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Introduction: Contact of health care workers and patient at health facility lead to the transmission of pathogenic organisms to each other. Hospital acquired infection prevention is standardized guide lines contain multitude protocols needed to be implemented by health care workers to reduce hospital acquired infections. Objective: To assess health care workers knowledge, attitude and practice towards hospital acquired infection prevention at Dessie referral hospital. Method: Institutional based cross sectional study was conducted among health care workers. The subjects were selected by proportional allocation in each respective department and simple random sampling method was employed. Statistical package for social sciences (SPSS) was used to analyze the data and presented in frequency tables and graph. Results: 191 study subjects were participated in the study which gives a response rate of 90.5% from 211 total sample sizes. The study subjects had given their response according to self-administered questioner. The result indicates that 86.4%, 76.4% and 77% of respondents had good knowledge and favorable attitude and poor practice towards hospital acquired infection prevention respectively. Conclusion: Even though the majority of the health care workers had good knowledge and favorable attitude, more than two third of them had poor practice towards hospital acquired infection prevention. Therefore health workers should strictly follow hospital acquired infection prevention guidelines. Improving sustainable supplies like personal protective equipment, water supply and hand washing facilities at patient care site is vital to correct the poor practice of infection prevention.

The barium is often used in radiocontrast examinations of the digestive system because of mucosal absorption is limited. Massive barium aspiration is a rare complication, especially when there is no anatomic or neurological deficit. The depending on barium concentration can cause various lung effects. When the literature is reviewed, barium aspiration may be asymptomatic or lethal in massive amounts. Rarely, large amounts of barium sulphate are aspirated into the lung, there is no literature study how often this is happening. We present a case of massive barium aspiration in this subject. The case is related to a patient’s diagnostic esophagography who complaints swallowing problems. The massive barium aspiration couldn’t notice because of the absence of acute symptoms and surgical operation of gastrointestinal tract which the patient had undergone previously. When the patient applied our Pediatric Chest Diseases Polyclinic after three months, as a result of the examinations and deep research it was understood that the case was about massive barium aspiration. The patient was directed to our center because there was a radiological appearance of bone density signs on chest X-ray. Such a complaint was not reported by the family neighter in his biography, nor was written in the epicrisis. We will share acute and chronic changes in the lungs, diagnosis and treatment approaches of this case. The infant who has ileostomy was previously operated because of necrotizing enterocolitis. And also still has severe gastro-esophageal reflux and under conservative and medical treatment, a possible fundoplication surgery is planning.

Bronchiolitis obliterans (BO) is an infrequent clinical syndrome characterized by the chronic obstruction of small airways due to fibrosis [1]. Intravenous immunoglobulin (IVIG) could be used for treatment while underlying immune mechanisms in the pathogenesis of BO exist [2]. Here, we present two children with BO due to adenovirus infection whose complaints resolved after IVIG replacement.

A prospective cross-sectional study of diabetic patients registered at the Eye department of Tobruk Medical Center in Tobruk-Libya between (01.06.2023 to 29.02.2024). At the same time data was collected in the eye department in Alwahda Derna Teaching Hospital, Data was collected using the same administered questionnaire. Grading of DR was done by slit-lamp examination and Fundoscopy by an ophthalmologist. Descriptive analysis included percentage mean, median, and p - value by using SPSS 25. There were 185 diabetic patients, ages ranging between 30 and 90 years, with a mean of 58, the majority (97.6%) were of Libyan nationality. There were 86 males and 99 females. Patients with a duration of diabetes ranging between 11 and 15 years were at almost a five-fold risk of developing DR compared to those with a duration of < 10 years. Most of advanced complicated diabetic retinopathy cases had diabetes for more than fifteen years, and no advanced disease in the cases with a duration of less than 10 years.

Insulin resistance, often referred to as impaired insulin sensitivity. This clinical case focusses on a woman with insulin resistance and a long-standing and recurring history of obesity to demonstrate how diet therapy can be applied in addition to standard medication therapy.

Asthma is a highly prevalent airway disease with multiple phenotypes [1,2]. Adult-onset eosinophilic asthma is a severe asthma subtype associated with more frequent and severe exacerbations, the development of persistent airflow limitation and a poorer quality of life. This type of asthma is much more difficult to control than other asthma subtypes, requiring high doses of inhaled or even oral corticosteroids (OCS) [3,4]. Recently, several new monoclonal antibody therapies have been approved for eosinophilic severe asthma, including anti-IL-5 treatment. IL-5 is essential for eosinophilic maturation and survival [5] and anti-IL5 treatment has markedly reduced asthma exacerbations with sparing of OCS use in patients with eosinophilic asthma [6]. Eosinophilic asthma is frequently associated with chronic rhinosinusitis and/or nasal polyposis [7], suggesting that a similar eosinophilic inflammatory process might drive both conditions. Eosinophilic otitis media (EOM) also might fit in this concept, showing remarkable similarities with asthma and nasal polyposis. The disease was first reported in 1994, but only since 2011 diagnostic criteria for EOM were identified. If a patient shows otitis media with effusion or chronic otitis media with eosinophil-dominant effusion (major criterion) and is being positive for ≥2 items of the 4 minor criteria (highly viscous middle ear effusion, resistance to conventional treatment, association with asthma, association with nasal polyposis) he is diagnosed as having EOM. Eosinophilic granulomatosis with polyangiitis and hypereosinophilic syndrome must be excluded [8].

Introduction: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Bacillus of Koch), and presents chronic evolution affecting the lungs frequently. Objectives: Analyse, in the state of Maranhão, the epidemiological prevalence of tuberculosis between 2014 and 2016. Materials and Methods: Documentary and descriptive study of secondary data collected in the database of the dates, epidemiological information and morbidities, between 2014 and 2016. Results: 3,897 cases of tuberculosis in the state of Maranhão were recorded. The most affected age range was 15 to 59 years, totaling 3,111 cases, for both gender; of 60 to 79 years, 577 cases were totaled. Conclusion: Tuberculosis affects more adolescent males from adolescence to old age, and it is necessary to promote knowledge of the disease for the population in order to advance in the control of the same and obtain satisfactory clinical results.

The capabilities approach, based on the work of Sen and Nussbaum, proposes a transformation in housing design by prioritizing human well-being over economic criteria. This framework assesses individuals’ real opportunities to develop fulfilling lives (“capabilities”), responding to contemporary challenges such as climate change and urbanization. Recent studies indicate that 68% of architects integrate this approach into sustainable projects (Chen, et al. Journal of Sustainable Architecture, 2023, Q1), demonstrating its relevance for creating resilient and inclusive environments. The methodology combines theoretical analysis (UTAUT model for technology adoption and the capabilities approach) with global case studies. Designs are examined that incorporate: Smart technology: IoT and AI systems for security and energy efficiency; Biophilic design: Integrating nature into interior spaces; and Net-Zero Homes (NZEH): Energy self-sufficiency through renewables. Data were collected from projects in Belgium, Australia, and the US, assessing social and environmental impact using well-being and sustainability metrics. We determined the results and discussed the approach using Positive Impact: Smart-technology homes improve autonomy in older adults by 72% (Liu, et al. Gerontology, 2022, Q1). Projects such as Savonnerie Heymans (Brussels) reduced energy consumption by 40% through solar panels and thermal insulation, while increasing social cohesion with community spaces. Biophilic design: Associated with 30% less stress and 25% higher productivity; Barriers: High initial costs (up to 20% more than conventional housing) and regulatory complexity limit widespread adoption. Furthermore, feminist and decolonial critics warn that the approach can perpetuate inequalities if it ignores sociopolitical contexts. In conclusion, the capabilities approach revolutionizes future housing by merging human well-being, sustainability, and inclusion. However, its implementation requires overcoming economic and ethical challenges: Accessibility: Universal designs for vulnerable populations. Collaborative governance: Policies that balance innovation, data privacy, and affordability. Cultural adaptation: Integration of non-Western perspectives. Projections indicate that NZEHs will grow by 40% by 2030, highlighting their potential to build equitable and resilient societies.

Modern Agricultural production wants to efficiently produce plant products and benefits to meet people's needs. However, because of better plant species and varieties, overuse of fertilizer and overdose of pesticide alters the plant resources relationship, resulting in soil degradation, vegetation decline, and crop failure or waste of resources, which influence the quality of fruit and benefit and are unfavorable for the sustainable utilization of nature resources and crops high-quality development. After a couple of years of study, the results showed that Agricultural development went into agricultural high-quality development in 2017, which is to use effective measures or methods to maximize yield and benefits and meet the need of people's need for better Agricultural produce and a better life. The theory foundation of the sustainable utilization of natural resources and Agriculture high-quality production is the resources use limit by plants, vegetation carrying capacity, and critical period of plant resources relationship regulation. The methods of Agriculture high-quality development are to select excellent plant species or varieties based on site conditions and market needs before planting crop young plants and sowing seeds, adopt appropriate initial planting density when planting crop young plants and sowing seeds, and regulate the relationship between plant growth and resources need in the process of crop production in a timely and appropriate amount, especially the chemical fertilizer and pesticide to obtain the maximum yield and benefits and realize the sustainable utilization of natural resources and achieve agricultural high-quality development.

We describe here the case of a 23-year old woman with small cell carcinoma of the ovary of the hypercalcemic type (SCCOHT) with SMARC-A4 mutation who benefited from surgery in two steps leading to a total hysterectomy with bilateral salpingo-oophorectomy, omentectomy, pelvic and lombo-aortic lymph nodes dissection. She also received 6 courses of poly-chemotherapy after the surgery. A close follow-up was then performed by clinical examination every three months with determination of serum calcium and CA125 level as well as imaging with thoraco-abdominal CT scan. To date, the patient has a disease-free survival of more than 9 years. We also reviewed the literature on this topic and discuted the new diagnostic and prognostic genetic tool SMARC-A4 mutation.