Novel Complication of Nusinersen Treatment: Hyponatremia
Published on: 15th October, 2018
OCLC Number/Unique Identifier: 7905949311
There are variations in therapeutic regimens of different liver diseases. The accurate diagnosis ensNusinersen treatment is a novel therapy for spinal muscular atrophy (SMA) type 1; consequently, the adverse reactions of the therapy, have not been well known, yet. The present study is a case report that declares a hyponatremia development after the nursinersen therapy. Since the therapy is quite new one and has limited practice, we hope that this rare complication will contribute to the scientific literature.
Sleeplessness and health
Published on: 30th April, 2019
OCLC Number/Unique Identifier: 8299525804
Sleep influences each intellectual and physical health. It’s essential for a person’s well-being. The reality is when we see at well-rested people, they’re working at an exclusive degree than people making an attempt to get by way of on 1 or 2 hours much less nightly sleep. Loss of sleep impairs your higher tiers of reasoning, problem-solving and interest to detail. Sleep deficit will additionally make people much less productive and put them at higher danger for creating depression. Sleep affects almost each tissue in our bodies. It influences growth and stress hormones, our immune system, appetite, breathing, blood pressure and cardiovascular health. Nurses play a foremost function in teaching and guiding the sleep deprived patients on the importance of sleep and its physiological and psychological effects.
Natural ferromagnetic resonance in cast microwires and its application to the safety control of infrastructures
Published on: 31st July, 2020
OCLC Number/Unique Identifier: 8656791643
The natural ferromagnetic resonance (NFMR) in cast glass-coated amorphous magnetic microwires has been studied theoretically and experimentally. The NFMR reveals large residual stresses appearing in the microwire core in the course of casting. These stresses, together with the magnetostriction, deteRmine the magnetoelastic anisotropy. Beside the residual internal stresses, the NFMR frequency is influenced by external stresses applied to the microwire or to the composite containing the latter (the so-called stress effect).
The dependence of the NFMR frequency on the deformation of the microwires is proposed to be used in the distant diagnostics of dangerous deformations of critical infrastructure objects such as bridges, dams, wind turbine towers, skyscrapers, stack-furnaces, embankments, etc. To this end, fragments of magnetic microwires will be embedded in the bulk of concrete structures or fixed on their surface during construction or after it by means of coating with a special concrete-adhesive plaster. Further, these structures are periodically irradiated with microwaves from a radar at frequencies close to the original NFMR, and the presence of latent dangerous deformations of the concrete structure is judged by the NFMR frequency shift.
Cleat-surface Interface and Lower Extremity Injuries
Published on: 28th September, 2023
Non-contact injuries with playing surfaces occurring from applied player impact and frictional forces are a major source of lower extremity injuries in competitive sports. Artificial playing surfaces are a common alternative to natural grass surfaces; however, these surfaces are associated with player injury as well. The purpose of this manuscript is to explore the existing literature on the relationship between cleat surface interface and lower extremity injuries in athletes and the importance of proper playing surface conditions alongside proper cleat selection to optimize injury prevention and athletic performance. As artificial turf has become more advanced, studies have shown the rates of lower extremity injuries of the knee, ankle, and foot have decreased to be more similar to the rate of injury on natural grass. However, foot and ankle injury rates remain significantly higher on artificial turf. Furthermore, certain studies continue to demonstrate an increased rate of knee injuries in football players, suggesting that significant performance differences still exist between artificial turf and natural grass. Future studies warrant focusing on ways to improve the cleat-surface interface of new-generation turf, emphasizing proper cleat selection, and playing surface conditions for injury prevention thus optimizing athletic performance.
Peculiarities of photon emisson of whole non-diluted human blood obtained from healthy donors and patients with some diseases
Published on: 31st December, 2018
OCLC Number/Unique Identifier: 7991708311
Blood plays an important role in oxygen absorption and its transfer to organs and tissues in vertebrates, as well as in a number of invertebrate species. Numerous interactions between cellular and non-cellular blood components constantly occur. A special role in these interactions belongs to erythrocytes and leukocytes, between which oxygen is constantly exchanged and activated, which we showed directly in whole blood. Blood is a liquid tissue, which is a complex cooperative system and has many inherent functions and the most important one is the ability to maintain the homeostasis of the body. Our experience has shown that despite its high optical density, undiluted blood of humans and animals can be a source of radiation due to the transformation of the energy of electron-excited (EEE) states and secondary processes occurring in the whole blood system. Parameters of this radiation - ultra-weak photons emission (UWPE) from blood - depend upon its physiological properties and reflect the physiological state of a donor. Analysis of UWPE from non-diluted blood is a simple and sensitive method that allows to monitor the course of treatment of a patient. In spite of high opacity of non-diluted blood it may be a strong source of UWPE both in the presence and absence of UWPE enhancers. Analysis of patterns of UWPE from blood reveals its highly non-linear, stable non-equilibrium and cooperative properties. Characteristic of a living system.
Comparative Activities of Stem Bark Extracts of Anthocleista vogelii, Bligha sapida, Voacanga africana and Momordica charantia Leaf against Plasmodium berghei- berghei in Mice
Published on: 5th August, 2025
Background: The search for antimalarial molecules from plants necessitates comparative studies of ethnomedicinal antimalarial plants to quickly identify those that may be used in further search. Therefore, the median lethal dose, LD50, and the antiplasmodial activities of the methanol extracts of the stem barks of Anthocleista vogelii, Bligha sapida, Voacanga africana, and the leaf of Momordica charantia were evaluated against Plasmodium berghei berghei-infected mice using prophylactic, chemosuppressive, and curative models to compare their activities and identify the most active for further evaluation. Methods: The plant materials were collected, authenticated, and voucher specimens were deposited at the Faculty of Pharmacy Herbarium, OAU, Ile-Ife. They were separately macerated in methanol, and the median lethal dose, LD50 determined using Lorke’s method. The percentage parasitaemia, percentage reduction, chemosuppression and clearance, survival time, and percentage survivor of each, in the three models of antiplasmodial test against Plasmodium berghei berghei infected mice were assessed. Pyrimethamine and Chloroquine were positive controls, while normal saline was a negative control. One-way analysis of variance (ANOVA) followed by Student Newman-Keuls post hoc test (p < 0.05) was used for the analysis of data. Results and Conclusion: The lowest prophylactic ED50 and ED90 values 304 and 624 mg/kg of AV, comparable chemosuppressive ED50 values of all extracts and the significantly (p < 0.05) lower values of ED50 and ED90 of MC and VA in the curative assay can guide the selection of the plant extract(s) for further antimalarial evaluation.
Pharmacological Manipulation of the Aging Pathways to Effect Health Span and Lifespan with Special Reference to SGLT2 Inhibitors as Powerful Anti-aging Agents in Humans
Published on: 30th October, 2024
Calorie restriction has been shown to slow the aging process in numerous organisms including primates. Caloric excess states, such as type 2 diabetes, are associated with accelerated aging and the incidence and severity of chronic diseases. The nutrient-sensing pathways and intestinal microbiome are important systems that affect aging and chronic disease development. This manuscript reviews the various pathways involved with aging and chronic disease development and examines the pharmacological manipulation of these systems which appear to slow aging and the chronic diseases of aging in experimental model organisms and collaborating human data when available. Finally, the abundance of experimental and human data suggesting the newer diabetic medications, the sodium-glucose transport inhibitors, are potent anti-aging agents is provided.
Texture Analysis of Hard Tissue Changes after Sinus Lift Surgery with Allograft and Xenograft
Published on: 29th April, 2024
In the realm of dental surgery, implants are essential for replacing missing teeth. To facilitate implant placement, techniques such as bone grafting and sinus lifts are utilized to augment the volume of atrophied alveolar bone in candidates for dental implants. Typically, patients undergo a period of recovery following bone grafts before proceeding with implant placement. This study investigates the efficacy of Cone Beam Computed Tomography (CBCT) in measuring the residual bone volume and assessing bone quality after the healing phase. A texture analysis was conducted on CBCT scans from 42 patients requiring maxillary sinus lift reconstruction. These patients were categorized into two groups based on the type of grafting material used: Xenograft or allograft. The study analyzed the distribution of various texture parameters and conducted a Mann-Whitney U test to identify significant statistical differences between the groups. Results indicated non-normal distributions for specific variables such as Area_S(1,0) and S(1,0)SumOfSqs, while others like S(1,0)Entropy displayed normal distributions. The findings revealed no significant statistical differences in the primary outcomes between the xenograft and allograft groups. However, the average values of the gray shades of pixels in the allograft group were statistically significantly higher compared to the xenograft group, suggesting differences in bone texture post-procedure.
Symmetry of Shank Muscle Strength, Passive Stiffness and Plantar Pressure Following IASTM Accompanied by Electrotherapy in a Case with Severe Ankle Stiffness
Published on: 14th November, 2024
Excessive ankle stiffness can greatly impact mobility, leading to discomfort, difficulty in walking, and limited Range of Motion (ROM). We aimed to identify and address the symmetry of shank muscle strength, ankle passive stiffness, and plantar pressure distribution, in a patient with unilateral excessive ankle stiffness, utilizing Instrument-Assisted Soft Tissue Mobilization (IASTM) accompanied by Faradic Electrical Stimulation (FES).The patient’s muscle strength and ROM which had diminished due to 3.5 years of ankle immobilization post-rescue from amputation, underwent a 12-week program involving IASTM and FES. The plantar and dorsiflexion muscles’ torque, ROM, and plantar pressure were measured using an isokinetic and plantar distribution system before and after the intervention. Symmetry of muscle torque, ROM, and plantar pressure between two limbs were calculated for pre and post-test.Results indicated improvement in the ratio index of the concentric/eccentric dorsi- and plantar-flexion peak torque and dorsi- and plantar-flexion work, ROM, gait line length, and contact time after a 12-week intervention.The study suggests that IASTM and FES are effective interventions for restoring symmetry in a patient with post-operation complications, highlighting the need for further research on similar cases.
Value of ambulatory blood pressure measure in pregnancy hypertension
Published on: 9th November, 2018
OCLC Number/Unique Identifier: 7929243019
It is still not well known the prognostic cardiovascular value of 24h ambulatory blood pressure monitoring in the pregnant woman with hypertension.
Objectives: Assess to the prognostic value of ABPM parameters in predicting maternofetal event.
Methods: Retrospective and observational study which included 166 pregnant women.
Results: The authors found that the night time DBP was the best predictor of adverse events. Non-dipper profile had worse survival at follow up until delivery compared to those with a dipper profile.
Conclusions: ABPM is a tool for pregnant with HT because this is the unique method available that analyses the night blood pressure.
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