endogenous toxicology

Open accessResearch ArticleArticle ID: acst-aid1004Views: 33Download: 38

Endogenus toxicology: Modern physio-pathological aspects and relationship with new therapeutic strategies. An integrative discipline incorporating concepts from different research discipline like Biochemistry, Pharmacology and Toxicology

Luisetto M*, Naseer Almukhtar, Behzad Nili Ahmadabadi, Gamal Abdul Hamid, Ghulam Rasool Mashori, Kausar Rehman Khan, Farhan Ahmad Khan and Luca Cabianca

Published on: 14th January, 2019

OCLC Number/Unique Identifier: 7986003175

Many pathologic disease can be considered as related to an Endogenous toxicological moves and in time dependent way (kinetics and dynamic of the process). In this work starting from the analysis of relevant literature involved with different disease and related to the endogenous local micro- environment some global conclusion useful as new tools for innovative pharmacological strategies will be submitted to the researcher. Physiology, pathology concept linked to the endogenous toxicological local micro-environment status as new research instruments. The same carcinogenesis process can be related also to endogenous agents that may have a major contribution in spontaneously process. (Reactive oxygen species (ROS), which are involved in multiple cellular processes by physiologically transporting signal as a second messenger or pathologically oxidizing DNA, lipids, and proteins).

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Abstract DOI: 10.29328/journal.acst.1001004 Read Full Article HTML Read Full Article PDF

Open accessResearch ArticleArticle ID: apps-aid1025Views: 49Download: 49

COVID-19 immunologic and toxicological implication: Innate immune sensor and immune escape

Luisetto M*, Farhan Ahmad Khan, Khaled Edbey, Gamal Abdul Hamid, Mashori GR, Nili BA, Fiazza C, YesvI R and Latishev Yu O

Published on: 25th March, 2021

OCLC Number/Unique Identifier: 8980360578

Related COVID-19 and new Variant and treatment like vaccine it is relevant to deeply verify the immunologic implication and in a special way regarding the innate immune sensor system and the evasion of the immune system. This can be crucial to search for new strategies to fight this severe disease under a Toxicology-antidotes point of view. The rapid emergence of a new variant is under study by researchers because some of these show different responses to antibodies as reported in literature (vaccine efficacy?). In this article after a review part it is submitted a collection of hypothesis of solution to contrast COVID-19. Spread and mortality and project hypothesis. A new toxicological approach also in a viral respiratory disease can be a novelty to adequately fight this severe condition and this focusing not only towards specific immunity but also a specific measures. A toxicological approach in drug- vaccine like products designing makes it possible to get the clinical outcomes needed.

Abstract DOI: 10.29328/journal.apps.1001025 Read Full Article HTML Read Full Article PDF

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