Khalid Al-Rayess*, Matthew Glover and Ameer Khalek
Published on: 11th July, 2025
Cytomegalovirus (CMV) colitis is classically seen in immunocompromised individuals, such as those with HIV, organ transplants, or receiving immunosuppressive therapy. It is exceedingly rare in immunocompetent patients and can pose a diagnostic challenge, especially when it presents as a mass-like lesion mimicking colon cancer. We report a case of a 78-year-old immunocompetent male who presented with hematochezia and was found to have a bleeding cecal mass initially suspicious for adenocarcinoma. Subsequent histopathology revealed CMV colitis. This case emphasizes the importance of considering CMV colitis in the differential diagnosis of colonic masses, even in immunocompetent hosts.
Arger Bundestappen Nanz*, Cruz García Lirios and María del Rosario Molina González
Published on: 21st July, 2025
The pandemic has been observed as a security phenomenon due to the dimensions it entails, although these dimensions have not been confirmed. The objective of this work was to compare the theoretical structure of security with empirical observations. A cross-sectional, correlational, psychometric, and confirmatory study was conducted with a sample of 100 students selected for their affiliation with institutions committed to implementing the SDGs. The results confirm four of the seven dimensions, and the extension of the model is recognized as an area of opportunity to confirm the remaining three dimensions. It is recommended to expand the number of items and the sample size to increase the total percentage of variance and align the empirical model with the theoretical model reported in the literature.
Biofungicides are prepared based on living micro/organisms or on matters prepared from them. They are based on the antagonism of fungal pathogens and their antagonists. Their effect depends on weather conditions (temperature and moisture) in comparison with chemical fungicides which are effective in all conditions but they let the residues in plants, animals, and men. The future of agriculture will be pure food without chemicals.
David Figueroa, Waldo González, José Arteaga* and Diego Godoy
Published on: 5th August, 2025
Introduction: The medial collateral ligament (MCL), a primary stabilizer against valgus forces, often requires surgical intervention in severe injuries, especially when associated with anterior cruciate ligament (ACL) tears. However, MCL repair or reconstruction is typically reserved for patients who continue to experience persistent valgus instability after nonoperative management has failed. The use of synthetic and biological implants is increasingly popular to augment these procedures, providing both biomechanical reinforcement and promoting natural healing. BioBrace, a biocomposite of collagen and bioabsorbable microfilaments, provides structural support and enhances tissue healing. This article explores the surgical treatment of high-grade medial collateral ligament (MCL) injuries of the knee using BioBrace augmentation through a case series.Methods: Cohort of patients who underwent MCL repair surgery with a bioinductive membrane augmentation (BioBrace) between December 2023 and February 2024. This article presents surgical techniques, indications, and clinical outcomes from a case series, highlighting the benefits of BioBrace augmentation in improving stability and functional recovery. Results: A total of 4 patients underwent MCL repair surgery with BioBrace. Results show that patients experienced reduced instability, faster rehabilitation, and favorable outcomes without significant postoperative complications. Conclusion: This method offers a promising alternative for patients with complex knee injuries, especially athletes, by facilitating early rehabilitation and improving joint stability. Further research is recommended to evaluate long-term efficacy and optimize the surgical approach.
The present study was aimed to screen and quantify the phytochemicals by qualitative and quantitative analysis in methanol and aqueous leaf and stem extracts of Marsilea quadrifolia(L.). In qualitative analysis, the phytochemical compounds such as tannins, saponins, flavonoids, steroids, terpenoids, triterpenoids, alkaloids, carbohydrates, proteins, anthroquinones, phenolic compounds and phytosterol were screened. Among these phytocompounds tannins, saponins, flavonoids, steroids, alkaloids, carbohydrates, proteins and phenolic compounds were observed in methanol and aqueous leaf and stem extracts of M. quadrifolia. Anthroquinones were absent in both leaf and stem extracts of M. quadrifolia. The content of phenolic compounds 8.34±0.92 mg/g and 7.31±0.46 mg/g, flavonoids 7.46±0.64 mg/g and 6.45±0.68 mg/g, alkaloids 6.12±0.51 mg/g and 5.89±0.61 mg/g, tannins 6.58±0.72 mg/g and 6.07±0.56 mg/g and saponins 5.32±0.48 mg/g and 6.30±0.58 mg/g were determined in leaf and stem of M. quadrifolia, respectively. So, the present study confirmed that the presence of phytocompounds in leaf and stem of M. quadrifolia.
Endoscopic procedures in patients with comorbidities such as Ischemic Heart Disease (IHD), respiratory compromise, or anticipated difficult airways present considerable anaesthetic challenges. Intubation and positive pressure ventilation, although standard, can be detrimental in such patients due to risks of sympathetic stimulation, barotrauma, or prolonged recovery. Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) is gaining attention as a method to maintain oxygenation without intubation. We share our clinical experience using THRIVE during upper endoscopic procedures to avoid intubation in 10 high-risk patients, demonstrating its feasibility, safety, and clinical benefits.
Rezk R Ayyad, Yasser Abdel Allem Hassan and Ahmed R Ayyad*
Published on: 26th August, 2025
Pharmacovigilance is concerned with the adverse effects of the authorized drugs after use, hence if the adverse effects are harmful and deteriorate other organs or tissues of the patient. These adverse effects were reported by the patients, pharmacists, nurses, clinicians, and physicians. Some examples which withdrawal from the markets according to the pharmacovigilance: astemizole, cisapride, terfenadine, and rofecoxib, which revealed many adverse effects leading to their withdrawal these drugs from the markets.Aim of the research: The knowledge around pharmacovigilance and improving the side effects of drugs which present in the market, the results of this improvement led us to obtain new drugs without serious side effects. We conclude that the market drugs improved from the older drugs, have side effects will are suitable to the usage by patients.
Vegetable production by grafting is a technique which it has made possible to resume agricultural soils which previously could not be produced due to stress generated by various abiotic factors, like a lack of water, stress by high or low temperatures, and or heavy metal contamination, among them. It has been documented and defined a number of graftings which they are tolerant to different factors; however, when it comes to auscultating information related to understand the molecular responses and observe what are the biochemical changes and physiological responses of grafted plants, it is dispersed. The current paper attempts to provide basic information documented on technique, addressing the molecular, biochemical and physiological responses, and thus get a clear perspective on the use of grafts, making this practice be used with most frequently by all its advantages.
Diseases are a major cause of post-harvest losses depending on season, region and management practices. Chemical control is the most used but with serious consequences for human health and the environment. This forces us to carry out more exhaustive studies on botanical products. The general objective of the present study was to evaluate the effect of citrus extracts for the control of pathogens that cause post-harvest diseases in tomato fruit. The product to be evaluated is of botanical origin from citrus extracts. Doses were evaluated (0, 666, 1000, 2000, 4000, 8000 ppm). The treatments were located at a temperature of 25°C±2 and 45% relative humidity (rH). The design used corresponded to a completely random design. The least significant difference was estimated by Tukey Multiple Range test at P=0.05. The statistical tests were performed through the SAS computer program. The results indicate that the pathogens detected and identified correspond to Alternaria tenuissima; Botrytis cinerea; Cladosporium fulvum; Colletotrichum coccodes; Fusarium oxysporum; Geotrichum candidum; Rhizopus stolonifer and Stemphylium macrosporoideum. Our conclusion is that the efficient doses correspond to 666, 2000 and 8000 ppm. With the application of citrus extracts, the damage percentage of tomato fruit was reduced in relation to the control treatments. Based on the results with the application of citrus extracts, the shelf life of the tomato was lengthened.
The armored scale Aulacaspis alisiana, is a serious invasive pest of the Japanese silver tree, Neolitsea sericea, causing serious damage to the tree in Japan. However there are currently no control approaches available for it, complicated by shortage of information on the pest. We studied life history strategies of A. alisiana on N. sericea in Fukuoka Prefecture with a view to providing a basis for formulating sustainable control based on an understanding of the behavior of the pest and potential role of its natural enemies. We established that A. alisiana had three overlapped generations in Fukuoka, with generation times ranging between 65 and 71 days. The adults were relatively fecund, with each female producing between 60 and 67 eggs, with high hatchability, >78%. The pest settled on the lower side of leaves, and although it generally preferred younger leaves, it did not attack newly emerged leaves. Natural enemy groups comprising ants, spiders and beetles (coccinelids) played an important role in regulation of the pest population, with natural mortality of about 30%. They could thus form a critical component of an integrated management approach for the pest in Fukuoka.
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