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Radical cystectomy with urinary diversion is the standard treatment for muscle-invasive bladder cancer. The impact of the type of urinary diversion on quality of life (QoL) remains debated. This cross-sectional study assessed QoL in 57 patients who underwent radical cystectomy between 2014 and 2022 at two urology departments in Rabat, Morocco, using the Bladder Cancer Index (BCI), the SF-36, and the Body Image Scale (BIS). Multiple linear regression identified socioeconomic status, body image perception, urinary discomfort, and comorbidities as the main determinants of QoL, with the type of urinary diversion playing an indirect role mediated through these factors. These findings underscore the need for a multidimensional approach when evaluating and optimizing QoL outcomes after radical cystectomy.

Ureteral double-J stents are a commonly used device in urological practice to allow urinary drainage, avoid ureteral obstruction processes, and protect the upper urinary tract after surgical procedures. However, long indwelling time may give rise to numerous complications, such as infection, migration, and fragmentation of the stent, especially encrustation. Encrustation of stents is a well-known complication that has been closely related to the time active of the stent and can cause significant morbidity if not timely addressed. In severe cases, abundant mineral deposition can result in the development of large calculi encasing the stent and rarely progress to staghorn stones. These cases may pose challenges in terms of the extraction of the stent and may result in complex endourological intervention. The encrustation likelihood is substantially higher if stents are left forgotten or remain in place longer than the advised period. Most patients with heavily encrusted stents have symptoms including flank pain, urinary tract infection, hematuria, or obstructive uropathy, but can present without any symptoms, and this can delay the diagnosis.

Background: Malaria and typhoid fever remain major public health problems and important causes of febrile illness in sub-Saharan Africa, particularly in urban settings characterized by poor sanitation, unsafe water supply, overcrowding, and persistent malaria transmission. The clinical manifestations of both diseases frequently overlap, making accurate diagnosis difficult and often leading to empirical treatment, inappropriate antimicrobial use, and delayed patient management. This study assessed the occurrence, associated risk factors, and clinical implications of malaria–typhoid co-infection among febrile patients attending the Camrail Medical Center in Douala, Cameroon. Methods: A hospital-based analytical cross-sectional study was conducted among 220 febrile patients recruited systematically at the outpatient department. Data were collected using structured questionnaires, clinical assessment forms, and laboratory investigations. Malaria infection was diagnosed using standard parasitological methods, while typhoid fever was assessed using routine laboratory procedures. Data were analyzed using descriptive statistics, chi-square tests, and multivariate logistic regression in SPSS version 25. Results: Malaria mono-infection accounted for 31.8% of cases, typhoid mono-infection for 10.9%, and malaria–typhoid co-infection for 15.5%, whereas 41.8% of participants had neither infection. Significant predictors of co-infection included unsafe water sources (AOR = 3.12; p = 0.001), poor food hygiene (AOR = 3.85; p < 0.001), non-use of bed nets (AOR = 2.21; p = 0.021), and exposure to stagnant water (AOR = 2.76; p = 0.004). Co-infected patients experienced significantly more severe clinical manifestations, including high fever, vomiting, diarrhea, abdominal pain, and headache. Age-stratified analysis showed a higher proportion of co-infection among participants aged ≤25 years (18.8%) compared with those aged ≥26 years (12.9%), although the difference was not statistically significant (p = 0.194). Gender-based analysis demonstrated no significant association between sex and infection category (p = 0.606).Conclusion and recommendations: Malaria–typhoid co-infection remains a significant public health concern in Douala. Integrated diagnostic approaches, improved environmental sanitation, safe water access, food hygiene promotion, and strengthened malaria prevention measures are essential to reducing the burden of co-infection and limiting inappropriate antimicrobial use.

Monoclonal gammopathy of undetermined significance (MGUS) may be associated with peripheral neuropathy; however, IgG MGUS–associated chronic inflammatory demyelinating polyneuropathy (CIDP) is uncommon and generally follows a slowly progressive or relapsing course. We report a man in his early 40s who developed rapidly progressive sensorimotor weakness resulting in quadriparesis and inability to ambulate within eight weeks. Examination demonstrated severe proximal and distal weakness, glove-and-stocking sensory loss, and absent reflexes. Cerebrospinal fluid protein was markedly elevated, and nerve conduction studies/electromyography demonstrated acquired demyelination with secondary axonal loss. Evaluation identified IgG MGUS, supporting the diagnosis of MGUS-associated CIDP after alternative etiologies were excluded. Intravenous immunoglobulin was discontinued on day 3 following the development of a pulmonary embolism. The patient subsequently completed eight plasma-exchange sessions, with improvement in lower-extremity strength to 3/5, upper-extremity strength to 4/5, and sensory symptoms. He was discharged to rehabilitation with planned monthly plasma exchange.recognised clinical spectrum of IgG MGUS–associated CIDP and demonstrates that meaningful neurological improvement may occur with plasma exchange despite rapid progression and severe initial disability.

Introduction: Few studies have explored the vulnerability of women with polycystic ovary syndrome (PCOS) to developing cervical cancer and its precursor lesions. Objective: To describe the clinical, metabolic, and endocrine characteristics of a series of women with cervical squamous intraepithelial lesions and polycystic ovary syndrome, aiming to generate hypotheses regarding the potential pathophysiological mechanisms linking both conditions.Methods: A descriptive and hypothesis-generating study was conducted. The series consisted of nine women with a cytological diagnosis of cervical squamous intraepithelial lesions (SIL) who also met the Rotterdam criteria for PCOS. Characterization included age, sexual behavior, toxic habits, history of hypertension and diabetes mellitus, body mass index (BMI) and waist-to-hip ratio (WHR), metabolic parameters (insulin resistance, dyslipidemia), serum hormone levels (testosterone, prolactin, estradiol), human papillomavirus (HPV) 16/18 infection, grade of the lesion, and PCOS phenotypes. Results: The mean age was 37,11 ± 12,8 years. Abdominal obesity was detected in 55,5% and insulin resistance in 44,4% of cases. Hyperprolactinemia was present in 33,3%. HPV 16/18 infection was identified in 77,7% of cases. Most patients presented high-grade squamous intraepithelial lesions (HSIL) and PCOS phenotype D. Conclusion: The presence of HSIL in more than a third of the women in this case series is compatible with the hypothesis that PCOS, particularly those with insulin resistance, abdominal obesity, or hyperprolactinemia, may act as a multifactorial risk factor for cervical lesions, either independently or synergistically through metabolic and hormonal pathways that interact with HPV. These findings should be interpreted as preliminary observations that warrant confirmation in larger, controlled studies.

Introduction: In the Republic of Congo, Mombénzélé village’s an area endemic for cholera where environmental and socio-economic factors favor the persistence of the epidemic. This study assessed the knowledge, attitudes, and practices (KAP) of the indigenous peoples of Mombénzélé regarding cholera to design culturally appropriate and sustainable prevention strategies.Materials and methods: This was a preliminary cross-sectional pilot study, descriptive and analytical in nature, conducted from April 21 to 31, 2026, in the indigenous community of Mombénzélé (Impfondo district, Republic of Congo). The study assessed adults. Convenience sampling was used. Data were collected via a questionnaire in Lingala and face-to-face interviews, with secure data entry on tablets. Analysis using SPSS, including socio-demographic profiles, KAP variables, and chi-square tests (p < 0.05), was conducted in strict compliance with ethical principles and anonymization guidelines. Results: The population studied is predominantly male (60%) and without formal education (92%). Cholera is largely unknown to 92% of individuals, who believe exclusively in mystical causes. Hygiene practices are dangerous, with a complete lack of water treatment (100%) and systematic recourse to traditional healers (60%). Vulnerability is exacerbated by open defecation (56% in the river) and a refusal to use chlorinated water (88%). Sociodemographic factors significantly influence behaviors, notably age, which impacts funeral practices (p = 0.033), and educational level, which determines access to the river (p = 0.0033). The main activity influences the consumption of treated water (p = 0.0218) and determines (p = 0.000026) funeral practices. Household size impacts the perception of cholera lethality (p = 0.009) and guides the choice of funeral practices (p = 0.045).Discussion: A cholera epidemic has struck the Mombénzélé village, affecting 96% of adults and exacerbated by a complete lack of awareness of the symptoms and a rejection of chlorinated water. The health crisis has driven 76% of the population to traditional medicine. Conclusion: To contain the health crisis in Mombénzélé, it’s essential to deploy a strategy combining the training of bilingual mediators and the improvement of water infrastructure, in order to overcome the lack of information on the transmission of cholera and to adapt prevention to the realities and cultural barriers of the indigenous community.

While canine pets offer significant psychological and physical benefits to their owners, especially children, there are well-documented health risks associated with pathogens that can be transmitted to humans.To determine the prevalence of intestinal parasites, with an emphasis on zoonotic ones, in children and their dogs, and to identify risk factors associated with infection, a cross-sectional descriptive study was conducted in children from primary schools in the Cerro municipality, province of Havana. One hundred and three children (36 with dogs and 67 without pets) from fifth and sixth grades were selected. Three stool samples were collected on alternate days, and one stool sample was collected from their pets using conventional coproparasitological techniques between September and December 2023. The results showed a prevalence of 38.8% of intestinal parasites in the children studied. Blastocystis spp. (30.1%) and Giardia duodenalis (17.5%) were the most prevalent zoonotic species. Ancylostoma caninum (8.3%) was the most frequent zoonotic parasite in dogs. Male sex was the only variable that showed statistical significance, associated with a higher risk of infection. There were no significant differences in the prevalence of intestinal parasites in the group of children with dogs compared to those without pets, and no statistical association in the analyzed epidemiological variablesIt is important to develop a One Health approach for the control of these zoonoses, as dogs can act as important sentinels of public health.