properties. This paper describes histopathological changes either by an ice sludge mimicking accidental hypothermia (S-group n=7) or by endovascular core-cooling (C-group n=7). Focal infiltrates of neutrophilic granulocytes were found in five of seven brains in the S-group and in one of seven brains in the C-group. These granulocytes were found in the arachnoids, in vessels, in vessel walls, and in the cerebral cortex. Fungi, bacteria, lymphocytes or plasma were not found. This experimental study, mimicking accidental hypothermia, reported histopathologic features of aseptic inflammation. To our knowledge, such findings have not been described in hypothermic animals or humans before. We suggest that a local inflammatory response may be triggered in such cases of hypothermia.
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AbstractDOI: 10.29328/journal.jfsr.1001011Read Full Article HTMLRead Full Article PDF

Aseptic Meningitis in Pregnancy – A Case Study Detailing Potential Diagnostic Dilemmas

  • Yan Shun NG*, Marlene Samantha Sze Minn GOH and Manisha Mathur

Published on: 14th June, 2023

There are few reported cases of meningitis in pregnancy and presentation can be variable in each patient which may cause diagnostic challenges and potential delays in treatment. Here, we discuss a case of aseptic meningitis - a 36 years old Gravida 2 Para 1 pediatric physician with “the worst headache of her life” at 31+5 weeks of gestation. At presentation, she did not have any of the classic triads of meningitis (fever, neck stiffness, and/or a change in mental status) and did not report any neurological symptoms. In view of persistent headache, development of pyrexia, and evolving symptoms of photophobia, she was referred to a neurology specialist, and a lumbar puncture was performed. Findings were in line with meningitis and the polymerase chain reaction confirmed enterovirus meningitis. Although aseptic meningitis is rare, it should be considered as a differential diagnosis in patients with persistent complaints, development of associated symptoms of pyrexia, photophobia, and neck pain, as well as in patients with increased risk of exposure to viral illnesses.
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AbstractDOI: 10.29328/journal.cjog.1001130Read Full Article HTMLRead Full Article PDF

Primary Diffuse Leptomeningeal Melanocytosis: A Rare and Challenging Diagnosis

  • Stefano Machado*, Diogo Fernandes dos Santos, Andrea De Martino Luppi, Vynícius Vieira Guimarães and Ana Cristina Araújo Lemos da Silva

Published on: 17th April, 2024

Primary melanocytic neoplasms of the central nervous system are rare entities and can present in different clinical forms with mild and non-specific symptoms (such as headache and tinnitus) to severe and limiting symptoms (focal deficits and intracranial hypertension), mimicking the most diverse pathologies. In addition to the peculiar changes in imaging tests, diagnosis is always a challenge given the multitude of possible differential diagnoses, including aseptic meningitis. Given this, we bring here the case of a 59-year-old patient who attended care due to headache and vertigo followed by involvement of the cranial nerves and spinal cord, corroborated by physical examination and imaging study suggesting diffuse involvement of the meninges, which was subsequently confirmed by anatomopathological examination as a primary melanocytic neoplasm of the central nervous system but ended up dying due to complications resulting from late diagnosis. The objective of this work is to raise awareness about the possibility of this pathology as a differential diagnosis in these cases where there are often frustrating clinical manifestations but with changes in imaging tests, to enable an early diagnosis and consequently the possibility of a better therapeutic result, in addition to a brief review of the propaedeutic findings of this pathology.
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AbstractDOI: 10.29328/journal.jnnd.1001096Read Full Article HTMLRead Full Article PDF

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