For professionals working on the topic of cochlear implantation: Opinions of readers of “Instruction” and participants of MIMIC
Published on: 18th January, 2018
OCLC Number/Unique Identifier: 7355941188
To facilitate understanding some issues of cochlear implantation for new beginners we wrote 1- “The Instruction for audiologists and cochlear implanted patients” and created 2-Demo-program MIMIC. Here are opinions of readers of “The Instruction” and participants of MIMIC. All the ratings are from positive to enthusiastic.
Practical implementation of the SWEEP-session of Stimulation-Registration in CI fitting
Published on: 11th October, 2017
OCLC Number/Unique Identifier: 7325438281
Levels of electrically evoked stapedial reflex thresholds (eESRTs) are frequently used as most comfortable levels (MCL) in cochlear implant fitting. The problem of routine one-channel-technique of reflexometry is long duration of this procedure. In order to “compress the time” we suggest method of consecutive stimulation of all electrodes of implant with simultaneous registration of stapedial reflexes-SWEEP-session. Practical implementation of the SWEEP-session is described here. This method has been successfully used in several hundred CI patients. Registration of evoked electrical stapedial reflex thresholds (eESRTs) during CI fitting is long procedure. In order to “compress the time” we suggest our SWEEP-session method. Practical implementation of this SWEEP-session is described here in accordance with the patent of Russian Federation.
Synthetic Animal: Trends in Animal Breeding and Genetics
Published on: 11th January, 2019
OCLC Number/Unique Identifier: 7976985981
Synthetic biology is an interdisciplinary branch of biology and engineering. The subject combines various disciplines from within these domains, such as biotechnology, evolutionary biology, molecular biology, systems biology, biophysics, computer engineering, and genetic engineering. Synthetic biology aims to understand whole biological systems working as a unit, rather than investigating their individual components and design new genome. Significant advances have been made using systems biology and synthetic biology approaches, especially in the field of bacterial and eukaryotic cells. Similarly, progress is being made with ‘synthetic approaches’ in genetics and animal sciences, providing exciting opportunities to modulate, genome design and finally synthesis animal for favorite traits.
Changes in the frequency and intensity of Tinnitus using the Suppressive Noise Spectrum
Published on: 21st July, 2017
OCLC Number/Unique Identifier: 7325433767
Objective:To report findings of improvement in patient tinnitus intensity and changes in frequency using a novel suppressive noise spectrum.
Design: Single-subject; each subject served as his or her own control. Each patient received treatment, and changes were measured over time.
Setting: Tertiary referral via university otolaryngology and hospital audiology as well as audiology clinics in the region.
Patients: Fifteen tinnitus ears in 8 patients.
Interventions: Therapeutic and rehabilitative.
Main Outcome Measures:: Tinnitus frequency, tinnitus intensity, and tinnitus questionnaire.
Results (Findings): After 3 months of exposure to the customized suppressive noise spectrum therapy, patients showed a shift in tinnitus frequency in addition to a significant decrease in tinnitus intensity from the pre-treatment to post-treatment condition (p<0.05). Typically, improvement was gradual based on comparing 3 sets of data collected at baseline, 1.5 months and 3 months.
Conclusion: Using suppression in tinnitus is novel. Based on our findings, using a customized suppressive noise spectrum is effective in shifting the frequency, reducing the intensity of subjective tonal tinnitus, and improving the handicap based on THQ test. From this seminal report, factors related to maximizing its effectiveness (e.g., length of listening time, level of hearing loss, and application for alternative tinnitus types) may be considered for future research.
Acute Appendicitis: Hispanics and the Hamburger Sign
Published on: 20th November, 2019
OCLC Number/Unique Identifier: 8405001290
Objective: To describe the presenting clinical findings of patients with acute appendicitis and compare them with those described in the medical literature. To corroborate a common medical myth among Hispanic physicians regarding the presentation of acute appendicitis.
Methods: This was a retrospective multicenter chart review of patients diagnosed post-operatively with appendicitis after presenting to five different Emergency Departments in Southern Puerto Rico (PR).
Results: A total of 1,540 patients with pathologically confirmed cases of appendicitis were enrolled in our study. Of the study population, 45% were female, and 55% were male, and 43% were over 21 years old. Reported symptoms in our study showed that 98% of the patients had abdominal pain, 47% had nausea, and only 17.6% presented with anorexia.
Conclusion: It was our main objective to compare the presenting signs and symptoms of patients with acute appendicitis in our Hispanic population in southern PR with those found in primary medical textbooks and literature. We gathered information regarding signs and symptoms, as well as laboratory and radiographic data of patients with positive pathologic exams for appendicitis. Of the 1,540 patients with confirmed appendicitis, only 17.6% presented with anorexia. Our findings demonstrate that the rate of anorexia in the studied population is significantly lower when compared to current literature. The absence of anorexia, once considered a hallmark of appendicitis, must not lead the physician to rule out this diagnosis in the Hispanic population.
A review of research process, data collection and analysis
Published on: 11th January, 2019
OCLC Number/Unique Identifier: 7976963925
Research is the process of searching for knowledge. It is systematic search pertinent information on specific topic of interest. It is a careful investigation or inquiry especially through search for new facts in any branch of knowledge [1]. It is a scientific way of getting answers for research questions and testing hypothesis. The research question is based on uncertainty about something in the population. This can be formulated by searching different literatures from index and non index journals, books, internet, and different unpublished research work etc. A good research question should follow the FINER criteria i.e. Feasible, Interesting, Novel, Ethical and Relevant [2].
Medical bioethics vs. Medical ethics*
Published on: 21st September, 2018
OCLC Number/Unique Identifier: 7900081462
The current situation of bioethics illustrates what has become known as “the anthropological halt”, described with great lucidity by C. S. Lewis in his book The Abolition of Man as the neglect of the “Tao”, a not very extensive body of basic axioms which enable the overall integrity of reason, both in theory and practice. One of these principles, visible to everyone and which provide the cornerstones of the Judeo-Christian tradition, is the sanctity of human life.
Similarity between Some Biological Systems, Organotropism and Metastatic Process: Active Role Played By Secondary Organ?
Published on: 19th June, 2018
OCLC Number/Unique Identifier: 7757049040
According to literature, about 90% of death from cancer is related to metastasis. Metastatic process present many similarity to some other biological processes. Once we have examined some relevant biomedical literature, by understanding the real causes of metastasis, it would become much more possible to introduce new therapeutic strategies to delay or in some cases even to stop this kind of killer process. Breast cancer, as an example, produces metastasis to different organs, which seems to be related to the subtype. We believe that a deep understanding of the roles of breast cancer cells and their interactions with the liver microenvironment in early breast cancer metastasis could be a crucial factor for the design and development of effective BCLM breast cancer liver metastases therapeutic strategies and to better understand the general process. Let’s suppose the secondary organ or organs can be considered as incubator/s for the primary metastatic cells. What kind of consequences we can have in therapy field if there is an active regulating role in determining the location of secondary cancers?
Let’s observe the role played by liver, bone marrow, CNS central nervous system, lungs, lymphocytes and other secondary locations/organs a little bit closer or maybe from a different angle let’s suppose we try to come up with just a hypothesis. Just let’s take this as a possibility, and we take the thread to see where it takes us.
A possible Etiology and new treatment of Burning Mouth Syndrome and allied condition
Published on: 27th June, 2017
OCLC Number/Unique Identifier: 7325078885
Introduction: Burning mouth syndrome, oral sub mucous fibrosis, leukoplakia, etc are the different manifestations of a common disease as per the surmise of various authors. There is no known cause and no specific treatment. Attempt is made in this study to find a cause and if possible, a treatment.
Materials and methods: 38 such cases were taken up in this study. It was found, that the cardinal signs of paucibacillar indeterminate form of Hanseniasis, as per the definition of WHO, are present in all these cases. Also they are found to respond well to the anti-leprotic drugs prescribed by WHO for the Hanseniasis.
Conclusion: It is recommended for multicentre trial and further research on this score which would relieve the suffering millions of the world populations.
Medicinal plant Potentilla fulgens and its effect in vitro against Fasciola gigantica
Published on: 13th May, 2021
OCLC Number/Unique Identifier: 9272395334
Fascioliasis is a one of the most important serious parasitic zoonotic disease which caused by trematode giant liver fluke Fasciola hepatica and F. gigantica among cattle’s and humans. The infection of Fasciola can be control by the use of phytochemicals as anthelmintic components. The anthelmintic activities of dried root powder of medicinal plant Potentilla fulgens and their different preparations (organic extracts and column purified fraction) are uses in vitro against liver fluke F. gigantica. The dried root powder, different organic extract, and column fractions were time and concentration-dependent. Among all the organic extracts, ethanol extract was high toxic than other organic extracts. The toxic effect of ethanolic extract of P. fulgens after 2h exposure the LC50 value is 5.22 mg/ml against F. gigantica. The column purified fraction of dried root powder of P. fulgens shows more toxicity. The 2h LC50 of column purified fraction was 3.25 mg/ml whereas in 8h exposure the LC50 is 1.24 mg/ml. The phytochemicals of the P. fulgens may be used as anthelmintic components against liver fluke F. gigantica.
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