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Background: Atrophic scars following acne vulgaris are considered an aesthetic, psychological, and social problem for patients, and despite the existence of many treatment options, finding modern treatments is a necessity to reduce side effects associated with current therapies and reduce the financial burden on patients.Objectives: to evaluate the efficacy of punch elevation combined with dermapen in treating atrophic scars following acne vulgaris on the cheeks, and to evaluate patients' satisfaction with this procedure.Methods: This clinical trial involved 19 patients to evaluate the efficacy of punch elevation combined with dermapen in treating post-acne scars.Results: According to the Goodman and Baroon scale for acne scars, and after 6 months, the percentage of grade 4 decreased from 26.3% to 10.5%, grade 3 decreased from 73.7% to 31.6%, grade 2 increased from 0% to 52.6%, and grade 1 increased from 0% to 5.3%. p - value was less than 0.005, indicating a relationship between the degrees of atrophic scars on the Goodman-Baron qualitative scale after 6 months of treatment. According to the improvement scale, good improvement was 10.5%, acceptable improvement was 57.9% and no improvement was 31.6%. Patients were satisfied with the procedure after 3-6 months according to the modified Global Aesthetic Improvement Scale for Patient Evaluation.

The 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM guideline for the prevention, detection, evaluation, and management of arterial hypertension introduces important updates compared with the 2017 version. Given the global impact of hypertension as a major cause of cardiovascular morbidity and mortality, and the coexistence of multiple international and national recommendations, the Mexican Expert Group on Arterial Hypertension (GREHTA) conducted a structured review and comparative analysis. We contrasted the 2025 AHA/ACC recommendations with those of the European Society of Hypertension (ESH 2023), the European Society of Cardiology (ESC 2024), the Latin American Society of Hypertension (LASH 2024), and the National Medical Care Protocol of Mexico (PRONAM 2025). Our goal is to provide clinicians with a clear, evidence-based synthesis to guide practical decision-making. Key topics include definitions and thresholds, diagnostic methods, cardiovascular risk stratification, therapeutic strategies, special populations, and resistant hypertension. GREHTA emphasizes a pragmatic, regionally adapted approach, highlighting early combination therapy, risk factor integration, and systematic follow-up.

One of the most important and critical red blood cell disorders is dysfunction and deformation of the membrane structure, which affects the metabolic and biological red blood cell functions. On the other hand, the basic causes of these problems are the genetic mutations in the production of proteins that correlate to the structure and receptors of cells. The diagnosis methods and techniques are the other essential points that focus most scientists on. In this systematic review, the article pointed to the key title, which is the diagnosis of novel genes with different techniques and methods. The result of articles studies that were published in the last decades underlined the types of techniques such as Whole-Exome Sequencing, Quantitative Real-Time PCR, Targeted Next-Generation Sequencing, and Sulphate-Polyacrylamide Gel, which investigated the different membraned gene mutations that are novel and correlated to the genes that make the structures and functions of red blood cells such as hereditary spherocytosis, hereditary elliptocytosis, hereditary pyro poikilocytosis. In addition, the hereditary membrane disorders correlated to others, such as hereditary spherocytosis, have a relationship with vitamin B12, immunodeficiency.

Introduction: Forensic odontology is a specialized field at the crossroads of dentistry and law, focusing on the analysis of dental evidence in legal investigations. Due to their resistance to decay and environmental degradation, teeth serve as a vital resource in age estimation and gender determination. Various techniques, including microscopic examination of the incremental lines in enamel and cementum, neonatal lines, and dentin translucency, are commonly employed for forensic analysis. To enhance the accuracy and ease of examination, there is an increasing demand for high-quality, non-demineralized tooth sections that are durable, easy to handle, and maintain uniform thickness. Aims and objectives: 1. Evaluate the effectiveness of the Rosin stain in identifying incremental lines in hard dental tissues. 2. Compare Rosin stain with Haematoxylin and Eosin stain as well as with unstained sections. Materials and methods: Sixty sound teeth were included in the study. Thin longitudinal sections of 2 mm were prepared using a diamond disc, and ground sections of 25 µm were prepared on Arkansas stone. The sections were divided into three groups: (A) sections stained with Rosin, (B) sections stained with H&E, and (C) unstained sections. The longitudinal ground sections were examined under both the Light Microscope and the Phase Contrast Microscope. The Microstructures of the teeth, such as incremental lines of enamel, dentin, and cementum, were assessed.Result  and conclusion: Rosin-stained ground sections observed under phase contrast microscopy provided better visualisation of dental microstructures than unstained or H&E-stained ground sections, suggesting Rosin enhances the identification of incremental lines in forensic dental analysis.

With the rapid shift to telemedicine during the COVID-19 pandemic, clinicians have faced unprecedented demands in adapting to prolonged virtual consultations. This has given rise to “Zoom fatigue,” a form of mental and emotional exhaustion associated with extended video-based interactions. While the Zoom Exhaustion and Fatigue Scale (ZEFS) has been widely applied in studies involving students and office workers, there is limited research on its relevance to clinicians. Physicians, in particular, often conduct hours of uninterrupted virtual patient care, which can potentially lead to significant neurocognitive strain. This study explores the impact of prolonged virtual consultations on clinician well-being, employing ZEFS alongside the Depression, Anxiety, and Stress Scale (DASS-21) and Satisfaction with Life Scale (SWLS) to assess emotional and cognitive outcomes. Findings suggest that the increased cognitive load, reduced non-verbal communication, and digital interface stress contribute to higher levels of fatigue, anxiety, and dissatisfaction, highlighting the urgent need for systemic support and ergonomic telehealth practices.

Bifurcation analysis and Multiobjective Nonlinear Model Predictive Control (MNLMPC) calculations were performed on a model of circadian oscillations of the Period (PER) and Timeless (TIM) proteins in Drosophila. The MATLAB program MATCONT was used to perform the bifurcation analysis. The optimization language PYOMO was used along with the state-of-the-art global optimization solvers IPOPT and BARON for the MNLMPC calculations. The bifurcation analysis revealed oscillation causing Hopf bifurcations while the MNLMPC calculations revealed the existence of spikes in the control profiles. Both Hopf bifurcation points and the control profile spikes were eliminated using an activation factor involving the hyperbolic tangent function.

Background: Plain X-rays are frequently utilized as diagnostic radiological procedures. However, their usefulness can change based on the situation, such as rib fractures. Moreover, the lack of a uniform procedure in medical facilities, poor image quality resulting from operator error or insufficient training, financial incentives, and insurance reimbursement regulations can all contribute to an overuse of X-rays. Aim: This study presents the changes in the use of X-rays over the past five years (2019-2023) in the Oman Ministry of Health institutions and identifies interventions that assist in the improvement of the quality of care and patient satisfaction. Methods: The study used a mixed-method design, integrating quantitative (retrospective cross-sectional) and qualitative data collection and analyses. Quantitative data were collected from the Nabdh Al-Shifa and the annual health report over five years. Focus group interviews were used for Qualitative data collection. Results: a positive core relationship exists between population size and use of X-rays, and there were underlying contributing factors for over X-rays. The rate at which X-ray consumption has increased over the last two years has been deemed reasonable based on several variables, such as shifts in clinical practice or population growth. Conclusion: This study demonstrated that patients aged from 0-4 years had the highest X-ray utilisation service rate over the past five years, which raises concerns about the long-term risks associated with repeated radiation exposure. Clinical rotations and appropriate training for physicians at primary health care institutions, and strategies to reduce the significant financial implications, are recommended to address the high rate of X-ray utilisation.

Chimerism is a biological condition in which a single individual harbors two or more genetically distinct cell populations originating from different zygotes. This phenomenon may occur naturally due to errors during fertilization or early embryonic development, or it may arise artificially following medical interventions such as hematopoietic stem cell transplantation (HSCT) or in vitro fertilization (IVF). Chimerism is broadly categorized as natural or artificial, and its presence presents significant challenges in both clinical and forensic contexts. In transplant recipients, the coexistence of donor- and host-derived cells can generate misleading genetic test results and complicate post-transplant monitoring. In forensic investigations, individuals with mixed DNA profiles may be difficult to identify accurately, as standard genetic fingerprinting technologies can yield inconclusive or erroneous findings. These complications underscore the necessity of reliable detection methods capable of identifying and differentiating chimeric cell populations. This review consolidates current knowledge regarding the classification of chimerism and the available diagnostic techniques, emphasizing that improved understanding of this condition is essential for enhancing diagnostic precision, optimizing forensic identification, and minimizing the risk of misinterpretation that may adversely affect medical decisions and legal determinations.

A study reports a novel synthesis of pure copper and the effect of laser energy on optical properties and the particle size of colloidal copper nanoparticles prepared by pulsed laser ablation in liquid (PLAL). Different laser energies (600,700,800 mJ) of pulsed laser (Nd: YaG) were used to prepare colloidal copper nanoparticles size of about (40.4 nm - 91.3 nm) which were measured using Field Emission Scanning Electron Microscopy (FESEM). The presence of Copper NPs in distilled water, respectively, with nanostructure in the shape of a spherical construction and size of about 50 nm were measured using Transmission Electron Microscopy (TEM). The absorption spectrum and Surface Plasmon Resonance (SPR) were measured to study the optical properties of the prepared copper nucleus, and the results showed that the SPR and high optical density were found in the 320 wavelengths at the laser energy of (600 mJ), present at wavelength 333 to the laser energy (700 mJ) and shifted to a lower wavelength (blue shift) with a higher optical density, a wavelength of 341 at the laser energy of (800 mJ).