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Phytoplasmas belong to the parasitic group of mollicutes, which represent a phylogenetically coherent group of pathogens that colonize a wide spectrum of hosts and insects [1].

Introduction: In an earlier study, we described and validated a VKA dose-finding algorithm (B2A), based on a novel bidirectional factor (BF). We designed a prospective study to evaluate the B2A in a daily care setting. Methods: In this open-label prospective study, we compared the outcomes of the B2A over the year 2020 with the outcomes of the previous year (2019), using regular algorithms. The outcomes were the duration of Time in the Therapeutic Range (TTR), the percentage of automated dose proposals (PAuP) and the percentage of accepted dose proposals (PAcP). The data were obtained from three anticoagulation centers in the Netherlands, in four locations. The outcomes of this study were based on a non-inferiority level.Results: The TTR over the year 2020 was at least non-inferior compared with the standard of care treatment. The percentage of automated proposals increased in all centers to approximately 96% of all dosages. Conclusion: The B2A performs non-inferior compared with the existing algorithms and in some aspects even better.

Ono S, Kondo S. Molecular Theory of Surface Tension in Liquids, in Structure of Liquids, series Encyclopedia of Physics, Springer, Berlin, Heidelberg. 1960; 3/10:134-280. Rowlinson JS, Widom B. Molecular Theory of Capillarity, Oxford University Press, Oxford. 1989. Jaycock MJ, Parfitt GD. Chemistry of Interfaces, Halstead Press, John Wiley & Sons, New York. 1981. Adamson AW, Gast AP. Physical Chemistry of Surfaces, Wiley-Interscience Publication, John Wiley & Sons. 1997. Rusanov AI, Prokhorov VA. Interfacial Tensiometry, Elsevier, Amsterdam. 1996. Baranov SA, Dikusar AI. Kinetics of Electrochemical Nanonucleation upon Induced Codeposition of Iron-Group Metals with Refractory Metals (W, Mo, Re). Surface Engineering and Applied Electrochemistry. 2022; 589(5):429-439. DOI: 3103/S1068375522050027. Baranov SA. Surface energy for nanowire. Annals of Mathematics and Physics. 2022; 81-86. DOI: 10.17352/amp.000043. Baranov SA. Surface Energy, and Production Micro-and Nanowire. Journal of Nanosciences Research & Reports 2022; 4(4):1-4. DOI: doi.org/10.47363/JNSRR/2022(4)142. Baranov SA, Rekhviashvili SSh, Sokurov AA. Some problems of simulation of the thermodynamic properties of droplets. Surface Engineering and Applied Electrochemistry. 2019; 55(3):286-193. DOI: 5281/zenodo.1228887. Sears GW. A grown mechanism for mercury whiskers. Acta metallurgical. 1955; 3(4):367-369. Cahn RW. Background to rapid solidification processing. Liebermann HH. (ed.) Rapidly Solidified Alloys, Materials Engineering Series. Dekker, Parsippany, NJ. 1993; 3:1-15. Khachaturyan AG. Theory of structural transformations in solids, Dover Publications, New York. 2008.

Fox, et al. [1] reported on the relevant cardiopulmonary findings in a series of autopsies of patients deceased from SARS-CoV-2 infection. In particular, regarding the histologic examination of the lungs, they observed bilateral diffuse alveolar damage with a lymphocytic infiltrate, thickened alveolar capillaries, fibrin thrombi within the capillaries and small vessels, and entrapment of neutrophils, without any significant neutrophilic, infiltrate within airways or the interstitium. 

The last four decades have been particularly marked by devastating diseases. During this period, humanity hasexperienced plagues such as SARS, bird Flu, Ebola, Chikun-gunya, COVID-19 in addition to diseases that were already decimating populations.

The problems of guaranteeing the best possible social and health services in every part of the world to combat any form of disability and limitation of participation for all, as indicated by international ethical-political documents, are still very great. A critical point that could favour this progress is to enhance the integration between the growing potential of rehabilitation science (medical and clinical evidence, technologies, and training of numerous operators..) and the ability of communities as a whole to stimulate, support and qualify these interventions with the participation of citizens (families, neighbours and associations) who can voluntarily actively carry out important synergistic actions in many fields. This could develop in any socio-economic condition; in developed ones supporting and finalizing any treatment in common life and in developing countries offering competencies and knowledge to the strong funding actions of community projects aimed at populations with disabilities in this part of the World. The community of rehabilitation professionals, national governments and rulers, and international institutions (UN, WHO..) must well understand this aspect and make it their own in training, in the definition of care protocols, in the definition of the organization of socio-health and rehabilitation systems in each country in relation to the different local economic and cultural conditions.

Hyperglycemia due to abnormalities in insulin production, insulin action, or both characterizes the metabolic disorders known collectively as diabetes [1]. 

The main focus of this study concentrates on evaluating the quality of groundwater in and around the zone of pattamadai where the production of the mat in this region is a landmark industry, which is using dyes in a larger volume. The primary work starts with the collection of water samples from 13 boreholes and 13 hand-dug wells in different time intervals in the month of March 2021, which is a dry season. As per standards the water quality parameters have been evaluated and observed to be within the range. All the physico-chemical parameters for the samples have been studied for boreholes and hand-dug wells as all the values are observed to be within the range and are highlighted in the results.

Aim: To determine the correlation between mammographic features of breast cancer with molecular subtypes and to calculate the predictive value of these features. Materials and method: This is a retrospective study of breast cancer patients presenting between January 2017 and December 2021, who underwent mammography of the breast followed by true cut biopsy and immunohistochemical staining of the tissue sample. Breast carcinoma patients without preoperative mammograms, those unable to undergo histopathological and IHC examinations and h/o prior cancer treatment were excluded. On mammography, size, shape, margins, density, the presence or absence of suspicious calcifications and associated features were noted. Results: Irregular-shaped tumors with spiculated margins were likely to be luminal A/B subtypes of breast cancer. Tumors with a round or oval shape with circumscribed margins were highly suggestive of Triple negative breast cancer. Tumors with suspicious calcifications were likely to be HER2 enriched. Conclusion: Mammographic features such as irregular or round shape, circumscribed or noncircumscribed margins and suspicious calcifications are strongly correlated in predicting the molecular subtypes of breast cancer and thus may further expand the role of conventional breast imaging.

A 25 years old pregnant woman had a painful labor in her 38th week of pregnancy. Because of a previous delivery by a cesarean section, she underwent a second cesarean section. Her past medical and family history was unimportant. We performed the surgery under spinal anesthesia. The surgery was uneventful and the baby was in a good health. After 9 hours of surgery, she complained of painless swelling in the parotid glands. Physical examination and laboratories were normal. We started rehydration with normal saline and one dose of hydrocortisone (100 mg IV route). Close monitoring showed no problems in swallowing or any purulent discharge. Two days later, we had a complete resolution of the swelling. We discharged the woman with her child with no complaints. Our case is one of the rare cases of anesthesia mumps after spinal anesthesia. Physicians should be careful in considering such rare cases. Early diagnosis and management is the key.