Squamous Cell Carcinoma of the External Auditory Canal in Previously Treated Case of Adenoid Cystic Carcinoma of Parotid Gland
Published on: 1st May, 2025
Malignant neoplasms of the external auditory canal, middle and inner ear are rare. This anatomically complex region generates complicated three-dimensional specimens that can be a challenge for macroscopic and microscopic assessment [1]. The most common cause of malignancy involving the EAC and temporal bone is extension of cutaneous malignancy of pinna. Rare occurrences have been described in association with CSOM and sporadic cases arising in previously irradiated fields for the treatment of other head and neck cancers. The tissue diagnosis is relatively straightforward; however staging is a complex task that is best approached with consideration of clinical, radiological, and pathological findings [2].
Investigation of Bronchoscopy Associated Pseudo-infections
Published on: 6th May, 2025
Introduction: Bronchoscopy could lead to local spread of pre-existing infection, spread of infection from one patient to another if the bronchoscope is disinfected inadequately, or, isolation of microorganisms from bronchoscopic specimens in a patient who is clinically not infected, i.e., pseudo-infection. This study is one such investigation of an outbreak of bronchoscopic pseudo-infections in a tertiary care hospital.Materials and methods: Bronchoalveolar lavage (BAL) samples were inoculated onto MacConkey Agar and 5% Sheep Blood Agar and incubated at 37 °C overnight. The growths obtained on culture media were processed for identification and antimicrobial susceptibility on Vitek 2 Compact as per manufacturer’s instructions. To investigate the outbreak, 5 mL - 10 mL of sterile water was flushed through the channels of disinfected bronchoscope and collected in a sterile container. The samples were centrifuged and inoculated onto MacConkey Agar and 5% Sheep Blood Agar. The growths obtained were further processed similarly as the BAL samples were processed. Environmental swabs collected from the bronchoscopy unit were also processed as the procedure mentioned above.Results: Bronchoalveolar lavage of 3 patients in a period of 1 week were contaminated with multidrug resistant Klebsiella pneumoniae. Two out of five bronchoscope fluid samples were also contaminated with Klebsiella pneumoniae. Among the swabs collected from bronchoscope unit, Klebsiella pneumoniae was isolated from the detergent box of the endowasher. Conclusion: The risk of propagation of infection via a bronchoscope can be evaded by proper reprocessing and improving the sterilization practices.
Post-COVID Pulmonary Fibrosis: Pathophysiological Mechanisms, Diagnostic Tools, and Emerging Therapies
Published on: 9th May, 2025
OCLC Number/Unique Identifier: COVID-19; Pulmonary fibrosis; Antifibrotics; Lung
Post-COVID pulmonary fibrosis has emerged as a significant long-term complication among survivors of severe SARS-CoV-2 infection. This review highlights the underlying pathophysiology, diagnostic modalities, and recent advances in the diagnosis and management of post-COVID pulmonary fibrosis. As global cases of COVID-19 continue to evolve, understanding and addressing this emerging chronic respiratory condition is critical for long-term patient care.
Computational Simulation of Phase-Molecular Separation-DNA/RNA-Related Function Based on Gene Ontology using Combination of Computational Fluid Dynamics, Machine Learning and Membrane Systems
Published on: 21st May, 2025
Our evaluation and its outcomes/outcomes/hints spotlight that gaining a (having to do with measuring matters with numbers) knowledge of the proteome company in living cells, and its outcomes/consequences/tips for the (introduction and production/ organization of objects) of condensates and MLOs, is a critical assignment that the section separation field wishes to face/address. Our findings that dosage-sensitive (tiny chemical meeting commands interior of living things), insufficient (tiny chemical meeting commands internal of living things) and homologs especially, are overrepresented amongst human LLPS drivers, spotlight furthermore the needed component of preserving the mobile (oversupply/huge quantity) of the (bearing on everyone or issue) DNA/RNA merchandise at a great degree well suited with tightly managed LLPS conduct, to keep away from extreme (diseases/the have a look at of diseases) that unexpected errors in any direction may also cause. In-depth close interest of the records on DNA/RNA concentrations used in the LLPS experiments assisting our excessive self-belief dataset of human driver DNA/RNA s laid the uncertainties related with defining the frame-shape-related meaningful ranges of this essential restriction/guiding principle that leads and controls condensate (introduction and production/ organization of items), and recommended how those uncertainties can be lessened (something awful) and (ultimately) shortened.Graphical abstract: Computational Simulation of Phase-Molecular Separation-DNA/RNA-Related Function Based on Gene Ontology Using Combination of Computational Fluid Dynamics, Machine Learning and Membrane Systems.
Redefining Biotechnology for the Global South: The Role of Synthetic Biology and Computational Tools
Published on: 26th May, 2025
Biotechnology has always played an important role in tackling global concerns, particularly in the Global South, where socioeconomic gaps sometimes stymie scientific progress. Recent advances in synthetic biology and computational technologies have the potential to revolutionize biotechnology in these locations. Synthetic biology allows for the creation and manipulation of biological systems, with promise applications in healthcare, agriculture, and environmental control. Computational methods such as machine learning and artificial intelligence help to optimize synthetic biology processes, enabling innovations that are suited to local requirements. The combination of these cutting-edge technologies with traditional biotechnological techniques has the potential to dramatically improve the Global South's ability to solve issues such as disease outbreaks, food security, and sustainable development. This abstract outline the critical intersections of synthetic biology and computational advancements and their potential to empower the Global South, highlighting the need for supportive policies and capacity-building initiatives to maximize their impact.
Microscopic Diagnostics and Mapping of Cytophysiological Effects of Reactive Oxygen Species during Microwave Exposure of Living Tissues
Published on: 30th May, 2025
A specialized installation has been developed for microscopic study of the Reactive Oxygen Species (ROS) formation during microwave irradiation of biological samples with automated control / mechanized tube and real-time data acquisition. The above installation can be used in biomedical practice for: standardization or certification of the microwave sources; testing of the potential antioxidants that protect tissues from ROS-induced effects; testing fluorescent sensors for ROS; analysis of ROS localization and distribution in various tissues in order to establish specific pharmaco-physiotherapeutic and toxicological localizations of ROS in different topographic-anatomical zones. The paper pays special attention to the singlet oxygen produced by the samples upon microwave treatment, as a physiologically active and highly reactive agent.
Pulmonary Pleomorphic Carcinoma: A Rare Entity Revisited!
Published on: 4th June, 2025
Introduction: Pleomorphic Carcinoma (PC) is a subset of poorly differentiated non–small cell lung cancer that is diagnostically challenging because it is a rare malignancy of the lung. It shows varying dual-cell components; spindle or giant cells and epithelial cells.Method: We report a case of 68-year-old non-smoking female who presented with cough, fever, pain in the left side of chest & weight loss of recent onset and an abnormal shadow on her chest X-ray. Computed tomography of chest revealed a well defined heterogeneously enhancing cavitatory soft tissue lesion in the posterior basal segment of the left lower lobe with mediastinal lymphadenopathy.Results: Fine needle aspiration cytology& percutaneous lung biopsy confirmed poorly differentiated malignant tumor. Patient underwent a left lower lobectomy. A diagnosis of PC was confirmed after Immunohistochemistry (IHC). Mutation analysis revealed an EGFR exon 21 mutation within the tumor cells. The patient is on Gefitinib based chemotherapy and has remained disease-free for three years post-surgery.Conclusion: PC of the lung is a rare pathological entity. Definite diagnosis may only be made on a resected tumor along with the use of IHC. Surgical resection is the main modality of the treatment. Such rare cases should be documented to establish an optimal management plan and to provide a further insight to targeted therapy.
The Rarest Case of Acute Bulbar Palsy due to Internal Jugular Vein Thrombosis Secondary to Protein S Deficiency: Vernet Syndrome
Published on: 10th June, 2025
Dural Venous Sinus Thrombosis (DVST) is a rare although serious clinical entity that causes approximately 0.5% of all stroke cases. Head trauma with skull base fracture, aneurysm, CNS infection, thrombophilia, and vasculitis may be identified as a possible cause of DVST. Vernet’s Syndrome is characterized by a constellation of unilateral cranial nerve palsies involving the 9th, 10th, and 11th cranial nerves due to compression or narrowing of the jugular foramen. We herein present a case of 33 years old Bangladeshi worker from Malaysia who had history of severe Traumatic Brain Injury (TBI) following road traffic accident with multiple skull bone fracture and extradural hematoma 3 months back, presented with acute dysphagia, dysphonia, fever and cough for 6 days. Neurologic examination revealed deviation of uvula to the left side and features of consolidation over right upper chest. Magnetic Resonance Venography (MRV) revealed thrombosis involving right transverse sinus, sigmoid sinus extending up to right internal jugular vein. The diagnosis of vernet syndrome with aspiration pneumonia was made. Later thrombophilia screen showed protein S deficiency. He was treated with broad spectrum antibiotics and started anticoagulation with dabigatran. After 6 months of anticoagulation he recovered fully with no residual neurological deficit.
In at the deep end: Psychosocial aspects of developing autonomy in histopathology training
Published on: 10th July, 2018
OCLC Number/Unique Identifier: 7795981289
Medical postgraduate trainees are given increasing levels of responsibility during training in the apprenticeship-model of training [1-3]. Responsibility is said to be a key driver of deep learning and understanding [4-7]. Trainees with greater levels of responsibility for decision making have higher levels of motivation to learn compared with trainees who self-assess as having less autonomy [5]. The Royal College of Pathologists (RCPath) indicate that ‘graded responsibility’ is part of training histopathologists and provided a framework for implementation with increasingly complex specimens suitable for reporting by more senior trainees [8,9].
Analysing Average Glandular Dose: A Comprehensive Study Comparing Digital Breast Tomosynthesis with Full-Field Digital Mammography in Oman
Published on: 31st March, 2025
Background: Full-field Digital Mammography (FFDM) is essential for the early detection of breast cancer. Digital Breast Tomosynthesis (DBT) has improved cancer diagnosis and reduced false positives in mammography . This study evaluated DRLs for FFDM and DBT at various ranges of Compressed Breast Thickness (CBT).Material and methods: We evaluated the parameters like Average Glandular Dose (AGD), kVp, mAs, Entrance Surface Dose (ESD), and CBT in a retrospective analysis of FFDM and DBT. We computed the mean, median, range, and 75th percentile for Craniocaudal (CC) and Mediolateral Oblique (MLO) views at various breast thicknesses.Results: The DRLs were 0.70 mGy to 2.55 mGy for FFDM and 0.94 mGy to 3.67 mGy for DBT for breast thickness in the range from 20 mm to 89 mm.Conclusion: This analysis revealed that DRLs were significantly lower than international benchmarks . Mammography radiation dose optimisation enhances diagnostic accuracy and patient safety.
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