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The study aimed to investigate the threats to the biodiversity of ethnomedicinal plants and to find consensus information on conservation and management practices of ethnomedicinal plants to contribute sustainable utilization of ethnomedicinal plants in Kore district, Southeastern Ethiopia. The result of the survey revealed that sixty-one medicinal plants were reported by the informants from the study area. These plants are distributed in 59 genera and 37 families. Family Lamiaceae and Asteraceae were represented by 5 (8.2%) species for each family and this is the highest number of species and followed by 4 (6.5%) species of Solanaceae and Fabaceae for each family. Preference ranking analysis shows that Eucalyptus globulus scored 47, indicating that it is the most used plant for firewood in the community, followed by Olea europaea (45) and the least used plant for firewood is Juniperus procera scored 36. Paired comparison analysis showed that Olea Europeae ranked first followed by Podocarpus falcatus for the use of charcoal production in the study area. The major purposes of plant species in the study area were construction, Charcoal, Firewood, Furniture, and Fences as well as for medicinal uses. Based on direct matrix ranking analysis Juniperus procera, Eucalyptus globulus, Podocarpus falactus, Olea europaea, Hagenia abyssinica, Croton macrostachyus, and Cordia africana were the most preferred medicinal plants by local people in the study area. The analysis's findings indicated that anthropogenic influences are endangering medicinal plants. In this study area, only about 13% of medicinal plants are collected from home gardens. This shows that the effort made by the community to conserve medicinal plants is not satisfactory. Therefore, encouraging NGOs and Government offices to participate in the conservation of medicinal plants to encourage the local people to plant indigenous trees for domestic use is necessary.

Cholangiocarcinoma (CCA), a rare malignancy originating from bile duct epithelial cells, often presents a challenging prognosis due to its rarity, delayed diagnosis, and early recurrence post-curative-intent treatments. Additional complexities include difficulties in achieving R0 resection during surgical intervention and the lack of effective second-line treatments following the failure of first-line regimens, particularly in unresectable advanced cases.In this case study, we demonstrate a durable response to a combination regimen of pembrolizumab and lenvatinib in a patient with distal CCA. Despite the regimen’s interim median Progression-Free Survival (PFS) of 6.1 months (95% CI, 2.1-6.4), our patient achieved a clinical and radiological PFS of approximately two years. The underlying mechanisms, potentially involving the upregulation of immune response pathways through undisclosed means or influenced by lenvatinib’s activation of T cells, might augment the sensitivity to PD-1 antibodies like pembrolizumab, contributing to the patient’s sustained response over two years.This case also highlights the significance of the patient’s initial good health condition, multidisciplinary care, and the potential impact of molecular subtyping on treatment selection in a patient with distal CCA who underwent numerous diagnostic procedures, intricate surgical interventions, and subsequent treatment regimens over seven years. Additionally, we underscore significant landmark trials and emerging combination therapies, including chemotherapies, immunotherapy, and targeted treatments in this report.

Bacteria has been known to grow in pipes of water distribution systems and bottled drinking water. Its growth in reusable drinking water bottles is not clear even though they have become more popular and used by children and adults daily everywhere. This study found that there is an extremely high level of bacteria content and a rapid microbial growth in reusable drinking water bottles. The bacteria content tested by heterotrophic plate count (HPC) is in a range of 0-2.4x105 CFU/mL with an average of about 34,000 bacteria counts/ml for bottles used by children and 75,000 bacteria counts/ml for bottles used by adults. Bacteria number can quickly increases to 1-2 million counts/ml in the bottles one day later. Considering the high level of HPC bacteria content in the reusable drinking water bottles, it may be necessary to have some control measures to reduce the bacteria level and to minimize the associated likely health risk of the disease spreading since many people use reusable water bottles every day. 

The carried work has based on transient vibration response of multiple degrees of freedom (MDOF) system. By this work study of Time–history analysis and prediction of the displacement for excitation has done. For the MDOF system, we have taken the four-storey building to done transient vibration. We establish the equivalent spring-mass system. Transient analysis has done for both Undamped and Damped of the forced system of multiple degrees of freedom (MDOF) system. In the case of the Damped system, we have done three stages of damping, i.e., (1) Underdamped system, (2) Critically damped system, (3) Overdamped system. The time-history graph obtained for two different time stages i.e. 0.001 sec & 0.01 sec with initial time 0.000001 sec. The natural frequency has determined by both theoretical calculation and ANSYS. The whole study of transient vibration makes it possible to predict the damping values that oppose any kind of sudden impact or force vibration, such as blasts, earthquakes and tsunamis. The ANSYS is the modelling and simulation software is used to perform the transient vibration response. The Mode Superposition method is used by ANSYS to calculate the structure response

Assuming that the road infrastructure has been implemented in accordance with specifications and standards, poor adhesion between the two layers of asphalt mix can be a significant cause of pavement problems. The general problem observed with the weak adhesion between the layers is the slip failure. Slipping disruption in areas where transport acceleration increases, in areas where acceleration decreases or may occur in bumps. One of the criteria and a test method for measuring adhesion resistance between the hot mix asphalt layers is needed to improve the surface finish. The main objective of this study is to determine the effect of reducing the coefficient of friction between asphalt layers in the displacement of asphaltic layers. Because performing experimental experiments in the country is a deterrent to this goal, the use of analytical and numerical methods has been shown to play an important role in conducting studies. Therefore, in this paper, using vehicle simulation in ABAQUS software and analyzes, it has been found that decreasing the coefficient of friction (adhesion reduction) increases the interlayer deformation, which causes the surface of the pavement to fail. Three different thicknesses for asphalt cladding, including 4, 6, and 7 centimeters, and three different thicknesses for roller concrete layers of 18, 20 and 22 centimeters are used. Modeling and analysis of pavements with finite element method has been performed and the depth of the asphalt and tensile strain slope is calculated at the maximum level. The results show that the type of asphalt mix has a high impact on the amount of sloping and tensile strain at the maximum level. So that under different conditions it is estimated to be about 2-3 times in the amount of rotation at the surface. Also, the amount of groove and strain in the middle of the procedure is increased by a thickness of 11% the thickness of the roller concrete thickness has not changed, but the surface strain has been reduced by 9%.

Frequency specific microcurrent (FSM) has been used to treat myofascial pain syndrome [1,2] fibromyalgia associated with spine trauma [3], delayed onset muscle soreness [4], acute and chronic neuropathic pain [5] and chronic scarring in burn patients [6]. In this case, its use was modified to include not only the treatment of neuropathic pain but the treatment of neural adhesions in a patient with a ten year history of pain at rest and painful restricted range of motion following an ulnar nerve anterior transposition surgery in 2001. Eleven standard physical therapy sessions including augmented soft tissue mobilization using plastic tools, and muscle strengthening exercises and stretching failed to resolve symptoms. Three sessions of frequency specific microcurrent produced complete resolution of pain and symptoms. Patient remained symptoms free at one-year follow up.

Erosion has become widespread in the local climatic conditions of Azerbaijan. From this point of view, different types of erosion (washing, erosion, deflation, etc.) can often be found in many soil types formed in the territory of the republic. It should be taken into account that as a result of erosion, the top fertile layer of the soil is washed away and as a result, the soil is deprived of the humus layer. In the presented article, the effect of relief elements on the erosion processes occurring in the lands of Gadabay region was studied on the basis of GIS technologies.

The article describes the gamma activation analysis method used to determine the gold content in rock samples using the Aura measuring complex. The physicochemical basis of gold extraction in the process of cyanide leaching is considered. The technology for extracting gold from solutions of tailing waste “ponds” of tailings dumps of hydrometallurgical plants of the Joint Stock Company “Navoi Mining and Metallurgical Combine” (JSC NMMC) is presented. It has been shown that in the dynamic mode of sorption of tailing waste solutions acidified to pH = 3.3÷3.5 through AM-2B and VP-1P ion exchange resins, gold is sorbed on the AM-2B anion exchanger up to 3.9 mg/g and on the VP-1P anion exchanger up to 1.5 mg/g. It has been shown that when solutions of tailing waste are exposed to ammonia, ammonia complex compounds of base metal impurities are formed, which decompose, while the gold cyanide complex does not decompose and is sorbed on the AM-2B ion exchange resin up to 3.0 mg/g. The mechanisms of the chemical reactions of the process of extracting gold from tailing waste and the technological scheme of the installation for extracting gold from solutions of the tailing waste “pond” are presented.

Introduction: Obesity is a global-level epidemic. Together with this disease, called chronic subclinical inflammatory disease, many other diseases, known as comorbidities, arise. Objective: To show that the association between low-level laser therapy and physical exercise is supported, by experimental and clinical studies, being an instrument that maximizes the treatment of obesity as well as its comorbidities. Conclusion: This manuscript brings a compendium of accomplished work by our group that allows understand the mechanism base of interaction between the photonic technology and the physical exercise, allowing to potentiate the treatment of the obesity.

German universities of applied sciences have provided a large number of technical talents to society, and have made significant contributions to the enhancement of German education and industry. Drawing on the professional construction experience of German universities of applied sciences, this paper summarizes the path of civil engineering materials courses in China's high-level applied universities. The proposals for curriculum reform were discussed. Colleges and universities can cultivate professionals with strong hands-on abilities, strong exploration abilities, and a scientific research spirit. In addition, this paper puts forward that China needs to make changes from three levels: the country, universities, and teachers. Based on learning from the experience of collaborative education between teaching and scientific research in German universities, we have embarked on a road of education with China characteristics.