Comparison of Visual Field Progression in Patients with Primary Open Angle Glaucoma and Pseudo Exfoliative Glaucoma
Published on: 9th May, 2025
Objective: Comparison of visual field progression in patients with Primary Open-angle Glaucoma (POAG) and Pseudo Exfoliative Glaucoma (PEXG).Methods and materials: This is a 2-year longitudinal prospective study including 60 glaucomatous eyes with VA CF ≥ 3 m, IOP ≥ 20 mmHg, CDR ≥ 0.6 and those with Shaffer’s grade 3 or above were categorized as POAG along with signs of Pseudo exfoliative material as PEXG.Patients on anti-glaucoma medications and those who have undergone cataract and glaucoma surgeries are also included in this study. 24-2 visual field test was performed using Humphrey Field Analyzer & the progression was assessed based on 3 parameters- Mean Deviation (MD), Visual Field Index (VFI) & Guided Progression Analysis (GPA).Results: The difference in MD & VFI was higher in PEXG (-5.77 dB) (10.88%) than in POAG (-1.56 dB) (7.17%) respectively & was significant statistically (t - test, p = < 0.001). The GPA showed fast progression in 53.30% of cases in PEXG, 13.30% in POAG (Chi-square, p = < 0.001) about 63.30% of POAG & 46.70% of PEXG showed slow- moderate progression, but 23.30% of POAG subjects had no progression.Conclusion: Compared to POAG, the study showed that PEXG had frequent & faster visual field worsening. Therefore, PEXG patients require more stringent management & treatment than those with POAG.
The place of health innovation in space to improve the lives of earthlings
Published on: 27th August, 2019
OCLC Number/Unique Identifier: 8264378479
For over twenty years, following the creation of space stations, MIR first and then the ISS (International Space Station) men (3 to 6) live and succeed each other continuously about 300 - 400 km of altitude to make scientific experiments. For this reason sending men into space has become an activity “almost banal or regular “but this remains potentially a very dangerous environment for the adapted manon Earth and thus requires medical monitoring to ensure the health of astronauts and the persistence of their ability during their mission. In general, the medical benefits on Earth of space conquest go far beyond envy and the need for man to discover the cosmos but to develop many tools medicines to also offer solutions for all living beings on Earth!
Survey on the Underutilization of Forensic Expertise in India: Examining the Dominance of Law Enforcement in Evidence Collection and Investigations
Published on: 22nd May, 2025
Forensic science can significantly enhance criminal investigation equity and accuracy. In India, though, forensic experts remain underutilized as case investigations are predominantly performed by law enforcement agencies. This article documents findings of a survey of 230 respondents half of them being forensic experts and other non-forensic respondents like law enforcers exhibiting a wide perceptual gap. While forensic experts emphasize the need for independent intervention so that objective outcomes would be achieved, police respondents strongly favor conventional investigation methods. Systemic barriers like training constraints, availability limitations, and formalization of processes also discourage effective integration of forensic science. The research highlights efforts at policy reform that accord forensic experts a more active role, thereby strengthening the credibility and objectivity of India’s justice system.
Comparative Analysis of Water Wells and Tap Water: Case Study from Lebanon, Baalbeck Region
Published on: 5th September, 2024
Water deficit is a fundamental factor in public health and economic growth. Water supply and population growth are directly linked to water demand. The physio-chemistry and microbiology analysis of water is utmost significance in dietary requirements. Drinking water has the main concern especially it affects food security. This study includes a number of representative sites where 24 water samples (from wells, reservoirs and tap water) were analysed. These sites are located in the western villages of Baalbeck, the main city of the Bekaa Plain in Lebanon where the analysed water is used mainly for domestic needs and for irrigation. This study investigates the physiochemical and microbiological properties. Among the selected sites, Hawsh Barada site shows a strong contamination by nitrate. At the Nabi Rashaded (tap), Beit Shema and Bednayel (borehole and tap), contamination above the norm by zinc ion was noted. From a microbiological point of view, Hawsh barada, Nabi-Rashadeh, Hawsh-bay, and Beit shema are markedly polluted and do not meet the standard for drinking water. Hence, water quality in Hawsh barada, Nabi-Rashadeh, Hawsh-bay, Beit shema and Bednayel are not suitable for drinking, and this must be informed to decision makers who can act implementing environmental controls for health protection in the studied region.
Techno-econophysics’ Fractal Involving of Exergy Remarks
Published on: 4th September, 2024
Inclusively new to econophysics studies, herewith proposed technoeconophysics as part of techno-economy, econophysics & sociophysics to interpret the description between probability and hypothesis found between fractal realms and econophysics of markets, physics markets, or stock markets any chaotic evidence [exergy destructive] could present if effective & efficient criterion doesn’t comply. A more precise iterative study ought to be held to configure how fractal dimension is involved in the techno-econophysics study of the Helium Nat Gas Project which is not integer, but also proofed numerically & analytically.
Spiritual and religious Islamic perspectives of healing of posttraumatic stress disorder
Published on: 25th September, 2017
OCLC Number/Unique Identifier: 7317656145
It is known today that psycho-trauma and PTSD cause different levels of mental and social dysfunction. Human spirituality and capacity to meet further life difficulties become severely damaged. There is wide accepted attitude today that in holistic approach in process of healing PTSD and psycho-trauma is necessary to include other professionals from community resource regarding needs of trauma victims. In Bosnia and Herzegovina after very severe war (1992-1995) as mental health professionals, we are faced with increasing number of different mental health disorders as result of severe trauma experiences. Regarding community based care orientation it is necessary to include and religion professionals. According national and religious background of majority of our population in Tuzla Canton that is Muslim, we meet spiritual needs of our clients as needs for Islamic explanation of life and death meaning. Our clients need to talk about spiritual issues in daily therapy and to practice daily religious rituals. Regarding that in this paper we tried to interface Islamic principles and it’s beneficial toward psycho-trauma and PTSD, as well as Muslim perspectives in attempt to apply spiritual practice in therapeutic tools for better efficacy in spiritual healing of mental dysfunction’s of believers who survived severe trauma, especially war trauma.
Impact of Thin Endometrium in Frozen Embryo Transfer: Thesis Summary Article
Published on: 13th June, 2025
Background: Endometrial Thickness (EMT) is considered an important prognostic factor in assisted reproductive technology (ART), particularly in frozen embryo transfer (FET) cycles. Thin endometrium (< 7 mm) is often associated with implantation failure and reduced pregnancy rates, although its precise impact remains controversial.Objective: This thesis summary evaluates the role of thin endometrium in FET cycles, discusses etiologies, diagnostic modalities, treatment approaches, and reviews available patient data.Methods: We retrospectively analyzed 69 patients who underwent FET at Saveetha Medical College. Endometrial thickness was assessed via transvaginal ultrasound. Various treatment strategies including hormonal therapies (estradiol, progesterone), vasoactive agents, granulocyte colony-stimulating factor (G-CSF), platelet-rich plasma (PRP), L-arginine, sildenafil citrate, vitamin E, pentoxifylline, and stem cell therapy were reviewed for their efficacy in improving endometrial receptivity.Results: Endometrial thickness < 7 mm correlated with lower pregnancy rates compared to patients with thickness ≥ 7 mm. Hormonal and adjuvant therapies reported varying degrees of success in improving EMT and subsequent pregnancy outcomes. Vascularity, angiogenesis, and Doppler studies also demonstrated a significant association with endometrial receptivity.Conclusion: Thin endometrium remains a critical challenge in ART cycles. Multimodal therapeutic approaches may improve outcomes; however, larger prospective studies are required to establish standardized protocols. Our patient data support that even minimal increases in EMT can enhance implantation success.
A Brief Dig into the Potent Medicinal Plant Phyllanthus Amarus Schum. and Thonn.
Published on: 27th March, 2024
Phyllanthus amarus Schum. and Thonn., a plant of substantial medicinal significance, is known for its usage in the ‘Ayurvedic’ system of medicine for over 2000 years. This herb grows throughout the world including India. P. amarus along with other species of its genus has been a vital part of several herbal formulations available in the Indian market under the trade name Bhuiamlaki. Several pharmacognostic evaluations over the years established the genus Phyllanthus of great commercial value. Ethnopharmacological studies conducted with P. amarus to date have shown its diverse therapeutic usage globally. This owes to the vast array of secondary metabolites present in the herb, substantially in the leaf tissue. Different analytical and phytochemistry studies performed across the globe revealed that P. amarus is a hub of various classes of secondary metabolites viz. lignans like phyllanthin, hypophyllanthin, flavonoids, alkaloids, triterpenes, sterols, volatile oil, ellagitannins including simple and complex tannins, etc. Different analytical techniques have been employed over the past years for isolating and studying these varied secondary metabolites. Further, bioactivities and pharmacological properties of P. amarus that were mainly due to the presence of these wide arrays of secondary metabolites have also been explored extensively across the globe by several research groups. This plant has also been explored at molecular and transcriptome level, although relatively lesser but its extensive molecular and transcriptome analysis have only been performed from our lab. Thus, P. amarus has considerable potential to be explored in the future as a significant therapeutic source not only in the traditional medicinal system but also in the modern pharmaceutical industry.
Chronic Pancreatitis with Stones: What is the Best Way to Treat?
Published on: 16th June, 2025
Pancreatic duct stones (PDS) are a common complication of chronic pancreatitis (CP). PDS can lead to duct obstruction and cause chronic abdominal pain. Ductal stone clearance, as well as short and long-term pain relief, is the cornerstone of endoscopic or surgical treatment. A step-up approach seems reasonable in pancreatic duct stone clearance. Extracorporeal shock wave lithotripsy (ESWL) combined with standard endoscopic retrograde cholangiopancreatography (ERCP) is as effective as a surgical approach for treating painful CP with less morbidity and medical costs. Therefore, endotherapy is considered a first-line therapy in selected patients. In case of insufficient pancreatic ductal clearance or strictures, advanced endoscopic techniques, per-oral pancreatoscopy (POP) with intraductal lithotripsy and/or endoscopic ultrasound-guided ductal drainage (EUS-PDD), will expand the role of the endoscopic approach. Because these new techniques are challenging, technically complex, and with high adverse events (AEs), they should be reserved for advanced tertiary care centers. Although there is increasing data that early surgical intervention may lead to better pain control and pancreatic duct stone clearance, surgery is reserved for patients failing endotherapy or patients with suspected malignancy.
The Use of Machine Learning Decision Tree Algorithms in Phenotyping Acute Respiratory Distress Syndrome (ARDS) Based on Clinical, Radiological, and Biological Heterogeneity- A Review
Published on: 8th July, 2025
Background: Acute Respiratory Distress Syndrome (ARDS) is a clinically, radiologically, and biologically heterogeneous condition. This variability contributes to diagnostic challenges and inconsistent responses to therapy. Identifying homogeneous subgroups or phenotypes within ARDS may enhance precision medicine and therapeutic targeting.Objective: This review evaluates the utility of decision tree–based supervised machine learning (ML) algorithms—specifically CART, Random Forest, and AdaBoost—in phenotyping ARDS using clinical, radiological, and biological data.Methods: A comprehensive literature search was conducted between December 2023 and March 2024 using PubMed and Google Scholar. Search terms included ‘decision tree in ARDS’, ‘phenotype in ARDS’, and ‘ML in hypo- and hyperinflammatory ARDS’. Twenty-six relevant articles were included, comprising original studies and reviews.Results: Decision tree–based models have demonstrated significant potential in classifying ARDS subtypes using routine clinical variables, radiographic features, and biomarker profiles. These algorithms have shown strong predictive performance in differentiating inflammatory phenotypes, forecasting mortality, and enabling early ARDS prediction.Conclusion: Decision tree algorithms offer a promising approach to ARDS phenotyping by leveraging routinely available data. Their interpretability and predictive accuracy may aid in translating complex biological insights into bedside clinical decision-making, advancing personalized care in critical illness.
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