Progress in the development of Lipoplex and Polyplex modified with Anionic Polymer for efficient Gene Delivery
Published on: 24th July, 2017
OCLC Number/Unique Identifier: 7317598455
Nucleic acid-based therapy has become an increasingly important strategy for treating a variety of human diseases. In systemic therapy, a therapeutic gene must be delivered efficiently to its target tissues without side effects. To deliver a therapeutic gene such as plasmid DNA (pDNA) or small interfering RNA (siRNA) to target tissues by systemic administration, cationic carriers such as cationic liposomes and polymers have been commonly used as a non-viral vector. However, the binary complex of therapeutic gene and cationic carrier must be stabilized in the blood circulation by avoiding agglutination with blood components, because electrostatic interactions between positively charged complexes and negatively charged erythrocytes can cause agglutination, and the agglutinates contribute to high entrapment of the therapeutic genes in the highly extended lung capillaries. One promising approach for overcoming this problem is modification of the surface of cationic complexes with anionic biodegradable polymers such as hyaluronic acid, chondroitin sulfate, or polyglutamic acid. As another approach, we recently developed a sequential injection method of anionic polymer and cationic liposome/therapeutic gene complex (cationic lipoplex) for delivery of a therapeutic gene into the liver or liver metastasis. In this review, we describe recent advances in the delivery of therapeutic genes by lipid- and polymer-based carrier systems using anionic polymers.
Trans-abdominal cervical cerclage revisited
Published on: 18th June, 2019
OCLC Number/Unique Identifier: 8165593316
Changes in contemporary obstetric and gynaecological practice in relation to ultrasound cervical screening during pregnancy, the treatment of intra-epithelial cervical neoplasia and laparoscopic surgery have resulted in an increased utilization of trans-abdominal cervico-isthmic cerclage in an attempt to reduce the incidence of mid-trimester and early preterm birth in women with repeated pregnancy loss.
A Gecko-eye View of Naturalistic Enclosures
Published on: 1st December, 2023
Naturalistic enclosures have become a popular exhibition technique for zoos, and reptiles and amphibians are regularly housed in these exhibits. While a considerable sum of research indicates that visitors prefer naturalistic exhibits, there are fewer studies documenting the behaviour and welfare of animals housed under these conditions. This study investigated the impact of a naturalistic enclosure on the behaviour of the turquoise dwarf gecko (Lygodactylus williamsi), and the welfare perceptions of visitors. When kept under naturalistic enclosures, dwarf geckos were seen to bask (p = 0.022), and engage in inactive behaviours (p = 0.001) significantly less frequently. A non-significant decrease was also seen in locomotion | (p = 0.074). While time spent hidden remains a confounding factor for behavioural analysis, the study indicates that when provided with hiding opportunities, L. williamsi may spend a considerable amount of time hidden from the public. Questionnaire analysis revealed that 84.6% of individuals believed that naturalistic enclosures demonstrated better welfare. Additionally, individuals who had previously owned a reptile were more likely to identify that areas to hide, enrich, and mimic the natural environment were important aspects of enclosure design. While the actual benefits of naturalistic enclosure design cannot be fully addressed by this study, this work suggests that visitors tend to inherently believe that naturalistic enclosures facilitate better welfare, even if they are not aware of the natural environment of the species being housed. This requires keepers to consider both aspects of functionality and enclosure relevance when designing exhibits for herptiles.
Cytogenetic and clinical features of longlivers with osteoarthritis from Precarpathian region (West Ukraine) for 1998-2014yy
Published on: 3rd May, 2019
OCLC Number/Unique Identifier: 8212035257
Osteoarthritis is the most common form of arthritis, affecting millions of people worldwide.
Aim of our study was to assess the clinical and the cytogenetic characteristics in longlivers with osteoarthritis from Precarpathian region (Ukraine).
Methods: Cytogenetic, Clinical
Results: All of the subjects were separated into three groups: І group - 146 longlivers patients who had hypertension and osteoarthritis (ОА); II group - 93 longlivers patients only with ОА. The control (third) group included 130 patients aged 90-102 years without osteoarthritis and hypertension in anamnesis. In the age group more than 95 years, men and women of both groups were significant difference (p<0,05) to be compared with control.
Cytogenetic characteristics of the long-livers with on osteoarthritis showed that most there is a tendency for a higher frequency of chromosomal aberrations in male long-livers and tere are significant difference among control (p<0,05). The number of chromosomes associated in a single cell was significantly higher (p<0,05) in both groups compared to control.
Conclusion: The importance of this study resides, to the best of our knowledge, in the fact that the largest group of patients in Ukraine was analyzed and assessed.
Evaluating cortical bone porosity using Hr-Pqct
Published on: 27th August, 2019
OCLC Number/Unique Identifier: 8465497330
This work aims to evaluate cortical porosity through a high-resolution peripheral quantitative micro-tomography in a group of 47 patients. All patients, in vivo, were subjected to the medical care protocol of the University Hospital Clementino Fraga, 020-213. Patients were women aged from 37 to 82 years old, who did not present fractures in their lower and upper limbs, all of them showing good health. During screening, they were required to have normal BMD (as determined by DXA; T-score ≥ 1.0) and no low-trauma fractures history. The exclusion criteria for all the individuals enrolled in this control study include, for example, alcoholism, chronic drug use, and chronic gastrointestinal disease. Male patients ranging from 42 to 79 years old presented the same health issues as women group. Results showed an increase in the amount of pores on the cortical bone of the evaluated patients over time; however, this increase was also observed in pore diameter, as well as a decrease in the border between the cortical and trabecular bone, indicating a deterioration in cortical bone quality over the years.
Osteogenic Accelerated OrthodonticsTM for treatment of a Skeletal Class II patient with moderate crowding
Published on: 18th September, 2017
OCLC Number/Unique Identifier: 7286353388
Introduction: A 17 years old male patient was treated at the University orthodontic department. He had the chief complaint of unaesthetic appearance of his teeth, mostly for anterior crowding. The pretreatment records showed a Class II skeletal relation, moderate upper and lower anterior crowding, 0.5mm of overbite and 2mm of overjet.
Materials and Methods: It was suggested Osteogenic Accelerated Orthodontics (OAOTM), the treatment option was very attractive to the patient although it required a surgical procedure and a more expensive type of treatment.
Results: The overall treatment time was 6 months, facial balance was improved and the final occlusal relationships from the functional and aesthetics perspective were good.
Conclusion: OAOTM is a good alternative to reduce extractions rate as it increases the scope of tooth movement and strengthen the periodontal tissues thru bone grafting, although these claims require more scientific data to be validated.
Alternative treatment methods in eyes with pseudophakic cystoid macular edema
Published on: 3rd January, 2019
OCLC Number/Unique Identifier: 7970379228
Cystoid macular edema is a common cause for unexplained painless vision loss after cataract surgery. Even the pathogenesis of pseudophakic cystoid macular edema (PCME) still remains undefined, it can most frequently occur in eyes with high vasoactive profile, had complicated cataract surgery such as posterior capsule rupture and risk of inflammation. Increased inflammation, ultimately leading to the breakdown of the blood-retinal barrier and cystic accumulation of extracellular intraretinal fluid. The natural history of PCME is spontaneous resolution without any treatment in most of patient, but it may take weeks or months, in addition permanent visual morbidity may occur in some cases. Therefore there is lack of consensus regarding treatment approach for this common ocular condition.
In this review treatment alternatives of PCME and its relation with underlying patho-physiologic mechanism are evaluated.
Assessment of Oral Hygiene awareness in Geriatric patients attending OPD at ESIC Dental College, Rohini, New Delhi
Published on: 2nd November, 2017
OCLC Number/Unique Identifier: 7379483324
Aim: To assess and learn oral health awareness and hygiene practices among geriatric patients and also to identify important barriers in the establishment of oral health services, disease prevention and oral health promotion programmes for the same.
Materials and Methods: A total of 500 patients in the age group of 50 years and above were selected using random sampling technique. A self‑administered structured questionnaire including 20 multiple choice questions was given to them. The results were analyzed using percentage.
Results: The result of this study shows an acute lack of oral hygiene awareness and limited knowledge of oral hygiene practices. In Rohini, few people use tooth brush.
Conclusions: Hence, there is an urgent need for comprehensive educational programs to promote good oral health and impart education about correct oral hygiene practices.
Characterization of senegalese races of Xanthomonas oryzae PV. oryzae to identify resistance genes to use
Published on: 19th October, 2022
Bacterial blight (BB), is a disease caused by Xanthomonas oryzae PV. oryzae (Xoo), was first reported in Senegal by Trinh in 1980. BB represents a severe threat to rice cultivation in West Africa. Characterizing the pathotypic diversity of bacterial populations is a key to the management of pathogen-resistant varieties. Pathogenicity tests show that all strains are virulent on the susceptible rice variety Azucena, and interact differentially with twelve near-isogenic rice lines, each carrying a single resistance gene. On this rice panel, six races were identified, two of which were previously reported in Mali (A3) and Burkina Faso (A1). Four races (S2, S4, S5, and S6) are described for the first time in Africa. Races A1, isolated in Ndiaye and Ndioum areas is the most prevalent in Senegal. The Xa1 gene controls 100% of the isolates tested and xa5 controls all isolates except S4 strains. The geographical distribution of Xoo races is contrasted. Four races are detected in the North and two in the South East of the country. Race S4 can be a major risk to rice cultivation because strains from this race are the most virulent and can only be controlled by Xa1. To identify local sources of resistance, we screened Xoo strains representative of the various races on twenty-three rice varieties grown by farmers in Senegal. Four rice varieties namely Sahel210, Sangangbye, Dansna2, and Sahel305 effectively control all the isolates tested. Our characterization of the first collection of Senegalese Xoo strains provided insight into the races present in the country and identified sources of resistance in local rice varieties. This information will help design effective breeding programs for resistance to bacterial leaf blight in Senegal.
Collegiate athlete with unilateral swollen arm after exercise
Published on: 8th June, 2023
A collegiate football player presented to the athletic training room with the complaint of intermittent left upper extremity swelling. Deep vein thromboses as well as abnormalities of the cervical spine were ruled out initially. He was referred to a vascular surgeon and diagnosed with McCleery Syndrome after evaluation of the thoracic outlet with dynamic ultrasound testing. He was treated surgically for decompression of his venous thoracic outlet syndrome and has since made a full recovery.
Search by University/Institution
Enter your University/Institution to find colleagues at HSPI.
Ensuring author's satisfaction with
- Friendly and hassle-free publication process
- Less production time of articles
- Constructive peer-review
- Enhancing journal reputation
- Regular feedback system
- Quick response to authors' queries
Most Viewed Keywords
- Groundwater
- Tilmicosin
- Lung cancer
- CMV
- New Zealand
- Pediatrics of disasters
- Case report
- TIMI
- Volume of fluid
- Hypocomplementemic urticarial vasculitic syndrome
- Hematopoietic stem cell
- Beta-thalassemia major
- Blood metabolites
- Inflammatory myofibroblastic tumor
- Large ICH
- Photonic bandgap
- Ionizing radiation
- Inadvertent bleb
- Diabetes
- Injury risk assessment
Search Articles by Country
Get all latest articles in all Heighten Science Publications Inc journals by country.
Testmonials
My candid opinion is that the service you render is second to none. My favourite part is the prompt response to issue, really i value that.
Abiodun Akanbi Adeogun
To the editorial team at HSPI and the Journal of Clinical Nephrology: Thank you so much for your hard work and collaboration in bringing our article to life. Your staff was responsive, flexible, and ...
Alejandro Munoz
Thank you and your company for effective support of authors which are very much dependable on the funds gambling for science in the different countries of our huge and unpredictable world. We are doin...
Russia
Victor V Apollonov
We thank to the heighten science family, who speed up the publication of our article and provide every support.
Mehmet Besir
"This is my first time publishing with the journal/publisher. I am impressed at the promptness of the publishing staff and the professionalism displayed. Thank you for encouraging young researchers li...
Ekiti State University, Nigeria
Adebukola Ajite
This is to specify that I have had an extensive and detailed interaction with the Editorial team of Annals of Clinical Gastroenterology and Hepatology, USA, lasting over a significant period of time. ...
New Delhi, India
Anubha Bajaj
Great, We are too comfortable with the process including the peer review process and quality. But, the journal should be indexed in different databases such scopus.
Afework Edmealem
I would like to thank JPRA for taking this decision. I understand the effort it represents for you. I'm truly happy to have the paper published in JPRA. And I'll certainly consider JPRA for my next pu...
Emmanuel BUSATO
The editorial process was quickly done. The galley proof was sent within a week after being accepted for publication. The editorial team was very helpful and responded promptly.
India
Rohit Kulshrestha
I like the quality of the print & overall service. The paper looks quite impressive. Hope this will attract interested readers. All of you have our best wishes for continued success.
Arshad Khan
Browse by Subjects
Biology Group Journals
Chemistry Group Journals
Clinical Group Journals
- Archives of Food and Nutritional Science
- Annals of Dermatological Research
- International Journal of Clinical Microbiology and Biochemical Technology
- Journal of Advanced Pediatrics and Child Health
- Journal of Pulmonology and Respiratory Research
- Insights in Clinical and Cellular Immunology
- International Journal of Clinical Anesthesia and Research
- Journal of Clinical Intensive Care and Medicine
- Journal of Clinical, Medical and Experimental Images
- Journal of Neuroscience and Neurological Disorders
- Insights in Veterinary Science
- Archives of Asthma, Allergy and Immunology
- Journal of Child, Adult Vaccines and Immunology
- Archives of Cancer Science and Therapy
- Clinical Journal of Nursing Care and Practice
- Annals of Clinical Gastroenterology and Hepatology
- Journal of Hematology and Clinical Research
- Archives of Pathology and Clinical Research
- Annals of Clinical Hypertension
- Journal of Oral Health and Craniofacial Science
- International Journal of Clinical and Experimental Ophthalmology
- Journal of Radiology and Oncology
- Archives of Clinical and Experimental Orthopaedics
- International Journal of Bone Marrow Research
- International Journal of Clinical Virology
- New Insights in Obesity: Genetics and Beyond
- Advanced Treatments in ENT Disorders
- Journal of Clinical Advances in Dentistry
- Insights on the Depression and Anxiety
- Heighpubs Otolaryngology and Rhinology
- Clinical Journal of Obstetrics and Gynecology
- Archives of Surgery and Clinical Research