A case report on Meigs’ syndrome and elevated serum CA-125: A rare case report
Published on: 24th March, 2021
OCLC Number/Unique Identifier: 9038781665
Meigs syndrome is an uncommon presentation, where a benign ovarian neoplasia presents along with ascites and pleural effusion. About 1% of ovarian neoplasia can present as Meigs syndrome. Patients with Meigs’ syndrome and elevated serum CA-125 are not frequently reported. We report a case of a 50-year-old women who presented with shortness of breath, cough, weight loss of one and half month duration. Chest radiograph of the patient with clinical examination of patient confirms pleural effusion as cause of progressive shortness of breath. The presence of a pelvic mass and elevated serum CA-125, which raised the possibility of malignancy. After complete resection of tumor, the pathologic reports confirmed a benign ovarian neoplasia. We highlight the importance of suspicion, careful general examination, radiological assessment and histological tests to confirm the diagnosis of Meigs’ syndrome.
Secondary Onychomycosis Development after Cosmetic Procedure-Case Report
Published on: 25th April, 2017
OCLC Number/Unique Identifier: 7286423138
The authors describe the unusual case of subungual onychomycosis, due to fluconazole and itraconazole resistant Candida albicans after using the hybrid and acrylic lacquers and nail tips. The etiology of these atypical changes was supported by isolation of the fungus from the nail lesions, and its consistent identification by means of morphological and molecular diagnosis. In the presented case, topical treatment with ciclopirox 8% nail lacquer allow to fight the pathogenic fungus but did not restore the natural appearance of the nails.
Andy Gump deformity
Published on: 22nd September, 2017
OCLC Number/Unique Identifier: 7286354685
A 63 year old gentleman presented with ulcer over the lower alveolus for the past 4 months duration. The patient also had pain, loose lower central incisors and occasional bleeding from the ulcer while brushing. On examination an ulceroproliferative growth was seen involving lower alveolus along with adjoining mucosa of the lower lip with mobile central incisors. There was associated bilateral submandibular area lymphadenopathy.
Research into the fundamental building block of quantum theorem of the unified force field
Published on: 28th March, 2023
This is a work based on the extension of the work of Professor James Clerk Maxwell and Albert Einstein into a new framework of science built on provable mathematical theorem which serves as a basis for unifications of the fundamental forces which all together have become impossible to unify under the current framework of General relativity and Quantum Field theory.It is to be used as a piece for inspiring new innovations, discovering and exploring the terrains of the difficult pathways in physics where our modern physical theories have failed.This work is meant to be adapted and used by various physics professionals who are working on extending the frontiers of physics or providing solutions to problems that cannot be handled by current physics framework. In summary it is an inspirational tool that hopefully will help our professional in physics out there.It interpretations and applications is subject to the personal inspirations the reader who is a professional can derived from the work for his or her personal usage.
Development of Gamma Flaw Detectors for Non-Destructive Testing
Published on: 11th October, 2023
The radiographic method of control is implemented by a set of control tools in the form of gamma flaw detectors, which are distinguished by: mobility, reliability, radiation safety, adaptability to a wide climatic range, ease of operation, and the ability to control products with small and large radiation thicknesses. The paper describes portable gamma flaw detectors manufactured by JSC NIITFA: Gammarid 2010R, UNIGAM R, Stapel-5 Se75 Ir192, Stapel-5 Se75W, gamma flaw detector γ-RID-75/80R and stationary gamma flaw detectors RID K-100 and RID K-400. Also paper describes a brief technology for the production of ionizing radiation sources Ir-192 with activity of 120 Curie, a technology for rolling the source holder with Ir-192 source and completing the Ir-192 source with a portable gamma flaw detector Gammarid-192/120M in the INP AS.
Application of Multi-criteria Decision-making Methods for Forensic Analysis of Mechanical Parts in Vehicle Accidents using q-Rung Orthopair Fuzzy Numbers
Published on: 31st October, 2024
This study explores the application of a Multi-Criteria Decision-Making (MCDM) approach based on q-rung orthopair fuzzy numbers to identify the origin of mechanical parts found at vehicle accident scenes. The primary objective is to determine the most likely vehicle to which these parts belong by evaluating key criteria such as compatibility, damage level, serial number matching, and color compatibility. Q-rung orthopair fuzzy numbers offer an advanced method to handle the inherent uncertainty and vagueness associated with forensic evaluations, particularly in scenarios where data is incomplete or imprecise. The proposed methodology involves defining the criteria, assigning membership and non-membership degrees using q-rung orthopair fuzzy sets, and applying an aggregation process to effectively rank alternatives. This approach facilitates flexible decision-making by accommodating different levels of confidence and uncertainty, making it particularly suitable for forensic applications where evidence is often ambiguous. The findings demonstrate that integrating q-rung orthopair fuzzy numbers into the MCDM framework significantly enhances the accuracy and reliability of identifying vehicle components involved in accidents. The proposed methodology provides a systematic tool to support forensic investigations, aiding in the determination of liability and contributing to more robust outcomes in mechanical evidence analysis.
Emerging Risk of Microplastics on Health, Agriculture and Environment
Published on: 30th April, 2024
Exposure to microplastics is unavoidable, and a vast amount of microplastics are traveling around the oceans. Microplastics are considered one of the major potential pollutants due to their exposure and interference with the health of humans, animals, aquatic species, agriculture, etc. Shockingly, the microplastic was also detected in the human placenta (fetal and amniochorial membranes), which could cause long-term effects on human health. The disposal of plastic into the oceans is the most happening process across the globe; thereby, microplastic pollution is evident, leading to a huge risk to marine species. Also, the accumulation of microplastics on soil or land leads to an increase in pH value, thereby affecting the surface water and soil-groundwater medium, eventually affecting plant and human health. At the same time, microplastics and their particles are found in milk, meat, and other edible items, which directly affects human health. The appearance of microplastic particles in insects, birds, animals, and even human blood indicates its adverse effect on the environment. This review has discussed the impact of microplastic on the health of humans, aquatic species, and agriculture.
Effects of Fast-Walking on Muscle Activation in Young Adults and Elderly Persons
Published on: 20th January, 2017
OCLC Number/Unique Identifier: 7286424597
Coactivation of agonist and antagonist muscles participates in the regulation of joint stiffness and postural instability. Alterations on muscle activity have been revealed as an important falling risk factor. It is unclear the effects, and age-related differences, of a prolonged demanding task on the muscular coactivation levels. We compared muscle activation amplitude and coactivation of the vastus medialis, biceps femoris, tibialis anterior, and gastrocnemius medialis from surface EMG in 16 young adults (age 21-33) and 8 elderly adults (age 66-72) while fast-walking at 70% of their maximum heart rate. Overall, the elderly demonstrated higher coactivation indexes than the young individuals. Ankle coactivation decreased in the first half of the swing phase, while coactivation at the knee increased in the latter half of the swing phase in our elders. Alterations of muscle activation and coactivation on the knee and ankle were more prominent close to landing and in the swing phase. Our results suggest that these alterations may suggest potential concerns with respect to the risk of falls.
Addition of Simvastatin to Carvedilol and Endoscopic Variceal Ligation improves rebleeding and survival in patients with Child-Pugh A and B class but not in Child Pugh C class
Published on: 20th September, 2019
OCLC Number/Unique Identifier: 8299602911
Background: Even with current standard treatment after variceal bleeding which includes combination of nonselective b-blockers and repeated endoscopic variceal ligation, the risk of rebleeding and mortality are high. Statins exhibit an antifibrotic effect and improves HVPG. We evaluated whether addition of simvastatin to carvedilol plus EVL therapy reduces variceal rebleeds or death in patients with cirrhosis.
Method: Patients with a variceal bleed 5 to 10 days before were randomly assigned to groups A [carvedilol (n = 69)] or group B [carvedilol (maximum dose - 12.5mg), and simvastatin (40mg/day) (n = 65)]. Primary end points were variceal rebleeding or death. Secondary end points were new complications of portal hypertension and serious adverse effects of drugs.
Results: During a mean follow-up of 49.05 ± 25.74 weeks, composite end point i.e. rebleeding or death developed in 23 patients (33.3%) in group A and 12 patients (18.5%) in group B [HR for simvastatin = 0.512; 95% CI: 0.254 – 1.030; p = 0.06]. In subgroup analysis by excluding patients of Child C class, 18 patients (34.6%) in group A and 7 patients (13.6%) in group B developed composite end point [HR for simvastatin = 0.369; 95% CI: 0.154 – 0.887; p = 0.026]. 17.4% and 15.4% patients in group A and B developed additional secondary complication [HR = 0.86; 95% CI: 0.345-2.161; p = 0.75). No simvastatin induced significant adverse effects were found.
Conclusion: Addition of simvastatin to carvedilol and EVL may reduce the rebleeding and death in patients with less advance liver disease.
Biological dose calculation using variable RBE in Single- and Multi-field Optimization IMPT plans for 3 Brain Tumor patients
Published on: 14th February, 2019
OCLC Number/Unique Identifier: 8022197964
Purpose: The purpose of this study was to evaluate biological dose in single-field optimization (SFO) and multi-field optimization (MFO) intensity-modulated proton therapy (IMPT) plans for brain tumor patients that used a fixed relative biological effectiveness (FRBE) and those that used a variable RBE (VRBE).
Materials and methods: SFO and MFO IMPT plans were planned by the Varian Eclipse treatment planning system for three brain tumor patients. Dose and linear energy transfer (LET) distributions for each plan were recomputed using an in-house fast Monte Carlo dose calculator system, and then biological dose distributions were calculated with a FRBE of 1.1 or with a previously published VRBE model. We then compared biological dose distributions obtained by the VRBE with those obtained by the FRBE.
Results: Doses obtained by the VRBE for the gross tumor volume and clinical target volume in all plans were 1%-2% larger than those obtained by the FRBE. The minimum dose obtained by the VRBE for the brainstem in the SFO IMPT of one patient was 140% larger than that obtained by the FRBE, but the difference was only 5.3 cGy (RBE). The difference in maximum dose for the optic chiasm in the MFO IMPT of another patient was less than 3.2%, but the dose difference was 149.2 cGy (RBE). We also found that no major differences were seen between the biological dose differences in the SFO IMPT plans and those in the MFO IMPT plans.
Conclusion: We could observe biological dose differences between the FRBE and the VRBE in the SFO and the MFO IMPT plans for brain tumor patients.
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