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In this manuscript, we present an Hiatal hernia(HH) with situs inversus totalis(SIT) performed by transumbilical single-incision laparoscopic hiatal hernia repair and Nissen fundoplication, which is rarely reported previously. A 62-year-old woman was admitted with a diagnosis of hiatal hernia and gastroesophageal reflux disease (GERD), as proven by Gastroesophageal Reflux Disease Questionnaire (GERD-Q) scoring, endoscopic, and radiologic findings. The patient had a history of spinal correction surgery for scoliosis five years ago, during which her SIT was identified. We performed a classic LHHR plus Nissen fundoplication for the patient, especially through a transumbilical single incision. An atraumatic method of liver retraction with a Veress needle sheathed by a latex tube and a convenient autosuturing device was used to overcome the difficulties. The patient experienced an uneventful recovery and presented complete resolution of GERD at the one-month follow-up.

This review gives a brief introduction to the microarray technology and its experimental design and data analysis and a discussion of recent global progress in research using microarray technology in fish biology and aquaculture. DNA microarrays have been reported to have been used for the analysis of gene expression during various physiological, developmental or cellular processes in fish. During the recent past, investigators have begun to use microarrays on fish to address ecological, evolutionary and environmental questions including the variability of gene expression in natural populations, speciation, ecotype diversity, environmental remediation and host-pathogen interactions. The study suggests that a lot of gene expression studies have been conducted on salmon and zebrafish in Europe and USA. The same may be applied on Indian Major Carps and Catfishes to augment productivity from aquaculture sector. 

Cystoid Macular Oedema (CMO) is a condition characterized by fluid accumulation in the macular region of the retina, leading to the formation of cyst-like spaces. This edema often results in visual impairment and is associated with various ocular and systemic conditions, including surgery, inflammation, or medication use. The authors present a case where Cystoid Macular Oedema (CMO) occurred after commencing topical bimatoprost in a pseudophakic patient with primary open angle glaucoma. The macular oedema was treated effectively with a combination of non-steroidal and steroidal topical drops. This case report shows a possible correlation between bimatoprost and CMO, in a patient with no recent confounding risk factors known to contribute to CMO . The recommendation from this report is that all patients treated with topical bimatoprost drops should have a baseline macula OCT examination and a repeated OCT examination 8 weeks after initiation of treatment, to facilitate early detection of CMO.

This editorial explores the crucial yet often overlooked role of sleep in enhancing student-athlete performance and well-being. It highlights sleep’s impact on physical recovery, cognitive function, and emotional stability, emphasizing the unique benefits for athletes. The editorial examines the detrimental effects of early school start times on adolescent sleep patterns and their subsequent impact on academic and athletic performance. By advocating for policy changes that prioritize sleep, such as delaying school start times, this editorial presents a novel approach to optimizing student-athlete success. Through a synthesis of current research and practical insights, it urges stakeholders in education and sports to recognize and act upon the foundational importance of sleep, positioning it as a key component of athletic and academic excellence.

Aim: This study aims to determine the current status for estimation of radiation dose to blood vessels and components from medical imaging procedures.Methodology: A database search on internet via PubMed and Google Scholar was performed to find published papers in estimation of radiation dose to blood vessels and components from medical imaging procedures. Results: Few published papers were found; namely two published papers. Radiation dose to blood vessels and components were assumed to be included in total radiation dose estimation for organ or tissue, without considering different in radiosensitivity. Conclusion: It seems that effect of radiation on blood vessels and components is underestimated, in ICRP 60 and 103 recommendations reports. Recommendation: It is recommended to conduct more studies to estimate radiation dose for blood vessels and components from medical imaging procedures and revise the value of tissue weighting factor for bone marrow.

Bruxism, characterized by involuntary, repetitive jaw-muscle activity including clenching and grinding of teeth, can lead to significant dental and muscular complications. Conventional treatments—such as occlusal splints and behavioral therapy-may not fully address muscular hyperactivity. Botulinum toxin type A (BoNT-A), a neurotoxin that inhibits acetylcholine release at neuromuscular junctions, has emerged as a promising therapeutic option. This article reviews clinical studies regarding the efficacy of BoNT-A injections into masticatory muscles for bruxism management, with a focus on clinical outcomes, safety, and practical considerations.

Telemedicine has become widely used, primarily following or during the COVID pandemic. However, it was used a long time ago in specific cases, like submarines and space. Telemedicine has been developed to facilitate diagnosis and treatment in areas without physicians, either because the area is isolated without a medical doctor (as in submarines and space) or because we need expertise. This article is a review using studies selected via PubMed to collect generic knowledge on some technical details on both sides: Earth and Space, where telemedicine activity is regularly provided. The goal was to compare tools, data collected, and ways of improvement in each area. As experienced on both sides, indeed, the author has already worked in the spaceflight area with astronauts as well as doing teleconsultations with patients nowadays, which allows us to see how we could improve the way we are doing teleconsultation on Earth by teaching the users as done with the astronauts in the pre-flight period. It seems telemedicine will still be mandatory for a while because as seen in many countries even out of the scope of isolated area (or very difficult to be accessed (like mountains, desert …), more and more small cities and even bigger are lacking general practitioner (GP) as well as some specialists. Taking into account the time needed to have a functional doctor (for a GP mainly 8 years and for specialists longer, up to 12 years), telemedicine should improve and take a real place in the health system. This review gives a few definitions, also the term telehealth or e-health is widely used. It refers to the use of an internet communication system to transmit data, receive data, communicate in real time, and guide and provide healthcare services to the patient remotely. Improvements in technologies have mainly been done for Earth applications, and tools are becoming smaller and more resistant. The different purposes of using telemedicine are increasing nowadays, and it is not used only because of a lack of physicians but to teach remotely and avoid travel, as well as to have direct access /advice with a specialist. We can find a lot of reasons to use it. Living in space is a real challenge for the human body used to gravity. As explained in a lot of reviews, the body in space loses bone, muscle, and has changes in heart volume and excitability. All the body systems will suffer from microgravity. Other factors impacting the body in space are the high level of ionized radiation, plus isolation. This is why, since the beginning of space flight, the so-called flight surgeon (more GP of the astronaut than a surgeon) is using telemedicine with the astronauts to prevent disease and, in case a medical event happens, to help the astronaut receive a diagnosis and efficient treatment. The actual ISS, International Space Station, allows real-time communication with the astronauts. This will be used for direct discussion or conferences to check the medical/psychological/fitness status. In other cases, remote access can always be done to communicate pictures or movies to provide advice on health or science. Furthermore, some medical tests will be done to guide the astronauts because some tools need real expertise to be interpreted correctly. In that case, eye exam is a good example: an astronaut uses devices following the recommendation of the specialist based on the NASA Console in Houston. Of course, new improvements are needed to facilitate the next challenges of spaceflight, also going a step further beyond LEO (Low Earth Orbit), like doing an interplanetary trip and going to Mars. In that next scenario, to allow the mission where the Earth will not be seen anymore, when the real-time exchange will not be feasible, a new autonomy of the astronauts will be required. As on Earth, space with all technologies like satellite is not only used as for direct health care facility with the astronauts but also in a more preventive way. It is possible to follow changes on the ground, climate changes too, as a witness to a possible new epidemic, and another specific use is to help in locating people. Finally, we see how the way telemedicine is done in space could help improve telemedicine on the ground. First of all, we could improve telemedicine in many ways on Earth for classical consultation by increasing the utilization of simple tools like otoscope and… more in that case we need to train the patient like the astronauts are trained on ground before flying, this has a huge positive effect in allowing easier diagnostic and then better treatment for example when good pictures are provided. The new tools as Artificial Intelligence (AI) or Virtual Reality (VR), on trial if needed for long-duration missions and specifically for missions beyond low Earth orbit, should be beneficial as well on Earth. Maybe the big challenge for Earth’s Telemedicine is increasing the trust in practitioners who are still convinced that this way of providing medicine could be a competitor, and for that reason, they are reluctant to use it. Nowadays, it should become more and more obvious that we need to work on some specific weak points, like security, training in using tools to make sure telemedicine is efficient and useful, where we have a lack of physicians.

Vildagliptin is an orally active, potent, and selective Dipeptidyl Peptidase-4 (DPP-4) inhibitor, shown to be effective and well tolerated in patients with Type 2 Diabetes Mellitus (T2DM) as either monotherapy or in combination with other anti-diabetic agents. Vildagliptin is used to treat type 2 diabetes mellitus, typically in conjunction with diet and exercise. Vildagliptin is usually administered orally, with a common dosing regimen of 50 mg twice daily. It can be taken with or without food; however, it is important to take it consistently at the same time each day for optimal effectiveness.This study focuses on the most recent advancements in analytical methods for determining the presence of Vildagliptin in different biological media, such as human plasma and urine, as well as in bulk and commercial dose forms. The following analytical techniques will be fully investigated in this paper: High-pressure Liquid Chromatography (HPLC), High Efficiency Thin Layer Chromatography (HPTLC), liquid chromatography coupled to a tandem mass spectrometry system (LC-MS), and electrophoresis. These techniques include several parameters, such as the following: matrix, dynamic phase composition, permanent phase RF value for sensing frequency, retention duration, DL, carrier gas, flow rate, capillary wavelength, separation voltage, temperature, and pressure.

Digital regression models based on an interactive questionnaire and objectively measured results were used for the investigation of new objective methods of remote monitoring of respiratory patients. 43 patients with COPD and 26 with bronchial asthma were examined in a retrospective-prospective observation study before and after exacerbation in the hospital (the first observation). After that, theywere monitored by a digital system with an interactive questionnaire including results of Smart Watch use and a velometric test at home for at least 6 months. The effectiveness of remote patient monitoring was achieved by changes in the treatment program and rehabilitation. An integrative scale for patient monitoring effectiveness evaluation was used for a comparison study before and after remote monitoring wasstarted (historical control). The results of correlation, regression analysis, and OR calculation showed that new monitoring parameters: velometric test distance, daily steps count, night sleep duration, and the number of night awake ups were dependent on the dyspnea score and FEV1. The system of remote patient monitoring based on a digital model decreased the number of calls for emergency medical care, hospitalizations, and increased the effectiveness score of patient monitoring.

Biofungicides are prepared based on living micro/organisms or on matters prepared from them. They are based on the antagonism of fungal pathogens and their antagonists. Their effect depends on weather conditions (temperature and moisture) in comparison with chemical fungicides which are effective in all conditions but they let the residues in plants, animals, and men. The future of agriculture will be pure food without chemicals.