“Fatty Lungs”: An uncommon case of Autoimmune Pulmonary Alveolar Proteinosis
Published on: 5th August, 2021
OCLC Number/Unique Identifier: 9157841457
Pulmonary Alveolar Proteinosis (PAP) is a rare lung disease characterized by excessive accumulation of surfactant lipids and proteins in alveoli and terminal airways. It is caused by impaired GM-CSF signaling [1]. Surfactant is synthesized and secreted by alveolar type II epithelial cells, and removed by uptake and catabolism by these cells, and the alveolar macrophages. Patients with PAP usually describe gradual onset of progressive exertional dyspnea and non-productive cough. However, an asymptomatic presentation is observed in up to 25% of cases, even in the presence of diffuse radiographic changes. Three recognized subtypes exist. Autoimmune PAP is associated with neutralizing GM-CSF autoantibodies and accounts about 90% of cases. Secondary PAP may occur in the context of any disease that reduces the abundance or functionality of alveolar macrophages, resulting in impaired surfactant clearance. Congenital PAP is the result of genetic mutations that disrupt GM-CSF signaling, including mutations in the α- or β-chains of the GM-CSF receptor [1-3].
Scientific Analysis of Eucharistic Miracles: Importance of a Standardization in Evaluation
Published on: 13th November, 2024
Numerous instances of consecrated communion wafers turning into human tissue and blood have been reported throughout history and the contemporary international media, referred to as Eucharistic miracles. Various suggestions have been put forth to explain such phenomena, ranging from miraculous to natural. Here, a novel demonstration is provided showing that the appearance of a bleeding host can occur by placing ordinary, non-consecrated wafers under similar conditions as described for many of these events. Using basic forensic methods, distinctions between ensuant reddish areas and genuine blood were noted. In previous studies with miracle wafers, isolated DNA was resistant to amplification with human-specific primers, which has been attributed to its divine nature. The current study shows that multiple types of non-human DNA existed in unconsecrated wafers, providing an alternative explanation for such findings. Finally, a minimal protocol of scientific examination is outlined to aid in the standardization of such investigations in the future, including a distinctive approach to authenticate the genuine shared origin of such occurrences.
Dalbavancin and moleculight in the COVID-19 pandemic
Published on: 11th April, 2023
The COVID-19 Pandemic, which began in March 2020, and its associated surges, had an immense impact on our medical staff and their ability to perform their daily duties.The COVID-19 Pandemic necessitated hospital modifications, including the expansion of the Emergency Department, ICU, and Isolation units. The overwhelmed staff and overburdened ER and ICU required adjustments to deal with the Inpatient impasse. For example, temporary patient care rooms needed to be set up for the overflow of patients. The tsunami of the Pandemic almost overwhelmed our hospital.With the challenges presented to our hospital during the Pandemic, we needed a fresh perspective to our multi-disciplinary approach. Thus, we fathomed that the use and cost-effectiveness of both Dalbavancin, a long-acting lipoglycopeptide antibiotic combined with the diagnostic Moleculight Imaging Device would be a sound decision.We hypothesized that with the use of this cost-effective antibiotic in conjunction with the use of the Moleculight Imaging Device, with its fluorescent imaging, we could detect the presence of bacteria and assist our wound treatment and decision-making.A shift in patients from the Emergency Room/Inpatient Department to the Outpatient Department/Wound Care Center was made possible with the use of these two novel products.
The Effectiveness of Honey-Based Ferric Perchloride Paste on Post-conization in the Cicatricial and Infectious Context: A Randomized Clinical Trial
Published on: 7th November, 2023
Introduction: The skills, the techniques utilized in the conization and the hemostasis directly affect the healing process of the cervix tissue. Excessively large excisions and unnecessary use of electrocautery or hemostatic sutures are examples of procedures that may negatively affect the scar cascade and wound healing. Objective: The purpose of this study was to examine the effectiveness of honey-based ferric perchloride paste (HBFPP) in reducing bleeding and infection post-conization procedure. Methods: Prospective randomized clinical trial with a sample of 142 patients randomized in two groups: 78 patients who used the HBFPP (intervention) and 64 patients who did not use the HBFPP (control). Statistical analysis was performed utilizing a significance level of 95%. The Chi-Square test and Fisher’s exact test were applied. Results: Results showed that the mean score of the amount of blood lost was lower in the intervention group compared to the control group. The main complaints reported by the two groups in the postoperative period were discomfort in the genitourinary system, heavy bleeding after surgery, and post-operative infection, but not significantly different among both groups. The control group needed further intervention due to excessive bleeding in comparison with the intervention group. Conclusion: The use of HBFPP reduced the amount of blood lost in the postoperative period of conization surgery.
Non-invasive physical plasma as an innovative physical approach for the oncological therapy of skeletal sarcomas
Published on: 21st September, 2022
Human osteosarcoma is the most common malignant bone tumor with an annual incidence of two cases per 1 million population. Osteosarcoma account for 60% of all malignant bone tumors occurring in childhood, followed by Ewing’s sarcoma [1-3]
Painful unilateral gynecomastia with identification of the cause of the pain: A case report
Published on: 31st December, 2021
OCLC Number/Unique Identifier: 9382574194
A 69-year-old man presented with a one-month history of a painful mass in the right breast. Pathologic evaluation of the excision of the mass revealed a proliferation of both glandular and stromal elements consistent with gynecomastia. In addition, histologic examination revealed peripheral nerves in the deep portion of the specimen were entrapped in the proliferative changes associated with gynecomastia. It is proposed that the expansile proliferation led to compressive pressure on the nerves and caused the pain associated with gynecomastia.
Challenges of Novice Nurse Educators’ Transition from Clinical Practice to Academia in Ghana: A Qualitative Study
Published on: 27th November, 2023
Background: The recruitment of experienced clinical nurses into vacant faculty positions is a global strategy for preparing, employing, and retaining competent nurse educators. As clinical nurses transition to academia, many struggle with unique challenges that affect their adaptation to the academic setting. Thus, understanding novice nurse educators’ transitional challenges is critical to addressing this threat. Aim: This study aimed to explore the challenges of novice nurse educators’ transition from clinical practice to academia in Ghana. Methods: A descriptive qualitative study design was employed for this study. A purposive sampling technique was used to recruit 12 novice nurse educators from three health training institutions in the Upper East Region of Ghana. A semi-structured interview guide was used to collect data through in-depth individual interviews. The interviews were audio-recorded, transcribed verbatim, and thematically analyzed.Results: Four themes emerged: poor administrative support, poor preparation, increased workload and stress, and role ambiguity. Novice nurse educators lacked formal orientation, formal mentorship, formal education in teaching, and post-graduate education. Novices were also challenged by increased workload and role ambiguity. Conclusion: Supporting novice nurse educators' transition from clinical practice would be better served by college administrators’ creation and implementation of formal orientation and mentorship programs.
The role of islamic lifestyle and healthy nutrition in accordance with the recommendations of islam and the holly quran by focusing on the risk of cancer incident
Published on: 17th November, 2020
OCLC Number/Unique Identifier: 8872660064
Background: The Islamic religion has emphasized the importance of health and well-being, and Muslims have recognized the value of a good and healthy life based on Islamic recommendations. Health-oriented lifestyle is a multi-dimensional phenomenon that is the purpose of this study to investigate the Islamic lifestyle.
Methods: In this review study, we tried to explore practical strategies in Islam through access to credible sources in the form of a descriptive article on achieving a healthy lifestyle in nutrition. For this purpose, using keywords and electronic and manual searches in authentic Islamic and medical sources, information was searched and collected to answer the research question.
Results: Based on the results of the reviewed studies, the guidelines of Islamic religion and beliefs are mainly based on improving lifestyle factors and dietary habits. It has been emphasized that adherence to the Islamic dietary guidelines and lifestyle, may lead to less risk of diseases.
Conclusion: Given the availability of valuable nutritional resources and instructions in Islam to prevent and combat nutrition-related diseases, these theories can be applied and prevent from spreading and creating malnutrition-related diseases; the guidelines of Islam on healthy lifestyles in nutrition can be recommended to the world as a basic strategy
Micropropagation and cytological studies of Aole vera Linn
Published on: 30th September, 2022
OCLC Number/Unique Identifier: 9636718751
Aloe vera Linn. is an essential medicinal plant. In this present research work, a protocol of in vitro regeneration and karyomorphological analysis of Aloe vera was developed using different concentrations and compositions of media. Shoot apices of field-grown plants were used as explant and aseptically cultured on Murashige and Skoog (MS) medium fortified with different concentrations and combinations of auxins (IAA and NAA) and cytokinins (BAP and Kn). The highest number of multiple shoot buds (4.36 ± 0.07) was obtained from MS + 2.0 mg/l BAP + 1.0 mg/l IAA and induced shoot buds underwent rapid elongation (4.24 ± 0.06 cm) on the same medium composition. Half strength MS media with 2.0 mg/l IBA was suitable for induction and proliferation (6.31 ± 0.05) of roots and 95% of plantlets were acclimatized to field conditions successfully. Somatic chromosome numbers of mother and in vitro grown plants were confirmed to be 2n = 14. Chromosome length ranged from 4.28 - 13.74 µm in the naturally grown plants and 4.46 - 14.1 µm for in vitro grown plants. The total form percent (TF%) of mother and in vitro grown plants was 41.69% and 42.23%, respectively. The karyotype formula of in vivo grown plants was 2n = 14 = 4Lsm + 6Mm + 4Sm, whereas that of the micropropagated plants was 2n = 14 = 4Lsm + 4Mm + 6Sm. The frequency of the chromosome having arm more than 2:1 was 0.08 for mother plants and 0.15 for in vitro grown plants. Therefore, the karyotype of both plants falls into the 2B symmetrical type based on Stebbins classification (1971).
Particularities of COVID-19 infection in chronic hemodialysis patients in Sub-Saharan Africa: experience from Senegal (West Africa)
Published on: 23rd May, 2023
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appeared in December 2019 in China and has rapidly become a major global health concern. Patients with end-stage renal disease receiving dialysis treatment are very exposed to the SARS-CoV-2 during their frequent visits to healthcare facilities and immune induced by uremia. The aim of our work was to describe the particularity of COVID-19 infection in hemodialysis patients in sub-Saharan Africa and in Ziguinchor, south of Senegal, particularly. To do this, we conducted a monocentric prospective study over a period of 16 months at the Ziguinchor hemodialysis center and compared our results to a study that focuses on the seroprevalence of SARS-CoV-2 in chronic hemodialysis patients. We found a low prevalence of COVID-19 infection while the majority of our patients were in contact with the virus.
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