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In the current study, combinatorial therapeutic approaches to DNA/RNA of human cancer cells and Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsalicylic Acid (ASA) (Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine nanocapsules with surface conjugated DNA/RNA of human cancer cells to targeted Nano drugs for enhanced anti-cancer efficacy and targeted cancer therapy using Nano drugs delivery systems were investigated.

Most patients with anterolateral ankle pain report some history of trauma as the precipitating event. In the majority of cases of anterolateral ankle pain with no history of trauma the cause is proliferative synovitis, especially in the area of the anteroinferior tibiofibular ligament [1,2]. Our case report is about a patient with anterolateral ankle pain and snapping, with no history of trauma, caused by an abnormal peroneal tertius muscle belly. We have found only one similar case reported in the literature [3]. That particular case was treated with arthroscopic resection, which requires specialist arthroscopic skills. In our case we have done an open resection, which can be safely performed by most surgeons.

This review underscores the transformative impact of Computer-Aided Engineering (CAE) on modern engineering, emphasizing its role in advancing sustainable and efficient technological solutions. The CAE industry is further analyzed, focusing on market trends and future directions. The CAE market is projected to grow significantly in the next five years in industries like automotive, aerospace, and energy, especially with the rapid advancements in High-Performance Computing (HPC), Artificial Intelligence (AI), Internet of Things (IoT), and Digital Twin technologies that enhance real-time optimization and predictive capabilities, thus fostering innovation in sustainable product design and performance. Lastly, this review presents KYAMOS Software and its state-of-the-art CAE solutions for tackling high-demand engineering problems, mainly concerning green technologies.

Background: With the development of sports science and badminton equipment, the roles of badminton shoes, such as to alter lower - extremity biomechanical parameters, prevent sports injuries and enhance performance, were confirmed by a mass of studies. Methods: In this study, a serial of methods including literature review, visualization analysis, mathematical statistics, are used to describe the progresses of the badminton shoes relate to exercise in some training aspects, which can be searched by CNKI and SCOPUS databases. Results: Among the exiting research, most mainly focused on evaluation and design of badminton shoes, sports injuries and performance, some have tested and verified the roles mechanism of badminton shoes. However, there are still some disadvantages to can’t ignore, such as the quantities of studies the designed level and the mechanism exploration. Conclusions: To sum up, the roles of the badminton shoes in sports training still need to be explored and confirmed.

The purpose of the present study was to experimentally assess the effect of cognitive strategies of association and dissociation while running on central nervous activation. A total of 30 long distance runners volunteered for the study. The study protocol consisted on three sessions (scheduled in three different days): (1) maximal incremental treadmill test, (2) associative task session, and (3) dissociative task session. The order of sessions 2 and 3 was counterbalanced. During sessions 2 and 3, participants performed a 55 min treadmill run at moderate intensity. Both, associative and dissociative tasks responses were monitoring and recording in real time through dynamic measure tools. Consequently, was possible to have an objective control of the attentional. Results showed a positive session (exercise+attentional task) effect for central nervous activation. The benefits of aerobic exercise at moderate intensity for the performance of self-regulation cognitive tasks are highlighted. The used methodology is proposed as a valid and dynamic option to study cognitions while running in order to overcome the retrospective approach.

Indigenous food processing and preservation methods are on the verge of collapse, yet they proved promising and sustainable. The study assessed the indigenous methods of shea butter processing among rural women in the Borgu Local Government Area of Niger State, Nigeria. Specifically, it described the socioeconomic characteristics of respondents, examined the shea butter processing techniques used and identified the information sources of shea butter processors in the study area. A multistage sampling technique was used to select 100 respondents. Descriptive (such as frequency count, percentage, charts and tables) and inferential statistics (such as Pearson correlation and chi-square) were used to analyze the data. Findings showed the mean age of respondents was 45.61 ± 11.82, with mean years of experience of 20.39 ± 12.96, the majority (85%) were married and the major sources of information on indigenous shea butter processing came from family members and friends. At p ≤ 0.01 there was a significant association between respondents’ usage of indigenous methods and their marital status (ᵡ2 = 84.24; p ≤ 0.01), membership in cooperative society (ᵡ2 = 40.43; p ≤ 0.01), and community membership (ᵡ2 = 53.21; p ≤ 0.01). However, there was a significant relationship between respondents’ usage of indigenous methods and household size (b = 0.290; p ≤ 0.05), quantity produced (b = 0.616; p ≤ 0.10) and annual income (b = -0.765; p ≤ 0.05). It was concluded that indigenous methods of processing shea butter are widespread among respondents; knowledge is acquired through family and friends. Among others, the study recommends that extension agents be posted to rural areas to educate rural women and build on their indigenous knowledge of processing shea butter to introduce high-quality butter.

Background: Epidemiological studies report that females experience greater rates of concussion when compared with males. Biomechanical factors may result in greater post-impact head velocities and accelerations for a given force for females when compared with males. Purpose: To quantify the magnitude, frequency, duration and distribution of impacts to the head and body in rugby league match activities for females versus males. Design: Prospective descriptive epidemiological study. Methods: 21 female and 35 male amateur rugby league players wore wireless impact measuring devices (X2Biosystems; xPatch) behind their right ear over the mastoid process during match participation across a single season. All impact data were collected and downloaded for further analysis. Results: Male amateur rugby league players experienced more head impacts than female amateur rugby league players (470 ±208 vs. 184 ±18; t(12)=-3.7; p=0.0028; d=1.94) per-match over the duration of the study. Male amateur rugby league players recorded a higher median resultant Peak Linear Acceleration (PLA(g)) (15.4 vs. 14.6 g; F(824,834)=51.6; p<0.0001; t(1658)=-3.3; p=0.0012; d=0.10) but a lower median resultant Peak Rotational Acceleration (PRA(rad/s2) (2,802.3 vs. 2,886.3 rad/s2; F(831,827)=3.1; p<0.0001; t(1658)=5.7; p<0.0001; d=0.13) when compared with female amateur rugby league players Conclusion: Females recorded lower median values for PLA(g) and Head Impact Telemetry severity profile (HITSP) for all positional groups but had a higher PRA(rad/s2) for Hit-up Forwards (HUF) and Outside Backs (OSB’s) when compared with male HUF and OSB’s. Females also recorded more impacts to the side of the head (48% vs. 42%) and had a higher 95th percentile resultant PRA(rad/s2) (12,015 vs. 9,523 rad/s2) to the top of the head when compared with male rugby league players.

Numerous studies relate differences in microbial communities to humans. The microbiome is fundamental for the human turn of events, invulnerability, and nourishment. The ordinary microbiota has explicit capability in supplement digestion, xenobiotic and drug digestion, upkeep of underlying trustworthiness of the stomach mucosal boundary, immunomodulation, and assurance against microorganisms. Out of nowhere, it assumes a significant part in criminology. In a few criminal examinations, such perceptible changes in the microbiome and mycobiome can decide the reason or the genuine spot of death. The microbial follows found at the crime location can likewise give obvious proof of responsibility. The point of this audit was to study the microbiome and its applications in scientific sciences and to decide the primary lines of examination that are emerging, as well as its potential commitments to the scientific field.’

The liaison of birth weight to neonatal and mature vigor is especially given important if have the acquaintance of factors distressing in birth weight. Unbiased Best linear prediction of breeding values was estimated from pedigree birth weight records of 13715 Kajli sheep of livestock Experiment Station Khizerabad born 1994 to 2010, and Livestock Experimental Station, Khushab. Data records were statistically analyzed by means of using computer programmed Mixed Model Harvey’s Least Squares and Maximum Likelihood. An animal model was used for heritability estimation following Maximum Likelihood procedure. Estimates of birth weight heritability in Kajli sheep were 0.05 ± 0.019. The estimated breeding values of both forms for males, females, and sire were calculated with significant variation. Both farms data were analyzed by using an animal model program. The squares mean slightest for weight at birth (kg), remained 4.13 ± 0.01 kg. In addition, birth of the year, the birth of type, flock and sex significantly affects the (p < 0.001) trait of birth weight. The domino effect of the current study has rational implications not only for sheep husbandry nevertheless as well as for amplified acquaintance of parameters which drastically persuade deviation of weight in birth as weight in birth has become itself noteworthy forecaster of anon fitness outcomes. These results showed the decreasing genetic and static phenotypic at birth weight. It is likely that there are complex interactions between genetics and environmental factors of parental, placental and fetal origin. Birth weight is highly influenced trait by maternal nutrition, genes, care, management, climate, seasonal variation and type of birth.

Mass serological screening in the Armed Forces involves detecting serological markers of chronic infections, particularly viral hepatitis B and C, syphilis, and HIV among young militaryrecruits. The objective of this study is to evaluate the analytical performance of the chemiluminescence technique (CMIA-Architect i2000 SR) in mass serological screening using the serum-pooling method at the virology laboratory of the Mohammed V Military Teaching Hospital.Samples with known serological results (positive/negative) were grouped into pools of different sizes (2, 5, 10, and 15 sera). These pools were tested using chemiluminescence (CMIA-Architect i2000 SR). A cost analysis was conducted to assess potential savings based on seroprevalence and pool size.Results showed that the pooling method maintained 100% specificity. Overall sensitivities for detecting positive samples were 93.1% for HBV, 83.33% for HCV, and 86.36% for HIV. Positive and negative predictive values were high for all three viral markers, highlighting the reliability of the pooling method. Additionally, this approach generated significant cost savings, ranging from 46% to 80%. Conclusion: This study demonstrated the solid analytical performance of the chemiluminescence technique (CMIA-Architect i 2000 SR) using the serum-pooling method for detecting HBV, HCV, and HIV serological markers in low-seroprevalence regions.