Multi-factorial Depressive Disorders Need Multi-dimensional Interventions
Published on: 4th May, 2017
OCLC Number/Unique Identifier: 7317596898
Depressive disorders are so frequent and disabling health conditions which have been inarguably accepted to be a public health concern [1]. Many drugs have been developed to treat depression, however the efficacy of the antidepressants are inadequate particularly for mild or moderate depression [2-4]. It is also mentioned that when considering the trials about the treatment effect of the antidepressants, you should be careful about the results because of reflecting a small proportion of the society [4]. Despite the methodological issues related to the controversial results about the antidepressant efficacy, a recent review showed that the antidepressant effects of the drugs persist in a six month period [5,6].
Free Radicals, Antioxidants and Redox Potential
Published on: 29th May, 2025
The role of free radicals and antioxidants is often underestimated despite their involvement in key metabolic processes, although they participate in many important metabolic processes in the life of humans, animals and plants. Their quantity and quality differ from each other, which is not respected. Each cell is attacked approximately 10,000 times by free radicals. Oxidative stress is the cause of many problems, especially in viral diseases. Monitoring of redox potentials in body fluids is usually not carried out. Viral replication is influenced by oxidative energy, derived from either host metabolism or free radical activity, which is supplied by oxidation by free radicals or the host. Nucleic acid mutations due to the effect of free radicals can be the cause of carcinomas, and possible defense against mutations could help eradicate dangerous viruses. The importance of malondialdehyde and antibodies against it is discussed. Eliminating free radicals, reducing lipoperoxidation, and protecting against environmental oxidative stress are important factors for human health.Study objective: To highlight the importance of free radicals, antioxidants and redox potentials for patient diagnosis and therapy.Methods: This study synthesizes findings from multiple published sources, including our own research.Results: Findings highlight the role of free radicals in oxidative stress, DNA damage, and viral replication, with redox potential (ORP) and Malondialdehyde (MDA) identified as key diagnostic markers.Conclusion: Monitoring oxidative balance and targeting free radical activity are essential for preventing cellular damage and improving clinical outcomes in oxidative stress-related diseases.
Cannabinoids, Oxidative Stress and Female Reproduction: Where do we stand?
Published on: 6th June, 2025
Cannabis sativum has long been used globally for hallucination. However, detrimental effects on female reproduction have never been studied. The aim of the present paper is to evaluate cannabinoid-induced oxidative stress and reproductive containment in female mice. Fifteen adult female Parkes strain mice were randomly chosen from institutional animal houses (n = 5/group) with ad libitum access to water and food. Animals were grouped into control (vehicle-treated), treated with 6mg of cannabis/100 g of body weight, and 12 mg of cannabis/100 g of body weight. After 15 days all animals were sacrificed and tissues were collected for histology, immunohistochemistry, and estimations of different parameters. Histology and immunohistochemistry (of Cannabinoid Receptor 1; CB1) were performed following standardized protocols. All parameters were estimated either by standard biochemical protocols or by kit following the manufacturer’s protocol. Stress parameters (Super Oxide Dismutase; SOD, Catalase, CAT; Malonaldehyde, MDA and Glutathione Peroxidase; GPx), apoptotic parameters of thecal cells (by Caspase-3 assay), serum level of Estrogen (E2), steroidogenic parameters (3β Hydroxy-steroid dehydrogenase; 3β HSD and 17β Hydroxy-steroid dehydrogenase; 17β HSD) and expression of CB1 were noted in ovary. Data were analyzed by One-way Analysis of Variance (One-way ANOVA) followed by Duncan’s Multiple Range post hoc Test. We found a significant (p < 0.05) decrease in steroidogenic parameters and a significant increase (p < 0.05)in free radical and apoptotic parameters and CB1 receptor expressions upon dose-dependent cannabis treatment. We may conclude that chronic treatment of cannabis causes reproductive containment in females which has never been addressed previously.
Intravenous Leiomyomatosis of the Uterus with Intracardiac Extension
Published on: 22nd July, 2025
Background: Intravascular Leiomyomatosis (IVL) is an often misdiagnosed rare benign mesenchymal tumor characterized by the presence of vascular extension and invasion of smooth muscle cells in a serpiginous-like pattern, first originating in uterine smooth muscle cells. Its growth pattern can involve both ovarian veins, the inferior vena cava, and even reach the right atrium/ventricle in 45% of the cases. The incidence has been reported to be 0.25 to 0.40% of patients with uterine leiomyoma, with about 300 cases reported in the literature. Also, since the tumor is hormone-dependent, most affected individuals are premenopausal women in middle age. Optimal treatment for IVL is complete surgical removal with hysterectomy and oophorectomy, independent of stage. The most frequent perioperative complications are hemorrhage due to tumoral hypervascularization, embolism, and the usual laparotomy complications. We present the case of a 51-year-old female with IVL stage 3 with complete single-stage surgical resolution.
A Prospective Study to Determine Any Correlation between Unnatural Death, Life Line, and Hand Anthropometry
Published on: 11th August, 2025
A study of palm lines, various landmarks on the hand, and their correlation with the hand's anthropometric dimensions may sometimes help predict various future events in the life of an individual. We try to find out any correlation between these appearances and the sudden death of an individual. In the present study, we collected data from an individual’s hand after carefully breaking the rigor mortis in the deceased brought for medicolegal postmortem examination and measured the different dimensions. The data were then subjected to statistical analysis. The article may help rule out the cultural belief about the study of the lifeline and age at the time of death. Palmistry is a self-interpretation of changes in or around the lifeline by an individual, and it varies from person to person. There is no concrete literature proof available that suggests its importance in ascertaining the age of the individual.We also observed that there is no close relation between the age interpreted by the lifeline and the biological age of the individual. Our study shows that the individual either lives too long or too short compared to age by the lifeline.We observed that unnatural deaths are more common in young individuals, and males outnumber females. According to the cause of death, hanging, accident, and poisoning are the most common, followed by sudden death and homicide. In our study, we observed that there is no correlation between unnatural death and the lifeline of an individual and age at the time of death.
Mesh-reinforced Anterior Component Separation for Repair of Large Ventral Hernia: Ten-year Experience in Multiple Centers
Published on: 12th August, 2025
Background: Repair of a large ventral hernia is a challenge for surgeons. Component Separation Technique (CST) is a novel technique for closure of the midline with live tissues without undue tension. This can further be reinforced by a prosthesis. We wanted to see the outcome of mesh-reinforced open Anterior Component Separation (ACS) for large complex ventral hernia repair. We aimed to see the duration of surgery, hospital stay, Surgical Site Occurrence (SSO), and recurrence within the first year after surgery.Materials and methods: We analyzed data of patients operated from January 2014 to January 2024 for a period of 10 years in three centers. There were 13 patients with divarication of recti without any previous surgery. Rest 44 patients had either incisional hernia or port site hernia. All patients had defect sizes more than 8 cm. Open bilateral anterior component separations were done to achieve midline closure. Medium-pore soft Prolene mesh was used to reinforce the midline closure by an on-lay technique. Patients were followed up to 1 year after surgery to assess efficacy and complications of the procedure.Results: The average operating time was 73 ± 12 min. Hospital stay was 3 to 7 days, mean was 5.3 days. Surgical site occurrence was 14%. These include seroma formation, major wound infection, and abscess formation. There was no flap necrosis nor mesh removal. There was no recurrence within one year of follow-up after surgery. Conclusion: Open mesh Anterior Component Separation (mACS) is an easy and effective way of treating large and complex ventral hernia. Operating time is substantially less than posterior component separation. Reinforcement with mesh reduces recurrence.
Lifestyle Diseases and the Hair Growth Cycle: A multidisciplinary approach using Nourkrin® with Marilex®, a proteoglycan replacement therapy, for anagen induction and maintenance
Published on: 8th December, 2017
OCLC Number/Unique Identifier: 7317598559
Multiple studies have investigated the relationship between androgenetic alopecia and cardiovascular disease, including studies that have identified elevated rates of cardiovascular disease in patients with vertex hair loss, vertex and frontal hair loss, early onset hair loss and rapidly progressive hair loss. In addition, increased risks for hypertension, excess weight, abnormal lipids, insulin resistance, carotid atheromatosis and death from diabetes or heart disease have been reported in this population. Studies investigating an association between androgenetic alopecia and metabolic syndrome have yielded conflicting findings. Distinct guidelines for the detection and prevention of cardiovascular disease in individuals with androgenetic alopecia have not been established. In addition to the traditional risk factors for developing cardiovascular disease, included in the definition of the metabolic syndrome, several skin diseases have recently been shown to be markers of conditions relating to the patient’s overall health. Physicians should be aware of the possible connection between relatively frequent skin diseases, such as psoriasis and hair growth disruptions, including androgenetic alopecia and female pattern hair loss and cardiovascular disease. This review is concentrated on the association between insulin resistance, type 2 diabetes, abdominal fat, cardiovascular disease and hair growth disruptions as an early indicator of these underlying conditions. We have investigated the importance of robust primary clinical treatment measures to address the manifestation of hair loss due to a disruption caused by metabolic syndrome as an effective means to alleviate further stress induced hair loss, which can exacerbate the underlying cause.
Forest History Association of Wisconsin
Published on: 30th October, 2024
The Enterprise Radiation Forest (ERF) study was initially introduced as a topic of discussion at the Institute of Forest Genetics, USDA, USFS, in the late 1960s. During that period, a program was endorsed for investigating the impacts of radiation on the forest ecosystem. The rationale for this was to facilitate the prediction of potential outcomes in the occurrence of a nuclear disaster. The research location was situated within the forested lands in Enterprise of Oneida County, Wisconsin, United States. The radiation source in question was a 10,000 curie source of Cesium-137, characterized by a halflife of 33 years. Furthermore, a study concerning lichens was also carried out, the data, photographs, and micrographs were meticulously gathered to illustrate the pre-irradiation activity of the species. This subject holds significant value for dissemination among peers in the scientific community, particularly considering the resilience exhibited by natural ecosystems in response to varying levels of radiation. The information is reviewed with the objective of the entire program to ascertain the potential consequences for a northern forest ecosystem in the event of a nuclear disaster, in addition to the two publications from the Atomic Energy Commission.
Effect of storage period on the quality characteristics of two varieties of African Mango Seed Flour at ambient temperature
Published on: 10th August, 2017
OCLC Number/Unique Identifier: 7286354684
The effects of storage of Ogbona seed flour (Irivingia gabonensis and Irivingia excelsa), at ambient condition (30±20C, 65-74% RH) for 0-4 months on some physical characteristics were investigated. The samples were subjected to storage in air tight polyethylene bags for up to four months. Samples were removed at intervals of 0, 1, 2, 3 and 4 months for analysis. The chemical: proximate constituents, free-fatty acids and peroxide values; selected functional properties: water/oil absorption capacity, foam capacity and viscosity and sensory attributes of the samples were investigated. The result shows that there was no observable change in the chemical composition, selected functional and sensory properties of the two varieties of Ogbona seed flours when stored up to two months but decreased from third to fourth month during storage at ambient temperature. Therefore, storage at ambient temperature (30±20C, 65-74% RH) could extend the shelf life of the samples for up to two months in air-tight polyethylene bags of 0.7mm thickness without losing its quality characteristics.
Nitrogen supply effect on lettuce response to Botrytis cinerea and Sclerotinia minor
Published on: 6th November, 2023
Background information: Cultural practices play an important role on the development of pathogens (Datnoff, et al. 2007). In this context, several authors have been interested in studying the effects of mineral nutrition on the resistance of vegetables and fruits to fungi during storage, especially nitrogen.The purpose of the study: In this work we tested the effects of three contrasted regimes of nitrogen supply, with nitrate concentrations in the nutrient solutions of 2 mM (low), 10 mM (normal) and 20 mM (high) on the susceptibility of Lactuca sativa L towards Botrytis cinerea (BC87) and Sclerotinia minor (SM) during storage.Once harvested, the outerleaves of the plants derived from the three nitrogen regimes were inoculated with either Botrytis cinerea (BC87) or Sclerotinia minor (SM). Data showed that the resistance to this two pathogens increase when plants were developed under low nitrogen concentration. This resistance observed is correlated with low values in oxidative stress indicators (MDA and H2O2) and high values in total phenols.
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