Bouchoual M*, Dadi K, El Khand A, El Ouazzani M, Anibar S, Jabrane M and Arrayhani M
Published on: 29th January, 2025
Introduction: Membranoproliferative glomerulonephritis (MPGN) is a significant cause of glomerulopathy and chronic kidney disease (CKD) or end-stage renal disease (ESRD) in children. The deposition of circulating immune complexes in the glomerulus and abnormal activation of the alternative complement pathway is believed to trigger the disease. However, there is limited knowledge regarding the optimal treatment and prognosis for children with immune complex-associated MPGN (IC-MPGN) and C3 glomerulopathy (C3G).Case report: We report the case of a 14-year-old child admitted for rapidly progressive glomerulonephritis with anuria managed on haemodialysis. The kidney biopsy showed an appearance compatible with MPGN on light microscopy, with immunoglobulin and complement C3 deposits on direct immunofluorescence. The prognosis was poor, with rapid progression to ESRD despite treatment combining corticosteroid therapy and immunosuppressants.Discussion and conclusion: Evaluating the effectiveness of different therapeutic approaches for MPGN in children is challenging due to the small sample sizes and the short duration of the published controlled studies. As a result, it is crucial to conduct more comprehensive trials that focus on both prognosis and treatment options.
This review gives a brief introduction to the microarray technology and its experimental design and data analysis and a discussion of recent global progress in research using microarray technology in fish biology and aquaculture. DNA microarrays have been reported to have been used for the analysis of gene expression during various physiological, developmental or cellular processes in fish. During the recent past, investigators have begun to use microarrays on fish to address ecological, evolutionary and environmental questions including the variability of gene expression in natural populations, speciation, ecotype diversity, environmental remediation and host-pathogen interactions. The study suggests that a lot of gene expression studies have been conducted on salmon and zebrafish in Europe and USA. The same may be applied on Indian Major Carps and Catfishes to augment productivity from aquaculture sector.
ATPases is known to be a crucial in many biological activities of organisms. In this study, physicochemical properties and modeling of ATPases protein of fish was analysed using In silico approach. ATPases a protein selected from fish species, including Gold fish (Carassius auratus auratus), Zebra fish (Hypancistrus zebra), White fishes (Coregonus autumnalis), Grass carp (Ctenopharyngodon idella) and Anabas testudineus (Koi) were used in this study. Physicochemical characteristics showed with molecular weight (25045.58-25148.57Da), theoretical isoelectric point (9.30-9.97), extinction coefficient(26470-34950), aliphatic index(147.31-150.35), instability index(32.84-42.67), total number of negatively charged residues and positively charged residues (5/7-6/8), and grand average of hydropathicity (1.014-1.151) were computed. All proteins were classified as transmembrane proteins. In secondary structure prediction, all proteins were composed of random coils as predominant, followed by extended strands, alpha helix and beta turn. Three dimensional structure of protein were predicted and verified as good structures. All model structures were evaluated being accepted and reliable based on structural evaluation and stereo chemical analysis.
In sports medicine, the recovery process for injuries to the musculoskeletal system has been well established, including the recovery time until the athlete can compete again to prevent relapses. These decisions support the sports physician in acting with greater confidence. However, there are no clear criteria and protocols for other systemic diseases. In the following study, we report our experience and suggest an action protocol for a professional basketball team.
Scoliosis is a condition of abnormal lateral curvature of the spinal column greater than 10 degrees as measured by Cobb’s angle. The two main groups of scoliosis are idiopathic scoliosis and non-idiopathic scoliosis. The diagnosis of an idiopathic scoliosis is made if a non-idiopathic one has been excluded. Idiopathic adolescent scoliosis is a more common form. Neuromuscular scoliosis, which is a type of non-idiopathic scoliosis, is characterized by diverse muscular and neurological impairments. Anesthesia and surgery for neuromuscular scoliosis have a higher risk of perioperative complications than for idiopathic cases.
This editorial explores the crucial yet often overlooked role of sleep in enhancing student-athlete performance and well-being. It highlights sleep’s impact on physical recovery, cognitive function, and emotional stability, emphasizing the unique benefits for athletes. The editorial examines the detrimental effects of early school start times on adolescent sleep patterns and their subsequent impact on academic and athletic performance. By advocating for policy changes that prioritize sleep, such as delaying school start times, this editorial presents a novel approach to optimizing student-athlete success. Through a synthesis of current research and practical insights, it urges stakeholders in education and sports to recognize and act upon the foundational importance of sleep, positioning it as a key component of athletic and academic excellence.
Yassine Haimeur*, Mouhssine Doumiri and Mourad Amor
Published on: 15th May, 2025
Cerebral Autoregulation (CA)-directed therapy, or optimal cerebral perfusion pressure (CPPopt)-targeted therapy, is a tailored bedside method of resuscitation used in critical care that aims to achieve and maintain the CPPopt, to fit the precise cerebral hemodynamics and metabolic demand. Different processes and multiple tools are available to conduct a CA-directed therapy in acute brain-damaged adult admitted into critical care settings, but literature is limited and primarily focused on traumatic brain injury; however, for other brain conditions. By this scope review, we aim to describe the main procedures used by authors to achieve a CA-directed therapy, as well as its acquisition methods and its usefulness in acute non-traumatic brain-damaged adult in neurocritical care.
Matilde Valencia-Flores*, Victoria Santiago-Ayala, Margarita Fernández López, Jorge Oseguera Moguel, Gerardo Payró Ramirez, Montserrat Reséndiz-Garcia, Montserrat Memetla-Argumedo, Gabriela Gaytán-Cervantes, Ramón Morales-Navarro, Carlos A. Aguilar-Salinas and Donald L. Bliwise
Published on: 15th May, 2025
Background: Absence of nocturnal decrease in Blood Pressure (BP) (“non-dipping”) has been shown to be a strong and independent predictor of cardiovascular events, target organ damage, cardiovascular sequela and cardiovascular mortality. Obstructive Sleep Apnea (OSA) has been associated with non-dipping with an estimated prevalence of approximately 50%, but factors associated with non-dipping in OSA patients remain poorly understood. In this study, we examined clinically relevant variables associated with non-dipping in OSA.Methods: Patients (n = 35) undergoing overnight valuation for OSA, laboratory-based polysomnography, structured clinical interviews, and comprehensive metabolic and anthropometric evaluations, and ambulatory BP monitoring for 24 hours. Patients were classified into a) dipping BP group or b) non-dipping BP group, based on (a) a nocturnal systolic BP decrease of 10% - 20% or (b) a systolic BP decrease of < 10%. Results: Patients had moderate and severe OSA (AHI = 34.8 ± 29.1), and 42.9% demonstrated a non-dipping BP pattern. The severity of OSA measures did not differ between dipping group and non-dipping group. However, Wake after Sleep Onset (WASO) and chronicity of insomnia predicts non-dipping BP independent of demographics, sleep stages, anthropometrics, metabolic measures, or arterial stiffness. Conclusion: These findings contribute to a better understanding of the cardiovascular impacts of OSA and indicate that sleep quality should be incorporated into clinical assessments and management of OSA patients.
Siddharth Agarwal*, Sapna Agarwal and Shreyash Dayal
Published on: 22nd May, 2025
This study explores the effectiveness of Homeopathy in managing infectious diseases, focusing on its integration with nanoscience. The key objectives include assessing the role of homoeopathic treatments in reducing morbidity and mortality from various infections, such as respiratory, gastrointestinal, and mosquito-borne diseases, and examining the scientific mechanisms behind its therapeutic effects.Key findings from the study include evidence of nanoparticles in highly diluted homoeopathic solutions, suggesting that these remedies may retain measurable amounts of the original substances. This nanoparticulate perspective bridges traditional homoeopathic practices with modern nanomedicine. Historical evidence, such as Hahnemann’s work on scarlet fever and recent studies during the 2006 Chikungunya epidemic, supports the effectiveness of homoeopathic treatments, demonstrating improved recovery rates and reduced complications with integrated homoeopathic and allopathic approaches.The main conclusion of the study is that Homeopathy, particularly when combined with nanoscience, holds significant promise as a complementary approach in the management of infectious diseases. The presence of nanoparticles in homoeopathic remedies may explain their therapeutic effects, positioning Homeopathy as a valuable component of holistic healthcare strategies, especially in developing countries.
Aim: To compare the vision related quality of life before and after prescription of refractive glasses in school-aged children. Design: A prospective, comparative, and hospital-based interventional study was conducted at the Regional Institute of Ophthalmology, PGIMS, Rohtak between May 2021-May 2022. It involved assessment of vision-related quality of life (VRQoL) in 200 school-going children of the 5-16 age group, then comparing outcomes in children with URE versus those corrected with eyeglasses. Those with significantly low visual acuity (≤ 6/9) on Snellen’s were enrolled in the study after obtaining written informed consent from parents. The Modified SREEQ was used to assess VRQoL. Various parameters of comparison included age, gender, demography, education, and improvement in VRQoL within individual study groups over time. Comparison was done before and after using prescription refractive eyeglasses with a follow-up period of 3 months. Results: The correction amongst hypermetropes, 40 out of total 200 students (20%), correction among myopes (153 of 200 students), correction amongst students with astigmatism (7 out of 200 students) resulted in changing categories from mild/moderate/severe visual impairment to normal category of visual acuity i.e., 6/6 on immediate correction with refractive glasses prescribed to them post refraction. Students with astigmatism showed an improvement in symptoms like distorted images post-refractive correction at 3 months. Thus, proving a positive role of refractive eyeglasses in reducing the burden of refractive errors in our study population and improving the visual outcome. Conclusion: VRQoL was better in students after they got their refractive errors corrected with prescription eyeglasses at 3 months as compared to their QoL evaluated at their first visit to our centre with URE. This study focused on having a holistic approach towards improvement in QoL by taking into consideration the academic, psychological, cost-effectiveness aspects of VRQoL among students in the age group 5-16 years old.
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