bauhinia forficata link

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Nanoencapsulated Extracts from Leaves of Bauhinia forficata Link: In vitro Antioxidant, Toxicogenetic, and Hypoglycemic Activity Effects in Streptozotocin-induced Diabetic Mice

Bárbara Verônica Cardoso de Souza, Alessandra Braga Ribeiro*, Rita de Cássia Meneses Oliveira, Julianne Viana Freire Portela, Ana Amélia de Carvalho Melo Cavalcante, Esmeralda Maria Lustosa Barros, Luís Felipe Lima Matos, Tarsia Giabardo Alves and Maria

Published on: 5th September, 2024

In this study, we evaluated the assessed the hypoglycemiant, toxicogenetic and genotoxic effects of nanoencapsulate extracts of Bauhinia forficata Link. Phytochemical evaluations of extracts were carried out, as well as the evaluation using HPLC-MS and of antioxidant capacity in vitro. DM2 was induced in mice with streptozotocin and extracts were given orally for 28 days. That dried extract from infusion (ESIN) had a higher rate of bioactive compounds compared to the dried extract from decoction (ESDC), and higher antioxidant capacity. Glucose levels decreased from 77.26% to 57.79% and 45.15% after supplementation with ESIN (200 and 600 mg/kg/day) and ESDC (600 mg/kg/day), respectively, when compared to the diabetic group treated with metformin (600 mg/kg/day) (21.53%), with an improvement in the glycemic response e recovery of pancreatic β cells. Thus, our study has shown that these extracts exhibit hypoglycemiant activity, with a beneficial effect superior to metformin, as a result they could be considered as potential therapeutic agents for application in pharmaceutical formulations in the treatment of DM2.

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Abstract DOI: 10.29328/journal.apps.1001063 Read Full Article HTML Read Full Article PDF

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