An unusual case of a maxillary sinonasal neuroendocrine carcinoma
Published on: 18th February, 2020
OCLC Number/Unique Identifier: 8550965615
It’s a 24 years old female patient who presented with rhinological burning pain evolving since 1 year. She didn’t consult until a blistering lesion filled half of the oral cavity. The initial biopsy of the tumor was interpreted as a round cell tumor process.
Opera-glass hand with arthritis mutilans in psoriatic arthritis
Published on: 28th May, 2020
OCLC Number/Unique Identifier: 8605993421
A 42 years old gentleman who was a known case of Psoriasis vulgaris since last 5 years presented to the Rheumatology clinic with inflammatory arthritis predominantly involving the joints of the upper extremities. Musculoskeletal examination of both hands revealed dactylitis and distal interphalangeal joint arthritis. He had a shortened right ring finger with excessive transverse skin folding suggestive of an Opera-Glass hand
Syphilitic pemphigus
Published on: 22nd October, 2020
OCLC Number/Unique Identifier: 8691703922
A 34-week premature newborn, child of a mother without prenatal controls, a marijuana user, with gestational syphilis with a positive rapid plasma reagin test (RPR) titer 1:16, did not receive treatment during pregnancy. The newborn presented congenital syphilis, RPR titer 1: 256 positive test.
Laparoscopic duodenal switch
Published on: 9th March, 2022
Laparoscopic biliopancreatic diversion with duodenal switch (BPD-DS) is a technically challenging operation that requires extensive surgical dissection, transection and restoration of intestinal continuity, and advanced laparoscopic suturing skills.
Measurement of background ionizing radiation in the federal university of technology owerri, Nigeria using calibrated digital geiger counter
Published on: 25th May, 2020
OCLC Number/Unique Identifier: 8621042354
The measurement of the natural ionizing radiation in the Federal University of Technology Owerri, Nigeria was carried out using a well calibrated Digital Geiger Muller counter models GCA – 04w. Measurements were taken randomly in thirty (30) diff erent locations outside the building and thirty (30) locations inside diff erent buildings in the University. Results obtained for outdoor Dose rate ranges from 0.07 μSv/hr to 0.23 μSv/hr with a mean value of 0.144 μSv/hr. While the result for the indoor dose rate ranges from 0.08 μSv/hr to 0.21 μSv/hr with a mean of 0.14 μSv/hr. The highest value recorded for the outdoor radiation is from the university front gate which is .023μSv/hr. While the highest value recorded inside the buildings is from the School of Agriculture and Agricultural Technology (SAAT) which is 0.21 μSv/hr. All these values are lower than the world safely limits of 0.247 μSv/hr. This shows that the risk of ionizing radiation on the staff and students of the Federal University of Technology is minimal.
Metabolic Syndrome, Cardiovascular Disease and the Hair Growth Cycle: Addressing hair growth disruptions using Nourkrin® with Marilex® as a proteoglycan replacement therapy: A concise review
Published on: 23rd May, 2018
OCLC Number/Unique Identifier: 7671837063
Alopecia is associated with an increased risk of coronary heart disease, and it appears that there is a relationship between the degree of hair loss and the risk of coronary heart disease, meaning, the greater the severity of alopecia, the greater the risk of coronary heart disease. Alopecia is also associated with an increased risk of hypertension, hyperinsulinemia, insulin resistance, metabolic syndrome as well as elevated serum total cholesterol and triglyceride levels. It has not been definitively established whether patients with androgenetic alopecia have a higher cardiovascular risk or prevalence of metabolic syndrome, and results of recent studies indicate that androgenetic alopecia patients do not show differences in insulin resistance or the prevalence of metabolic syndrome. However, androgenetic alopecia patients do show a higher cardiovascular risk, characterised by increased inflammatory parameters and Lp(a) levels. Data collected from female populations are scarce, but it would be interesting to extend our clinical knowledge with this type of data to further our understanding of the connection between androgenetic alopecia, metabolic syndrome and cardiovascular risk. The divergence in results from different studies done in this context may simply be a result of the composition of the study populations with respect to age, gender, severity of alopecia, sample size and perhaps ethnicity. In this connection, a large group of androgenetic alopecia patients is necessary, including different representative groups and varying severities of alopecia. Furthermore, it is recommended that all women and men with androgenetic alopecia be thoroughly examined and that lifestyle changes are made early on to reduce the risk of various problems associated with metabolic syndrome, since androgenetic alopecia can be considered an early marker of metabolic syndrome.
Concise Review: Considerations for the Formulation, Delivery and Administration Routes of Biopharmaceuticals
Published on: 28th June, 2017
OCLC Number/Unique Identifier: 7317597467
The drugs of biological origins have attracted the attention of many pharmaceutical companies where it is essential to protect the heterogeneous nature and the optimal three dimensional structures of the different macromolecules. These molecules are used in both the investigation and therapy purposes, so their maximum activities should be maintained. This requires the designing of certain delivery formulations that suits the macromolecule nature, its target organ, the required dose and delivery route, and that’s why the biotech companies invest millions of dollars towards achieving that. The first main focal point of this article includes the recent developments in the formulation technologies for several biomacromolecule classes. The second focal point concentrates on the current considerations for optimizing their delivery for a maximum performance in the body.
Diabetes and chronic kidney disease: a rare cause for a very common association
Published on: 20th November, 2019
OCLC Number/Unique Identifier: 8404983788
The authors present the case of a 45-year-old female patient with diabetes and chronic kidney disease (CKD). She had unsatisfactory glycemic control, and showed some intellectual limitations. Her urine exam was unremarkable, and her renal ultrasound revealed single right kidney with aspects suggesting ureteropelvic junction syndrome. Her mother had also suffered from diabetes and CKD G5D presenting in the sixth to seventh decade.
An hereditary cause for CKD was considered, which led the authors to investigate an autosomal dominant cause for CKD with a tubulointerstitial phenotype, taking into account the personal and family history for diabetes and also the renal imaging; a large deletion in the HNF-1β gene was identified through Multiplex Ligand Probe Assay (MLPA) analysis, explaining the phenotype.
Genetic causes of CKD should be considered in the presence of positive family history for CKD, and the coexistence of diabetes with bland urine sediment should raise the possibility of a syndromic cause of the phenotype, namely involving HNF-1β gene mutations or deletions.
Causes of hospital admission of chronic kidney disease patient in a tertiary kidney care hospital
Published on: 21st June, 2019
OCLC Number/Unique Identifier: 8172399426
Background: Patients with chronic kidney disease (CKD) are at the risk of increase hospital admission as compared to the general population, due to various reasons. They have increased vulnerability to cardiovascular diseases (CVD) as well as infections, therefore they usually got admit in health care units due to various reasons. The causes of hospitalization in CKD patients in this part of the world are not studied well.
Methods: This cross sectional study was conducted in The Kidney Centre Post Graduate Training Institute (TKC-PGTI) of Karachi. Variables included in the study were age, gender, are of residence, ethnicity, smoking status and level of education. Comorbid conditions like causes of CKD and causes of hospitalization. Data analysis performed by using software IBM SPSS 21.
Results: Total of 269 patients were enrolled in our study. The male 148(55%), mean age was 55 years. The most common cause of hospitalization in our population was infection148 (55%) and urinary tract infection (UTI) was the most common site of infection 55 (20%) followed by sepsis of unknown origin 29(10.8%). Cardiovascular events like volume overload 32 (11.4%) and acute coronary syndrome 20(7.4%) were the second most important cause of hospitalization.
Conclusion: Hospitalization of CKD patients is high, and in our population infection is found to be the leading cause of hospital admission. Infection originating from urinary tract is more common in all stages of CKD patients, while blood born infection originating from double lumen (DL) dialysis catheter or arteriovenous fistula (AVF) cannulation is more common in dialysis population. Cardiovascular events, both acute coronary syndrome and pulmonary edema due to volume overload followed the infections.
Nano-formulations for Ophthalmic Treatments
Published on: 29th December, 2017
OCLC Number/Unique Identifier: 7325061328
Ocular disorders encompass a multitude of diseases that are unique in their cause, therapy and degree of severity. Due to distinctive morphology of the eye, efficient ocular drug delivery has proven to be a difficult task. Current treatments of ophthalmological diseases include the usage of both intrusive as well as nonintrusive methods such as injections, eye drops, ointments, gels etc. The current state of the art drug delivery methods are associated with low bioavailability and therefore nanotechnology based drug delivery approached are evolving as for improving the therapeutic index of currently used drugs against variety of ocular disorders. This review highlights the recent developments in nano-formulations for ophthalmic treatment and also offers discussions towards the future prospectus of nano-formulations in the mainstream of ophthalmic diseases.
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