Free Radicals, Antioxidants and Redox Potential
Published on: 29th May, 2025
The role of free radicals and antioxidants is often underestimated despite their involvement in key metabolic processes, although they participate in many important metabolic processes in the life of humans, animals and plants. Their quantity and quality differ from each other, which is not respected. Each cell is attacked approximately 10,000 times by free radicals. Oxidative stress is the cause of many problems, especially in viral diseases. Monitoring of redox potentials in body fluids is usually not carried out. Viral replication is influenced by oxidative energy, derived from either host metabolism or free radical activity, which is supplied by oxidation by free radicals or the host. Nucleic acid mutations due to the effect of free radicals can be the cause of carcinomas, and possible defense against mutations could help eradicate dangerous viruses. The importance of malondialdehyde and antibodies against it is discussed. Eliminating free radicals, reducing lipoperoxidation, and protecting against environmental oxidative stress are important factors for human health.Study objective: To highlight the importance of free radicals, antioxidants and redox potentials for patient diagnosis and therapy.Methods: This study synthesizes findings from multiple published sources, including our own research.Results: Findings highlight the role of free radicals in oxidative stress, DNA damage, and viral replication, with redox potential (ORP) and Malondialdehyde (MDA) identified as key diagnostic markers.Conclusion: Monitoring oxidative balance and targeting free radical activity are essential for preventing cellular damage and improving clinical outcomes in oxidative stress-related diseases.
Microscopic Diagnostics and Mapping of Cytophysiological Effects of Reactive Oxygen Species during Microwave Exposure of Living Tissues
Published on: 30th May, 2025
A specialized installation has been developed for microscopic study of the Reactive Oxygen Species (ROS) formation during microwave irradiation of biological samples with automated control / mechanized tube and real-time data acquisition. The above installation can be used in biomedical practice for: standardization or certification of the microwave sources; testing of the potential antioxidants that protect tissues from ROS-induced effects; testing fluorescent sensors for ROS; analysis of ROS localization and distribution in various tissues in order to establish specific pharmaco-physiotherapeutic and toxicological localizations of ROS in different topographic-anatomical zones. The paper pays special attention to the singlet oxygen produced by the samples upon microwave treatment, as a physiologically active and highly reactive agent.
Pulmonary Pleomorphic Carcinoma: A Rare Entity Revisited!
Published on: 4th June, 2025
Introduction: Pleomorphic Carcinoma (PC) is a subset of poorly differentiated non–small cell lung cancer that is diagnostically challenging because it is a rare malignancy of the lung. It shows varying dual-cell components; spindle or giant cells and epithelial cells.Method: We report a case of 68-year-old non-smoking female who presented with cough, fever, pain in the left side of chest & weight loss of recent onset and an abnormal shadow on her chest X-ray. Computed tomography of chest revealed a well defined heterogeneously enhancing cavitatory soft tissue lesion in the posterior basal segment of the left lower lobe with mediastinal lymphadenopathy.Results: Fine needle aspiration cytology& percutaneous lung biopsy confirmed poorly differentiated malignant tumor. Patient underwent a left lower lobectomy. A diagnosis of PC was confirmed after Immunohistochemistry (IHC). Mutation analysis revealed an EGFR exon 21 mutation within the tumor cells. The patient is on Gefitinib based chemotherapy and has remained disease-free for three years post-surgery.Conclusion: PC of the lung is a rare pathological entity. Definite diagnosis may only be made on a resected tumor along with the use of IHC. Surgical resection is the main modality of the treatment. Such rare cases should be documented to establish an optimal management plan and to provide a further insight to targeted therapy.
Evaluation of Long-term Antithrombotic Management for Atrial Fibrillation Patients with a History of Coronary Stent Implantation
Published on: 12th September, 2024
Purpose: American expert consensus publications recommend discontinuation of antiplatelet agents 6 to 12 months after Percutaneous Coronary Intervention (PCI) in patients with Atrial Fibrillation (AF) who require chronic anticoagulation, and use of oral anticoagulant monotherapy thereafter. This study aimed to assess real-world long-term antithrombotic therapy management practices and factors associated with the continuation of antiplatelet agents past 12 months post-PCI in patients with AF requiring chronic anticoagulation. Methods: Patients with AF and a history of PCI greater than 12 months before their most recent encounter with physicians at an outpatient electrophysiology clinic were identified by chart review. Patient demographics, clinical characteristics, and current antithrombotic regimen were collected from encounters that occurred between July 2019 and June 2022. The independent predictive factors associated with the continuation of antiplatelet agents were identified using univariate and regression analyses. Results: Out of 66 patients, 67% continued antiplatelet therapy for greater than 12 months post-PCI. Patients on antiplatelets were significantly less likely to have bare metal stents (p = 0.006), be greater than five years post-PCI (p = 0.002), and have a HASBLED score of two or less (p = 0.028) when compared to patients on oral anticoagulant monotherapy. Bare metal stent history (p = 0.045) and HASBLED score of two or less (p = 0.016) were also significant in regression analysis.Conclusion: This study found that most patients with AF and a history of PCI continued antiplatelet therapy longer than 12 months post-PCI, often despite the high bleeding risk.
Aplastic Anemia Induced by Parvovirus B19 Infection in an Immunocompetent Adult: A Case Report and Literature Review
Published on: 12th June, 2025
A 24-year-old male presented with epistaxis and gingival bleeding, physical examination revealed pallor and purpuric spots on the left upper limb. Laboratory findings showed pancytopenia. As part of the etiological workup for pancytopenia, a bone marrow aspirate was performed, revealing moderately cellular marrow with rare megakaryocytes and intranuclear inclusions in proerythroblasts. Parvovirus B19 testing in the bone marrow was conducted via nucleic acid extraction followed by PCR.
Medicolegal Aspects of Deaths Due to Poisoning Occurred In Cities of Punjab and the State Of Himachal Pradesh
Published on: 17th June, 2025
A poison is a substance capable of causing illness or harm to a living organism upon contact or introduction to the body. Toxins and venoms are poisons of biological origin, with the latter usually reserved to describe the bites or stings of poisonous animals. In India, the suicide rate is 18.5 suicide deaths for every 100,000 people. The majority (79%) of suicides occur in low- and middle-income countries. Ingestion of poison is one of the most common modes of suicide in low and middle-income countries such as India [1].
Neurovascular Shifts, Sensory Sensitivity, and PMDD in Autistic Women: Exploring Blood Flow Redirection, Mood Dysregulation, and Pain Tolerance during Menstruation
Published on: 30th September, 2024
This article examines the relationship between Premenstrual Dysphoric Disorder (PMDD), neurovascular dynamics, and sensory sensitivities in autistic women during menstruation. The redirection of blood flow to the uterus during the menstrual cycle has been found to exacerbate cerebral perfusion deficits in neurodivergent individuals, particularly in the Prefrontal Cortex (PFC), which contributes to the mood dysregulation and emotional instability characteristic of PMDD. Autistic women, who often exhibit heightened sensory sensitivities, experience intensified discomfort during menstruation, as sensory overload and altered pain perception compound the emotional challenges of PMDD. These findings emphasize the need for neurodivergent-friendly menstrual products that mitigate both physical and emotional discomfort. Additionally, innovations using biodegradable materials, smart fabrics, and custom-fit menstrual solutions are discussed as potential breakthroughs to improve the quality of life for autistic women managing PMDD. This research highlights the importance of addressing both neurobiological and sensory aspects when designing interventions for PMDD in neurodivergent populations.
Eyes and Minds under Siege: How Digital Exposure Is Threatening Ocular and Neural Health in Adolescents
Published on: 11th July, 2025
Comparison of Rhodium, Vanadium, Cobalt, Inconel & Silver Emitter Self-Powered Neutron Detectors: Literature Review Article
Published on: 7th October, 2024
Self-Powered Neutron Detectors (SPNDs) are in use as in-core Neutron Fluence Detectors in Nuclear Power Plants. Though the detectors are simple in design and have a common structure for the same application, there are various types of emitters (neutron-sensitive electrodes) that make SPNDs categorized into different types. There are various SPNDs in application at different types of nuclear power reactors. SPND emitters are chosen based on their characteristics/behavior in the neutron & gamma flux environment in the reactor core. A detailed Literature Review was done on five different types of SPNDs. This paper focuses on the physics behind the operation, characteristics, and review of Vanadium, Rhodium, Inconel, and Cobalt & Silver emitter-based SPNDs. A comparison study was done by a literature review on these detectors.
Evaluation of the Clinical Rationality of the use of Cefazoxime Sodium for Injection in 328 Cases
Published on: 18th July, 2025
Objective: To study the use of cefazoxime sodium for injection in inpatients of the Third People’s Hospital of Yancheng City, and to provide reference for the rational clinical use of cefazoxime sodium. Methods: A retrospective study method was used to retrieve the medical records of patients discharged from 2 departments of urology and general surgery of the hospital using cefazoxime sodium in June-August 2023, and the rationality of the clinical use of injectable cefazoxime sodium was evaluated with reference to the relevant standards. Results: A total of 328 valid cases were included, of which 6 cases did not meet the dosage criteria, 10 cases did not meet the treatment time criteria; 44 cases did not meet the indication criteria. The comprehensive judgement of the reasonableness of the clinical use of cefazoxime sodium for injection resulted in 272 cases of reasonable use of the drug; 56 cases of unreasonable use of the drug. Conclusion: The clinical use of cefazoxime sodium for injection in this hospital is irrational and needs to be further strengthened and corrected.
Search by University/Institution
Enter your University/Institution to find colleagues at HSPI.
Ensuring author's satisfaction with
- Friendly and hassle-free publication process
- Less production time of articles
- Constructive peer-review
- Enhancing journal reputation
- Regular feedback system
- Quick response to authors' queries
Most Viewed Keywords
- Cissus quadrangularis
- Prostate cancer
- Computed tomography
- Serum uric acid
- Immune system
- Forensic science
- Osteopoikilosis
- Parkinson’s disease
- Valves in valves
- Oxidative stress
- Dry Powder Inhaler, Inhalation Technique, Patients with COPD, Rotahaler
- Cadmium
- Conization
- Liver
- Free radicals
- Patients
- Plant health
- Lung cancer
- Nephrotic syndrome
- Dietary supplements
Search Articles by Country
Get all latest articles in all Heighten Science Publications Inc journals by country.
Testmonials
I am delighted and satisfied with. Heighten Science Publications as my manuscript was thoroughly assessed and published on time without delay. Keep up the good work.
Ido-Ekiti/Afe Babalola University, Nigeria
Dr. Shuaib Kayode Aremu
Dear colleagues! I am satisfied with our cooperation with you. Your service is at a high level. I hope for a future relationship. Let me know if I can get a paper version of the magazine with my artic...
Aksenov V.V
Your service is very good and fast reply, also your service understand our situation and support us to publication our articles.
Ayman M Abu Mustafa
Publishing with the International Journal of Clinical and Experimental Ophthalmology was a rewarding experience as review process was thorough and brisk. Their visibility online is second to none as t...
University of Port Harcourt Teaching Hospital, Nig...
Dr. Elizabeth A Awoyesuku
I wanna to thank Clinical Journal of Nursing Care and Practice for its effort to review and publish my manuscript. This is reputable journal. Thank you!
Atsedemariam Andualem
''Co-operation of Archives of Surgery and Clinical Research journal is appreciable. I'm impressed at the promptness of the publishing staff and the professionalism displayed. Thank you very much for y...
Anıl Gokce
Your journal co-operation is very appreciable and motivational. I am really thankful to your journal and team members for the motivation and collaboration to publish my work.
Assistant Professor, UCLAS Uttaranchal University,...
Archna Dhasmana
Archives of Vascular Medicine is one of the top class journal for vascular medicine with highly interesting topics. You did a professional and great Job!
Elias Noory
It has been a fabulous journey writing articles for your journal because of the encouragement you people provide for writers from developing nations like India. Kindly continue the same. Looking forwa...
Badareesh Lakshminarayana
To the editorial team at HSPI and the Journal of Clinical Nephrology: Thank you so much for your hard work and collaboration in bringing our article to life. Your staff was responsive, flexible, and ...