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Lichen Planopilaris is known as the form of Lichen Planus typical of the scalp. It is classified as a lymphatic disease and is characterized by chronic inflammation which leads to cicatricial alopecia. Its causes are not yet well characterized but its etiology seems to strongly correlates with infection, sensitization and pollution. A clear and objective diagnosis of Lichen Planopilaris is not simple but the evolution and strongly negative outcomes on scalp of people affected by, pose the need of an early diagnosis. In this work we report the case of a 27-year-old male and a 54-year-old female, respectively, in which a correct diagnosis of Lichen Planopilaris, followed the incorrect previous ones, was made by means of dermatoscopy and histopathological analysis, decisive tools for the diagnosis of this kind of pathology.

Veterinary and agricultural surfactants are supposed to be inert additives, yet these substances commonly exert biological side-effects, in given cases synergistic with those of the active ingredients of these preparations. This is explicitly seen in altered toxicity of veterinary or pesticide formulations compared to their active ingredients alone. Neither the individual effects of these excipients, nor such combination effects are well-studied in toxicology, and therefore, possible toxicity consequences are occasionally not being considered at sufficient significance in the authorization, use and control of these substances. Risk assessment of these substances should cover all hazards they may represent, and corresponding levels of exposure. Surfactants used in veterinary and pesticide formulation enter the environment either by direct dispersion or by indirect release through excrement, leaching, sewage waters or sludge, and in turn, create potential exposure to a number of non-target organisms. Biochemical and (eco)toxicological hazards recently identified regarding certain agricultural surfactants include cytotoxicity (on cell lines of epithelial, neural and other tissues, as well as stem cells and tumor cells), endocrine disrupting effects, as well as aquatic ecotoxicity. This Mini Review summarizes toxicological effects identified in our studies in aquatic toxicity tests, in cell viability and cytotoxicity tests, in estrogenic activity assays, correlated with biochemical analysis of the surfactants and their decomposition. The conclusions are hoped to facilitate environmentally precautious revision of surfactants widely used in agriculture.

Background and aims: Iron deficiency is one of the most important health issues in adolescents, especially girls. Today, empowerment is considered an effective program to change behavior in chronic disease control. This study was conducted to determine the effect of the family-centered empowerment model on the empowerment indicators of student girls with iron deficiency anemia and their mothers.Methods: This is a two-group semi-experimental study conducted on 60 student girls along with their mothers, who were selected by a two-stage cluster random sampling method. Data was collected using a demographic information questionnaire and an adolescent and mother empowerment questionnaire. The intervention based on the family-centered empowerment model was implemented for the test group, and after 1.5 months, data from both groups were collected and analyzed with chi-square, independent t, and paired t-tests.Results: The results of the independent t-test showed that there was a significant difference between the student girls in the test and control groups after the intervention in terms of empowerment indicators (p < 0.05). The results of the independent t-test showed that there was a significant difference between the mothers in the test and control groups after the intervention in terms of ability indicators (p < 0.05), while before the intervention, this difference was not significant (p > 0.05). Conclusion: The results of the present study showed that the implementation of the family-centered empowerment model not only increased the empowerment indicators of student girls with iron deficiency anemia but also had an effect on the empowerment of their mothers.

The article evaluates the features of the course of chronic HBV infection in children with the background of anemia of inflammation. A brief description of the clinical and laboratory manifestations of the disease is given, depending on the course of anemia and inflammation. The data on hepcidin dynamics are analyzed. The stage–by-stage formation of iron metabolism disorders was revealed, in the form of a true deficiency with a breakdown of ferrokinetic markers – an increase in hepcidin and soluble transferin receptors with the background reduced ferritin values characteristic of iron deficiency anemia in the initial stages of the disease and, redistributive iron deficiency - decrease in hepcidin and soluble transferrin receptors with the background increased ferritin values characteristic of iron overload the body is in the late stages of the disease.

Neurotoxicity is increasingly recognized as a critical factor impacting long-term health, with growing evidence linking it to both neurodevelopmental and neurodegenerative diseases. Pesticides, widely used in agriculture and industry, have emerged as significant contributors to neurotoxic risk, given their capacity to disrupt key neurodevelopmental processes at low exposure levels. As conventional animal models present limitations in interspecies translation, human-derived neuron-based in vitro screening strategies are urgently needed to assess potential toxicants accurately. Human-induced pluripotent stem cells (hiPSCs) offer an innovative and scalable source for human-specific neuronal models that complement traditional animal-based approaches and support the development of predictive assays for neurotoxicity. Recent various stem cell models, including 2D cultures, 3D organoids, and microfluidic systems, are now available, advancing predictive neurotoxicology by simulating key aspects of human neural development and function. With the integration of High-Throughput (HT) and High-Content (HC) screening methodologies, these hiPSC-based systems enable efficient, large-scale evaluation of chemical effects on neural cells, enhancing our ability to detect early biomarkers of neurotoxic effects. Identifying early biomarkers of neurotoxic is essential to developing therapeutic interventions before irreversible damage occurs. This is particularly crucial in the context of developmental neurotoxicity, where early exposure to toxicants can have lifelong consequences. This review specifically presents an in-depth overview of the current progress in hiPSC-derived neural models and their applications in neurotoxicity testing, with a specific focus on their utility in assessing pesticide-induced neurotoxicity. Emphasizing future research priorities, we highlight the potential of these models to transform predictive toxicology, offering more human-relevant assessments and advancing the field toward a more precise evaluation of environmental neurotoxicants.

Several methods were developed in lab work, including forensic analysis of polymers & organic GSR from 3D printed firearms using Direct Analysis in Real Time Mass Spectrometry (DART-MS) for a wide variety of applications. Since its introduction, DART-MS has been studied for forensic use in areas including drug detection, gunshot residue, printer inks, and even insect identification. We used DART-MS to characterize the polymer evidence left behind by a 3D-printed firearm on cartridge cases, bullets, and the receiving surface. According to James Cizdziel, “There is concern with these 3D printed guns because they have no serial numbers. The fire gun barrels made with Acrylonitrile Butadiene Styrene (ABS), Polylactic Acid, PETG, Chlorinated Polyethylene (CPE) & Nylon were examined by DART-MS. The resulting cartridge cases, bullets & GSR are examined by Direct Analysis of Real Time-Mass Spectrometry”. It successfully detects and identifies the traces of polymer and organic GSR compounds on the bullets, cartridge cases, and in GSR collected from clothing. While detecting polymer in the trace evidence was challenging, DART-MS obtained clear spectra that matched the plastic from the gun from clothing used as a backdrop for test fire. According to the study, DART-MS readily detected three chemicals commonly found in firearm propellants (ethyl centralite, methyl centralite, and diphenylamine) on the bullet and cartridge case, as well as in the solvent wash of the GSR stub. The resulting cartridge cases, bullets, and gunshot residue (GSR) were examined by direct analysis in real time – mass spectrometry (DART-MS). High-resolution mass spectra detected polymer from the gun barrel on bullets and cartridge casings for a 0.38 special Caliber gun and, to a lesser extent, for a 0.22 Caliber 3D-printed gun. This study states that analysis of firearm trace evidence using DART-MS needs more attention & that the technique may be particularly useful for investigating crimes involving 3D-printed guns. I'm writing my review paper on this topic because it's important for addressing challenges related to 3D-printed firearms. These weapons often don't have traditional serial numbers, making them difficult to trace. However, by analyzing polymer residues left on bullets, cartridge cases, or nearby surfaces, investigators can potentially identify the firearm used. The unique chemical makeup of polymers used in 3D printing can help ink the residue back to a specific gun or even a particular 3D printer model. This study states that analysis of firearm trace evidence using DART-MS needs more attention & that the technique may be particularly useful for investigating crimes involving 3D-printed guns.

Emerging evidence indicates that micronutrient deficiency could play a significant role in the pathogenesis and progression of many chronic diseases including diabetes mellitus, hypertension, obesity, dyslipidemia, hyperuricemia, kidney disease, cancer, anemia and other cardio-metabolic and neurodegenerative diseases through the induction of Insulin resistance (IR). However, there are still gaps in our scientific knowledge regarding the links between micronutrient deficiencies, IR, and cardio metabolic disorders. This review provides current information on recent advances and a global perspective regarding the relationship between micronutrient deficiency, IR, and cardio metabolic disorders. Empirical evidence indicates that deficiencies in either micronutrients associated with insulin activity (such as Chromium, manganese, magnesium, and iron) or antioxidant enzyme cofactors (such as vitamin A, copper, zinc, and manganese) could impact several physiological processes leading to a cascade of metabolic and biochemical derangements such as B-cell apoptosis, loss of islet cell mass, defective tyrosine kinase activity, oxidative stress, pancreatic β-cell dysfunction, reduction in lean body mass, defective insulin signaling mechanism, elevated protein kinase C activity, and excess intracellular calcium. Collaboratively, these states of metabolic malfunctioning are associated with IR, which triggers the onset of many cardio metabolic diseases. Undoubtedly, the prevention of micronutrient deficiency may indeed ameliorate the incidence of IR and cardio-metabolic disorders in those at risk and in the general population.

Clarireedia jacksonii sp. nov. Formerly Sclerotinia homoeocarpa F.T. Bennett, the causal agent of dollar spot (DS), is the most destructive pathogen in turfgrass. Symptoms appear as circular patches 10-40 mm in diameter with small tan lesions surrounded by a darker band, sometimes presenting an hour glass appearance. A multi-year study was initiated with the objective of determining the efficacy of biological control agents (BCA) and tank mixes of BCA’s and synthetic fungicides on DS control. Nutrient source was also evaluated to determine any interaction with the BCA’s and tank mixes. in vitro studies evaluated the efficacy of synthetic and BCA’s for C. jacksonii control. Quarter strength potato dextrose agar was amended with ¼, ½ and full labeled rates of various products. Chlorothalonil at all rates provided greatest (> 90%) control of C. jacksonii for study duration. Biological control agents provided best efficacy at ¼ and ½ label rates. Streptomyces griseoviridis provided least efficacy and may have exacerbated formation of C. jacksonii. Preventative field evaluations for synthetic and BCA’s provided different results between two study years. In Year 1, all treatments had < 15% disease severity for the duration of the study. In year 2, disease pressure was extremely elevated. Synthetic program 1, centered on azoxystrobin + propiconazole applications and conventional fertility sources, provided best results with < 5% disease severity for the duration of the study. Reduced synthetic program 1, and synthetic program 2 followed closely with < 10% disease severity. Reduced synthetic programs were based on monthly applications of either chlorothalonil or pyraclostrobin every 30 day, alternated with biofungicide applications. Synthetic program 2 utilized rotation applications of pyraclostrobin and chlorothalonil every 14 days. Organic programs, utilizing only biofungicides and organic fertility sources, provided the least amount of control and exceeded the 15% threshold by the second month of the evaluation period.

The physiological removal of foreign bodies in the horse’s external ear canal is best achieved by head-shaking. However, external otitis in the horse induces moderate to severe pain: therefore, the horse does not shake his head. The causes of external otitis are dust, water in the external ear canal, keratin, and ceruminous debris. The clinical symptoms are ear discharge, skittishness, facial nerve paresis, and/or head tilt. After the horse has been sedated, the most important diagnostic procedure is the endoscopy of the cartilaginous and osseous part of the external ear canal, including the evaluation of the transparency of the tympanic membrane. The clinical complications of external otitis are hearing loss, facial nerve paresis, head tilt, hypertrophy of the tympanostylohyoideum, and corneal ulcers. The most important treatment is soaking up the exudate in the osseous part of the external ear canal using small cotton balls which are held by the foreign body forceps of the endoscope. Based on the results of the culture of exudate and the antibiogram, an antibacterial drug must be administered orally for 3 to 4 weeks. At this time, an endoscopy of the external ear canals and guttural pouches also has to be done. Based on the outcome of the endoscopy, endoscopic and clinical investigations have to be performed six months later as well. Only 7/19 horses had a normal osseous part of the external ear canal with a transparent tympanic membrane, including normal hearing measured by the brainstem auditory-evoked response after one month of treatment.

This study is aimed at investigating the age related changes in postnatal development of red Sokoto goat stomach. In this study, a total of ten red Sokoto goat digestive tract samples were used and they were grouped into five (5) age categories (group A to E). The goat ages were estimated using dentition eruption and wearing. The stomach was identified and separated from the other part of digestive tract. The gross study revealed that the stomach was composed of four (4) segments that named; rumen, reticulum, omasum and abomasum with anatomical demarcations between them. The biometric study of weight, length, width, thickness, and volume was found to be increasing with advancement in postnatal ages with the following valves shows the mean value of weight, length, width, thickness and volume were to be 29 to 58.0 (g), 23.5, to 52.1 (cm), 15.4 to 29.0 (cm), 0.48 to 1.0 (mm) and102 to 432 (cm3) from group A to group E respectively. Based on the above findings it was suggested that more research should be conducted using histological techniques and electron microscopy in order to finalize on the findings.