Evidence of woven bone formation in carotid artery plaques
Published on: 5th January, 2021
OCLC Number/Unique Identifier: 8877223434
Objective: Plaque morphology plays an important prognostic role in the occurrence of cerebrovascular events. Echolucent and heterogeneous plaques, in particular, carry an increased risk of subsequent stroke. Depending on the quality of the plaque echogenicity based on B-mode ultrasound examination, carotid plaques divide into a soft lipid-rich plaque and a hard plaque with calcification. The aim of this study was to investigate structural changes in the basement membrane of different carotid artery plaque types.
Patients and methods: Biopsies were taken from 10 male patients (average age; 75 + 1 years) and 7 females (68 + 3 years). The study population included patients suffering from a filiform stenosis of the carotid artery, 8 patients with acute cerebrovascular events and 9 with asymptomatic stenosis. Scanning electron and polarised light microscopic investigations were carried out on explanted plaques to determine the morphology of calcified areas in vascular lesions.
Results: By means of scanning electron microscopy, multiple foci of local calcification were identified. The endothelial layer was partially desquamated from the basement membrane and showed island-like formations. Polarised light microscopy allows us to distinguish between soft plaques with transparent structure and hard plaques with woven bone formation.
Conclusion: The major finding of our study is the presence of woven bone tissue in hard plaques of carotid arteries, which may result from pathological strains or mechanical overloading of the collagen fibers. These data suggest a certain parallel with sclerosis of human aortic valves due to their similar morphological characteristics.
Risk co-factors inducing malignant transformation of oral lichen planus: A literature review of clinical studies
Published on: 14th October, 2021
OCLC Number/Unique Identifier: 9324280980
Oral lichen planus (OLP) is an autoimmune chronic inflammatory disease. The potential risk of malignant transformation in OLP remains controversial. The aim of the present study was to review original clinical studies published in indexed databases, which assessed the potential risk cofactors which were implicated in the malignant transformation of oral lichen planus. We focused our search to include most of the studies that reported malignant transformation of oral lichen planus using different combinations of the following key indexing terms: oral lichen planus, malignant transformation, smoking, alcohol, chronic inflammation, candida, human papillomavirus (HPV), hepatitis C virus (HCV) and immunosuppression. The animal studies were excluded from our study. Despite a dearth of studies on this topic we have identified consumption of tobacco and/or alcohol, the presence of erosive and/or atrophic areas, infection with candida, HCV, HPV, and immunosuppression as significant cofactors. Patients with OLP with these risk co-factors are at risk of malignant transformation should, therefore be followed up for an extensive period or even for life.
Extraction of DNA from face mask recovered from a kidnapping scene
Published on: 7th January, 2022
OCLC Number/Unique Identifier: 9395237994
Deoxyribonucleic acid (DNA) extraction has considerably evolved since it was initially performed back in 1869. It is the first step required for many of the available downstream applications used in the field of molecular biology and forensic science. Blood samples is one of the main body fluid used to obtain DNA. This experiment used other body fluids such as saliva, sweat tears and mucus. There are many different protocols available to perform nucleic acid extraction on such samples. These methods vary from very basic manual protocols to more sophisticated methods included in automated DNA extraction protocols. This experiment used extraction kit (Zymo research). The DNA result from isolated saliva samples on the facemask range from 133.7, 213.6, 599.1 and 209.1 mg/ml. theoretically; such DNA is of much quantity and quality and can be used for forensic investigation when recovered from a crime scene. The DNA from isolated tears samples on the face mask ranges from 707.7, 202.5, 99.2, and 62.6 mg/ml. Theoretically, such DNA is of much quantity and quality and can be used for forensic investigation when recovered from a crime scene. The DNA from isolated tears samples on the face mask ranges from 615.3, 66.2, 78.5, and 68.2 mg/ml. theoretically, such DNA is of much quantity and quality and can be used for forensic investigation when recovered from a crime scene. Extracted DNA from saliva and sweat produced visible bands on agarose gel, mucous stain produce obscure band on agarose gel and the tears stain produce invisible bands. DNA from sweat satin, saliva stain, mucus stain and tears stain in face mask can be used as alternative for forensic investigation.
Agaricus brasiliensis (Sun mushroom) and its therapeutic potential: A review
Published on: 10th January, 2022
In recent decades, the chemical, nutritional, and functional properties of edible mushrooms have attracted considerable attention, resulting in numerous reports on their health-associated benefits. One among such edible mushrooms, Agaricus brasiliensis, is native to Brazil and is an important food supplement. This review discusses the therapeutic potential of Agaricus brasiliensis and summarizes the current studies on this edible mushroom.
The Role of Advanced Imaging in Paediatric Cardiology: Basic Principles and Indications
Published on: 24th June, 2023
Tissue Doppler Imaging and Speckle Tracking Echocardiography are newer echo-cardiographic modalities, that assess myocardial and valvular function in congenital and acquired heart diseases in childhood. In addition, cross-sectional imaging including Cardiac Magnetic Resonance (CMR) and Cardiac Computed Tomography has been widely used over the last decade in paediatric cardiology, in order to evaluate intra-cardiac and extra-cardiac anatomy. Cardiac Magnetic Resonance particularly allows detailed analysis of myocardial function, and shunt quantification and has applications even in fetal life. This mini-review summarizes the basic principles of the above-advanced modalities and highlights their main indications and clinical applications in childhood.
A Study of Complete and Incomplete Reactions of 12C + 169Tm System at Energy Range ≈ 4.16 –7.5 MeV/Nucleon
Published on: 26th June, 2023
An attempt was made in this study to measure the excitation functions of 169Tm(12C, 4n)177Re, 169Tm(12C, 5n)176Re, 169Tm(12C, αn)176Ta, 169Tm(12C, α2n)175Ta, 169Tm(12C, α3n) 174Ta, 169Tm(12C, α4n)173Ta and 169Tm(12C, 2α2n)171Lu reaction channels populated in the interaction of 12C projectile with 169Tm target were considered in order to investigate the mechanisms of complete and incomplete fusion reactions. The theoretically predicted excitation functions using the PACE4 code were compared with the previously measured excitation functions. For non α emitting channels cross-section values predicted by PACE4 in general were found to be in good agreement with the experimentally measured values. However, for α-emitting channels, the measured cross-section values were found to be higher than the values predicted by PACE4. The observed disagreement may be credited to projectile break-up in the vicinity of n-n interaction.
Persistent Bilateral Vocal Cord Paralysis Following Unilateral Basal Ganglia Hemorrhage
Published on: 18th January, 2024
Post-stroke vocal cord paralysis is a condition much less recognized compared to dysphagia. We describe bilateral vocal cord palsy in a thirty-six-year-old man following a stroke.
Sequence-independent single-primer-amplification (SISPA) as a screening technique for detecting unexpected RNA viral adventitious agents in cell cultures
Published on: 12th March, 2021
OCLC Number/Unique Identifier: 8982622827
The sequence-independent, single-primer amplification (SISPA) enables the random amplification of nucleic acids, allowing the detection and genome sequencing of different viral agents. This feature of SISPA method provides evidence for application of it in monitoring the presence of adventitious RNA viruses in cell cultures. We evaluated SISPA method for the detection of a challenge RNA virus representing adventitious agent in cell cultures. Besides, by optimizing the SISPA method in our laboratory, we found false-positive results on negative control lanes in electrophoresis gels. To investigate the sources of contamination, false-positive results of SISPA were cloned into Escherichia coli cells, sequenced, and phylogenetically analyzed. This data revealed that the SISPA method can be used as an adjunct method to confirm the absence of unexpected adventitious RNA viruses in cell cultures. The phylogenetic analysis of SISPA contaminant sequences showed that the false-positive results were caused by nucleic acid amplification of commercial cDNA synthesis kit reagents, probably tracing back to expression plasmids and host ribosomal sequences, used for the production of enzymes. Therefore, laboratories using random amplification methods must be constantly aware of the potentials of such contaminations, yielding false-positive results and background noise in the final NGS reads.
The choice of optimal modern muscle relaxants (rocuronium bromide, atracurium besilate and cisatracurius besilate) in one-day surgery in children
Published on: 15th June, 2020
OCLC Number/Unique Identifier: 8633140096
The choice of the optimal muscle relaxant in one-day surgery in children with “small” surgical interventions remains relevant to this day. In modern pediatric surgery, the requirements for the quality of muscle relaxation are highest. However, along with the effectiveness of the drug, its duration and controllability of the action, as well as the safety of use, are important [1-7].
The aim of the study: To determine the pharmacoeconomic rationale for the rational use of muscle relaxants, depending on the duration of operations in one-day surgery in children.
Material and research methods: The study was conducted in surgical clinics of the Azerbaijan Medical University. The study included 156 children who were operated on routinely from 0 to 16 years old (risk of anesthesia I-II ASA), who used combined endotracheal anesthesia during surgery. Based on the requirements of the GCP international program (Good Clinical Practice), the inclusion of children in the study was carried out only after the written consent of the parents. The studied patients were divided into 3 groups depending on the muscle relaxant used: IA (n = 52) - rocuronium bromide (esmeron), IB (n = 52) - atracurium besilate (tracrium), IC (n = 52) - cisatracurius besilate (nimbex). Depending on the type of general anesthesia, these groups were also divided into 2 subgroups: anesthesia based on isoflurane + fentanyl ″ + iso ″ and anesthesia based on sevoflurane + fentanyl ″ + sev ″. The main groups were also divided into 2 age subgroups: children under 2 years of age – IA1, IB1, IC1 and children from 2 to 16 years old – IA2, IB2, IC2.
Differential roles of trithorax protein MLL-1 in regulating neuronal Ion channels
Published on: 8th September, 2021
OCLC Number/Unique Identifier: 9244745887
Repressive regulation of potassium channel genes by Polycomb group (PcG) proteins contributes to PcG protein-mediated neuroprotection against neuronal ischemic injury, as seen in an ischemic stroke. Here we asked the question whether Trithorax group (TrxG) proteins, the antagonistic partners of PcG proteins (i.e, epigenetic activators targeting the same genes) may also regulate potassium channels. Results of patch-clamp studies on cultured neuronal cells showed that inhibition of TrxG protein MLL-1 led to an increase in potassium channel activity, an unexpected effect for a presumed gene activator. In contrast, decreased sodium currents were observed with MLL-1 inhibition. Increased or decreased levels of potassium channel protein Kv2.1 or sodium channel protein Nav1.2, respectively, were seen with MLL-1 inhibition, as determined by immunocytochemistry. These results, for the first time, demonstrate an involvement of TrxG protein MLL-1 in regulating neuronal ion channels, potentially repressing potassium channel genes.
Search by University/Institution
Enter your University/Institution to find colleagues at HSPI.
Ensuring author's satisfaction with
- Friendly and hassle-free publication process
- Less production time of articles
- Constructive peer-review
- Enhancing journal reputation
- Regular feedback system
- Quick response to authors' queries
Most Viewed Keywords
- Black gram varieties
- Allogeneic hematopoietic cell transplantation
- Citrus
- (p,q) – calculus
- Clupeids and Danish fish meal
- Febril illness
- Poverty
- Rheumatic heart disease
- Edema ex vacuo
- Salivary cortisol
- Liver fibrosis
- Pollinosis
- Endogenous toxicology
- RBD domain
- Custom tray
- Basic density
- Nano-silica
- Anxiety
- Siblings
- Alcoholism
Search Articles by Country
Get all latest articles in all Heighten Science Publications Inc journals by country.
Testmonials
To the editorial team at HSPI and the Journal of Clinical Nephrology: Thank you so much for your hard work and collaboration in bringing our article to life. Your staff was responsive, flexible, and ...
Alejandro Munoz
In my opinion, you provide a very fast and practical service.
Ahmet Eroglu
Publishing with the International Journal of Clinical and Experimental Ophthalmology was a rewarding experience as review process was thorough and brisk. Their visibility online is second to none as...
Elizabeth Awoyesuku
I was very pleased with the quick editorial process. We are sure that our paper will have great visibility, among other things due to its open access. We believe in science accessible to all.
Anderson Fernando de Souza
We appreciate your approach to scholars and will encourage you to collaborate with your organization, which includes interesting and different medical journals. With the best wishes of success, creat...
Ivano- Frankivsk National Medical University, Ukra...
Nataliya Kitsera
I am glad to submit the article to Heighten Science Publications as it has a very smooth and fast peer-review process, which enables the researchers to communicate their work on time.
Anupam M
"It was a pleasure to work with the editorial team of the journal on the submission of the manuscript. The team was professional, fast, and to the point".
NC A&T State University, USA
Moran Sciamama-Saghiv
“The choice to submit the forensic case study to the Journal of Addiction Therapy and Research was dictated by the match between the content and the potential readership. The publication process pro...
Ph.D, Boston University Department of Communicatio...
Elisabeth H. Wiig
Submission of paper was smooth, the review process was fast. I had excellent communication and on time response from the editor.
Ayokunle Dada
Thanks you and your colleague for the great help for our publication. You always provide prompt responses and high quality of service. I am so happy to have you working with me. Thanks again!
Diana (Ding) Dai
Browse by Subjects
Chemistry Group Journals
Pharma Group Journals
Mathematics & Physics Group Journals
Clinical Group Journals
- Archives of Food and Nutritional Science
- Annals of Dermatological Research
- International Journal of Clinical Microbiology and Biochemical Technology
- Journal of Advanced Pediatrics and Child Health
- Journal of Pulmonology and Respiratory Research
- Insights in Clinical and Cellular Immunology
- International Journal of Clinical Anesthesia and Research
- Journal of Clinical Intensive Care and Medicine
- Journal of Clinical, Medical and Experimental Images
- Journal of Neuroscience and Neurological Disorders
- Insights in Veterinary Science
- Journal of Stem Cell Therapy and Transplantation
- Archives of Asthma, Allergy and Immunology
- Journal of Child, Adult Vaccines and Immunology
- Archives of Cancer Science and Therapy
- Clinical Journal of Nursing Care and Practice
- Annals of Clinical Gastroenterology and Hepatology
- Journal of Hematology and Clinical Research
- Archives of Pathology and Clinical Research
- Annals of Clinical Hypertension
- Journal of Oral Health and Craniofacial Science
- International Journal of Clinical and Experimental Ophthalmology
- Journal of Radiology and Oncology
- Journal of Clinical Nephrology
- Archives of Clinical and Experimental Orthopaedics
- International Journal of Bone Marrow Research
- International Journal of Clinical Virology
- New Insights in Obesity: Genetics and Beyond
- Advanced Treatments in ENT Disorders
- Journal of Clinical Advances in Dentistry
- Insights on the Depression and Anxiety
- Heighpubs Otolaryngology and Rhinology
- Clinical Journal of Obstetrics and Gynecology
- Archives of Surgery and Clinical Research